Hypervitaminosis A

02/01/1979 - "Clearance of retinol from plasma increased 2-fold with hypervitaminosis A, exhibited a greater response in the mild group, and increased linearly with vitamin A concentration in plasma. "
12/01/1992 - "This study provides evidence that long-term supplemental vitamin A in doses commonly found in multivitamin supplements does not present a risk for hypervitaminosis A."
05/01/2015 - "Vitamin A plays an essential role in animal biology and has negative effects associated with both hypo- and hypervitaminosis A. "
01/01/2010 - "The effects of hypervitaminosis A in sheep following intramuscular administrations of vitamin A."
06/01/2006 - "Further work is necessary to determine whether the hypervitaminosis A in children reflects an excessive dietary intake of retinol. "

01/01/1977 - "Histochemical studies on respiratory enzymes in hypervitaminosis A."
01/01/1971 - "Urinary excretion of lysosomal enzymes in hypovitaminosis and hypervitaminosis A in children."
08/15/1978 - "Activity of phospholipases A and some lysosomal enzymes in rat testes at different stages of hypervitaminosis A."
05/01/1960 - "On the basis of these observations, it is suggested that the changes in cartilage seen in experimental hypervitaminosis A may be the result of activation of a proteolytic enzyme or enzymes with properties similar to papain."
12/01/1978 - "It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A."

07/01/2004 - "In conclusion, vitamin E therapy appears to be an effective treatment for hypervitaminosis A."
07/01/1970 - "Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity."
10/01/1991 - "These results extend to adult rats previous findings that excess retinyl palmitate alters vitamin E and carotenoid status prior to the manifestation of clinical signs of hypervitaminosis A. "

12/01/1978 - "It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A."
05/01/2007 - "In addition to the wide variety of hypercalcemia and/or hyperphosphatemia-causing clinical conditions, GMC has also been associated with atrophic gastritis, hypervitaminosis A, organ transplantation, gastric neoplasia, uremia with eucalcemia/euphosphatemia, and the use of aluminum-containing antacids, citrate-containing blood products, isotretinoin, and sucralfate. "

12/01/1978 - "It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A."
12/01/1978 - "Furthermore, hypervitaminosis A decreased the activities of two key hepatic glycolytic enzymes, phosphofructokinase, and pyruvate kinase, without affecting those of hexokinase and glucokinase. "

11/01/1983 - "This therapeutic activity in combination with the determination of a therapeutic index (relation between therapeutic action and hypervitaminosis A syndrome) served as criteria in choosing retinoids for clinical trials in dermatologic and oncologic diseases. "
05/01/2004 - "Two major problems in the clinical use of retinoids are that the doses needed for successful treatment are often toxic, leading to "hypervitaminosis A syndrome" and that patients often develop drug resistance. "
03/01/1995 - "Side effects of retinoids are those of the hypervitaminosis A syndrome and have to be considered in every patient treated with this drug. "
05/01/1990 - "This review will focus on the clinical and pathologic findings of hepatic involvement in chronic hypervitaminosis A and on the evidence concerning the potential hepatotoxicity of currently available synthetic retinoids."
01/01/1990 - "The combination of the results of mouse antipapilloma tests with those from hypervitaminosis A tests in mice as the basis for calculating a therapeutic index has been used for more than 20 years in the search for retinoids as useful drugs in human dermatology. "

01/01/1985 - "This study hypothesizes the possible implication of vitamin intoxication, namely, hypervitaminosis A, in the etiology of some cases of pibloktoq. "
03/01/2003 - "These calves had been administered excessive amounts of vitamins A, D3 and E, and blood chemistry of acute case showed hypervitaminosis A and E. "
09/01/1992 - "Hypervitaminosis A in a one-year-old child resulted from overfeeding of daily vitamin supplements by a caretaker. "
05/21/1985 - "In addition to producing the skin and systemic effects of hypervitaminosis A, these metabolites presumably enter the fetal circulation, leading to pregnancy abnormalities similar to those associated with high doses of the vitamin for the treatment of skin disorders."
01/01/1984 - "In class A) the congenital syndromes are still not well known, the acquired syndromes comprise those with hypervitaminosis (hypervitaminosis A and D) and those without hypervitaminosis (for the other vitamins). "

08/01/1993 - "Numerous studies of experimental hypo- and hypervitaminosis A have long suggested that retinoic acid (RA) is involved in chondrocyte maturation during endochondral ossification and skeletogenesis. "
02/01/1996 - "Ultrastructural and biochemical investigations indicated epidermal hypervitaminosis A, probably related to alteration of epidermal retinoic acid metabolism. "
05/01/1992 - "administration in mice and produced no signs of hypervitaminosis A-related toxicity at twenty times the no effect dose of tretinoin. "
09/01/1989 - "Tretinoin cream has an excellent safety record; a local cutaneous hypervitaminosis A reaction is the only common problem."
09/15/1978 - "However, treatment with retinoic acid is limited by serious side effects (hypervitaminosis A syndrome). "

12/01/2014 - "β-Carotene from maize was efficacious when consumed as a staple food in this population and could avoid the potential for hypervitaminosis A that was observed with the use of preformed VA from supplementation and fortification. "
10/01/2015 - "Former studies suggested an adverse effect of hypervitaminosis A on bone health, while the effects of retinol and its precursor (β-carotene) remain uncertain in populations consuming vitamin A (VA) mainly from plant sources. "
08/01/2015 - "The finding of hypervitaminosis A in Zambian children was supported by high circulating concentrations of carotenoids and mildly elevated serum retinyl esters. "
02/01/1976 - "Biochemical investigations have shown that the administration of vitamin A acid is associated with elevation of serum levels of retinol and carotene and after high dosage symptoms develop identical with hypervitaminosis A. "

06/01/1996 - "Endocrine disorders such as obesity and hypoparathyroidism, hypervitaminosis A, tetracycline use and thyroid replacement are probable causes of benign intracranial hypertension. "
09/01/2003 - "Pseudotumor Cerebri (PTC) is an uncommon disorder whose etiology is largely unknown, although its association with steroid withdrawal, hypervitaminosis A, and the use of the tetracycline group of drugs has been well documented. "
10/01/1986 - "A collaborative study was conducted to investigate the teratological susceptibility of the Pika (Ochotona rufescens rufescens) to selected teratogenic chemicals: cyclophosphamide, 6-mercaptopurine, 5-fluorouracil, 6-aminonicotinamide, actinomycin D, ethylurethan, ampicillin, tetracycline, thalidomide, diphenylhydantoin, hypervitaminosis A, aspirin, dexamethasone, betamethasone and bredinin. "

03/01/2006 - "An 8.5-year-old girl with classical maple syrup urine disease (MSUD) required liver transplantation for hypervitaminosis A and was effectively cured of MSUD over an 8-year clinical follow-up period. "
03/01/1990 - "The study included liver diseases (such as alcoholic liver diseases, benign and malignant liver tumors, cholestasis of various origins, fulminant hepatitis, acute rejection after orthotopic liver transplantation, Budd-Chiari syndrome), as well as general or extrahepatic diseases (such as diabetes, hemochromatosis, hypervitaminosis A, various hematological disorders), and normal controls. "

02/01/1995 - "Hypervitaminosis A in two hemodialysis patients."
01/01/1984 - "Hypervitaminosis A toxicity in regular hemodialysis patients."
02/01/1995 - "We will discuss the reason why hemodialysis patients are at special risk for the development of hypervitaminosis A and review the mechanism leading to the associated hypercalcemia."
08/01/1983 - "Hypervitaminosis A, hypercalcemia and hemodialysis."
07/01/1979 - "Hypervitaminosis A in a patient with alopecia receiving renal dialysis."

09/01/1992 - "Most cases of chronic hypervitaminosis A are the result of self-medication or health food faddism. "
01/01/1975 - "Evaluation of the 132 cases of chronic hypervitaminosis-A showed that approximately one quarter cannot be considered as genuine cases, whereas the rest is divided almost equally between vitamin A prescription and self-medication. "
01/01/1975 - "Whereas acute vitamin A intoxication has lost numerical importance during the past 15 years, chronic hypervitaminosis-A, especially that caused by self-medication, has provoked world-wide discussion concerning the safety of retinol intake. "

02/01/1981 - "Development of hypervitaminosis A in a patient on long-term parenteral hyperalimentation."
07/01/1986 - "We present three patients with renal failure receiving total parenteral nutrition (TPN) who developed biochemical and clinical findings of hypervitaminosis A. "
02/01/1981 - "A four and one-half year old boy with intestinal pseudo-obstruction who had been maintained on parenteral hyperalimentation for one year developed classical signs of hypervitaminosis A. "

12/01/2008 - "The authors observed hypervitaminosis A in pediatric hematopoietic stem cell transplant (HSCT) patients. "