Abstract | OBJECTIVES:
Isoflurane preconditioning has been shown to protect endothelial cells against lipopolysaccharide and cytokine induced injury. This study was designed to determine whether isoflurane preconditioning increased endothelial cell tolerance to ischaemia. METHODS: KEY FINDINGS: CONCLUSIONS: The results suggest that isoflurane preconditioning induces endothelial protection against in-vitro simulated ischemia. This protection may be mediated at least in part by conventional PKCs and mitochondrial K( ATP) channels. The results also indicate that PKCs may be downstream of K( ATP) channels in causing endothelial protection.
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Authors | Jifeng Feng, Zhiyi Zuo |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 63
Issue 1
Pg. 106-10
(Jan 2011)
ISSN: 2042-7158 [Electronic] England |
PMID | 21155822
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 The Authors. JPP © 2010 Royal Pharmaceutical Society of Great Britain. |
Chemical References |
- Anesthetics, Inhalation
- Potassium Channels
- mitochondrial K(ATP) channel
- Isoflurane
- L-Lactate Dehydrogenase
- Protein Kinase C
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Topics |
- Anesthetics, Inhalation
(administration & dosage, pharmacology)
- Animals
- Cattle
- Cells, Cultured
- Dose-Response Relationship, Drug
- Endothelial Cells
(drug effects, pathology)
- Ischemia
(drug therapy, pathology)
- Ischemic Preconditioning
(methods)
- Isoflurane
(administration & dosage, pharmacology)
- L-Lactate Dehydrogenase
(metabolism)
- Potassium Channels
(metabolism)
- Protein Kinase C
(metabolism)
- Pulmonary Artery
(cytology, drug effects, pathology)
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