Fentanyl (Sublimaze)

A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)

Also Known As:

Networked: 4324 relevant articles (451 outcomes, 706 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Mercadante, Sebastiano: 25 articles (02/2016 - 09/2002)
2.	Messina, John: 15 articles (06/2012 - 11/2006)
3.	Mystakidou, Kyriaki: 14 articles (11/2013 - 01/2002)
4.	Xie, Fang: 13 articles (06/2012 - 01/2007)
5.	Casuccio, Alessandra: 12 articles (11/2015 - 08/2005)
6.	Kang, Hyun: 12 articles (04/2015 - 10/2011)
7.	Simonnet, Guy: 12 articles (10/2011 - 02/2002)
8.	Viscusi, Eugene R: 10 articles (01/2016 - 03/2004)
9.	Dahan, Albert: 10 articles (04/2015 - 01/2006)
10.	Suzuki, Tsutomu: 10 articles (01/2014 - 04/2002)

Related Diseases

1.	Pain (Aches) 12/15/2012 - "The pain persisted for more than two weeks and was not relieved by multiple regimens of opioid and nonopioid medications, including extremely high doses of i.v. fentanyl. " 01/01/2015 - "It is concluded, from this population-based data, that the proprietary, transdermal fentanyl matrix patch is effective and safe for chronic pain management in clinical practice, with significant positive analgesic and QoL effects, while being well tolerated and exhibiting good or very good adhesiveness. " 03/01/2011 - "Fentanyl is a potent synthetic opioid used for the management of chronic pain. " 04/07/2005 - "Chronic pain can be effectively treated with fentanyl-TTS, which has a very favorable side effect profile. " 01/01/2004 - "The TTS-fentanyl group also showed significantly greater improvements of important G-BPI domains including global quality of life, pain, and physical, cognitive, and role functioning, than the P/C group (p< 0.01). "
2.	Neoplasms (Cancer) 09/01/2013 - "Sublingual fentanyl ODT provided rapid and consistent relief from BTP, both in cancer and non-cancer patients. " 06/01/2009 - "This prospective study showed the safety and efficacy of direct fentanyl patch introduction in Japanese gastroenterological cancer patients, and the treatment had good feasibility. " 10/01/2009 - "The method described is simple, accurate, and reproducible, and should be helpful for the therapeutic monitoring of fentanyl in cancer patients." 12/15/2001 - "A safe and effective method for converting cancer patients from intravenous to transdermal fentanyl." 03/01/2004 - "These data provide some evidence that the psychological status, as measured with respect to depression and anxiety in patients with advanced cancer, is improved in patients receiving TTS-fentanyl. "
3.	Postoperative Pain 01/01/2010 - "Fentanyl was less effective in subjects with the G allele of the OPRM1 A118G SNP than in those with the A allele, and subjects with the G allele required more fentanyl for adequate postoperative pain control than those with the A allele. " 09/01/2009 - "Fentanyl was less effective in subjects with the G allele of the OPRM1 A118G SNP than those with the A allele, and subjects with the G allele required more fentanyl for adequate postoperative pain control than those with the A allele. " 01/01/2005 - "Clinical studies have shown that the fentanyl HCl PCTS is effective in the management of acute postoperative pain. " 03/01/1999 - "The addition of fentanyl may be effective for both intraoperative and postoperative pain relief. " 11/01/1992 - "Transdermal fentanyl was found to be effective in the control of chronic and postoperative pain. "
4.	Postoperative Nausea and Vomiting (PONV) 05/01/2003 - "This study was designed to estimate the effects of intraoperative intravenous administration of fentanyl on PONV in paediatric daycase surgery. " 04/01/2001 - "A randomised study of the effect on PONV of two anaesthetic techniques: low and high dose i.v. fentanyl and epidural infusions with and without fentanyl." 11/01/2014 - "On the other hand, intraoperative fentanyl use was independently associated with PONV [3.10 (1.25-8.92); P = 0.0138]. " 09/01/2014 - "Analysis of the results showed that the frequency of postoperative nausea and vomiting after anaesthesia without fentanyl by 14% lower than with fentanyl. " 09/01/2014 - "Laparoscopic surgery and higher dose of fentanyl were not risk factors for PONV. "
5.	Nausea 09/01/1999 - "One subject discontinued participation before fentanyl administration because of severe side effects, and during the study 8 of the remaining 11 subjects reported nausea. " 11/01/2014 - "However, there were no irreversible or severe adverse events in both treatment groups and nausea was the most common (14/103, 13.6%) complaint reported in the fentanyl group. " 06/01/2014 - "Nausea was significantly more common in the fentanyl group compared with both other groups. " 09/01/2008 - "In the fentanyl group, one patient had slight nausea but needed no care. " 09/01/2001 - "Nausea was observed in 1 patient in each fentanyl group. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Opioid Analgesics (Opioids)
3.	Propofol (Diprivan)
4.	Bupivacaine (Bupivacaine Hydrochloride)
5.	Lidocaine (Xylocaine)
6.	Ketamine
7.	Fentanyl (Sublimaze)
8.	Midazolam (Versed)
9.	Buprenorphine (Subutex)
10.	Ondansetron (Zofran)

Related Therapies and Procedures

1.	Analgesia
2.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
3.	Anesthesia
4.	Transdermal Patch
5.	General Anesthesia