Retinoids

A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.

Networked: 2618 relevant articles (246 outcomes, 374 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Feldman, Steven R: 14 articles (11/2015 - 09/2003)
2.	Gronemeyer, Hinrich: 13 articles (08/2015 - 05/2002)
3.	Lotan, Reuben: 13 articles (06/2010 - 01/2002)
4.	Christov, Konstantin: 10 articles (07/2015 - 10/2004)
5.	Soprano, Kenneth J: 10 articles (11/2007 - 03/2002)
6.	Soprano, Dianne Robert: 10 articles (11/2007 - 03/2002)
7.	Gudas, Lorraine J: 9 articles (02/2011 - 02/2002)
8.	Terao, Mineko: 8 articles (07/2014 - 11/2002)
9.	Garattini, Enrico: 8 articles (07/2014 - 11/2002)
10.	Shudo, Koichi: 8 articles (10/2012 - 01/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1996 - "Most of the results from experimental animal studies indicate that retinoids are effective in preventing or suppressing cancers. " 10/01/1986 - "If they prove safe and effective, the use of topical retinoids in the prevention and treatment of cutaneous tumors may be the most significant clinical application of these drugs." 04/01/2001 - "Retinoids are important modulators of epithelial differentiation and proliferation and are effective in the treatment and prevention of several epithelial cancers. " 10/21/1999 - "All three retinoids caused a statistically significant reduction in tumor size as determined by the Student t-test (P < 0. " 04/01/1997 - "On the basis of the considerably long, although incomplete, remission with good drug tolerance in spite of the high doses used as well as the undoubtedly major antineoplastic strength of the latest generation of synthetic retinoids, we feel that these findings could be a good starting point for further experimental verifications of the therapy of this aggressive cutaneous neoplasm."
2.	Acne Vulgaris 09/01/2008 - "Topical retinoids are highly effective in the treatment of both comedonal and inflammatory lesions of acne and are a vital part of almost any acne regimen. " 01/01/2008 - "The broad anti-acne activity and safety profile of topical retinoids justifies their use as first-line treatment in most types of non-inflammatory and inflammatory acne. " 02/01/2005 - "Despite published data showing the efficacy of topical retinoids in treating inflammatory acne, in clinical practice topical retinoids tend to be used most commonly for noninflammatory acne. " 08/01/2005 - "ALA-IPL are beneficial in the management of acne vulgaris and may be used in combination with other forms of acne treatment or may be an alternative treatment for patients who do not want to take systemic retinoids." 01/01/2003 - "When added to antibacterial therapy, topical retinoids demonstrate faster and significantly greater reduction of inflammatory acne lesions and comedones than antibacterials alone."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 10/01/2000 - "The present study, however, reconfirmed the high efficacy of systemic retinoids in pustular- and erythrodermic psoriasis. " 03/01/1979 - "Oral application of newly synthesized retinoids, however, was beneficial in psoriasis, particularly in erythrodermic or pustular types. " 01/01/1983 - "Oral retinoids produced more than 75% improvement in all eight patients with pustular psoriasis. " 01/01/1983 - "Oral retinoids gave more than 70% improvement in six of the seven patients with recalcitrant psoriasis. " 01/01/2005 - "Studies have shown that retinoids are particularly effective in the treatment of pustular and palmoplantar psoriasis. "
4.	Carcinoma (Carcinomatosis) 06/01/2010 - "Additional preventive measures include identifying high-risk individuals for early detection along with using agents, such as retinoids, that are effective in decreasing the risk of premalignant cells further developing into carcinomas. " 12/01/1998 - "Because preclinical and clinical data on IFN-beta in combination with retinoids show promising results against breast carcinoma, we analysed the anti-proliferative effect of human recombinant IFN-beta alone or in combination with all-trans RA on two human squamous cervical carcinoma cell (SCC) lines (ME180 and SiHa). " 07/01/1994 - "Less data is available on the efficacy of IFNs in the treatment of HPV-related dysplasia and carcinoma, but combination therapy (e.g., IFN-alpha plus retinoids for cervical carcinoma) appears promising. " 07/01/2014 - "CRBP-1 loss in G2/G3 ovarian carcinomas and increased apoptotic susceptibility to retinoids in CRBP-1-transfected-A2780 cells suggest CRBP-1 screening as a target to ensure efficacy of an adjuvant retinoid therapy." 01/01/2010 - "This data indicates that p27(Kip1) deficiency promotes prostate cell proliferation and carcinogenesis but does not affect 9cRA's potential to suppress prostate carcinogenesis, suggesting that patients with PIN and carcinomas lacking or having a low level of p27(Kip1) expression may also benefit from clinical trials with retinoids."
5.	Skin Diseases 07/01/1988 - "Retinoids are potent therapuetic agents that have been found to be effective in a variety of skin diseases. " 07/01/1992 - "Pharmacokinetics and therapeutic efficacy of retinoids in skin diseases." 01/01/1991 - "Systemic retinoids are effective in a variety of inflammatory dermatoses. " 10/01/1997 - "To study the potential efficacy of retinoids on granulocytes with regard to their role in inflammatory dermatoses. " 01/01/1993 - "Systemic retinoids are used in the management of chronic cutaneous conditions and life-threatening dermatoses. "

Related Drugs and Biologics

1.	Vitamin A (Retinol)
2.	Tretinoin (Retinoic Acid)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Isotretinoin (Accutane)
5.	tazarotene (Tazorac)
6.	Cyclosporine (Ciclosporin)
7.	Interferons
8.	Acitretin
9.	Vitamin D
10.	Salicylic Acid (2 Hydroxybenzoic Acid)

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Phototherapy (Light Therapy)
4.	Transplants (Transplant)
5.	Photochemotherapy (Photodynamic Therapy)