Hycanthone

09/01/1978 - "haematobium infections before and 6 weeks after successful treatment with hycanthone; 52 local individuals were studied as controls. "
09/01/1977 - "Genetically transferred resistance to the antischistosomal drug hycanthone has been observed in several strains of Schistosoma mansoni: 1) in the progeny of worms to whose hosts hycanthone had been administered 54 to 70 days after exposure to cercariae (Type I); 2) in the progeny of worms to whose hosts hycanthone had been administered when the worms were still in an immature stage (27 to 29 days after percutaneous cercarial exposure) (Type II); and 3) in the progeny of worms from hosts that had been infected with cercariae of one sex followed by infection with the opposite sex 2 to 58 weeks later (Type III). "
03/01/1977 - "This finding suggests that differences in the reversibility of hycanthone may correlate with the usefulness of the drug in the therapy of schistosome infections by different species of parasites. "
01/01/1974 - "[Effect of hycanthone at different evolutive stages of experimental infection of the mouse by Schistosoma mansoni]."
11/01/1970 - "Etrenol (hycanthone) in the treatment of Schistosoma haematobium infections in Iraq."

01/01/1976 - "Hycanthone in experimental schistosomiasis studies on liver pathology in mice treated with one and two doses."
09/01/1972 - "Preliminary trial of the effect of hycanthone (Etrenol) in the mass treatment of urinary bilharziasis."
10/31/1970 - "Clinical trials of hycanthone (etrenol) in urinary tract bilharziasis."
07/01/1970 - "Clinical trials of Hycanthone in the treatment of bilharziasis."
01/01/1969 - "Field trial of hycanthone (Etrenol Winthrop) in the treatment of urinary and intestinal bilharziasis."

06/01/1977 - "A controlled trial of hycanthone and placebo in schistosomiasis mansoni in St. Lucia."
01/01/1974 - "Clinical trials of hycanthone in schistosomiasis mansoni in St. Lucia."
07/01/1976 - "Hycanthone dose-response in treatment of schistosomiasis mansoni in St. Lucia."
07/01/1975 - "Acute and early chronic phases of schistosomiasis mansoni in children treated with hycanthone."
11/01/1974 - "[Hepatopathy induced following the treatment of schistosomiasis mansoni with hycanthone. "

08/01/1985 - "All persons with 300 or more eggs g-1 faeces were then treated with a single dose of hycanthone, 1.5 mg kg-1 body-weight. "
01/01/1982 - "Hycanthone at a dose of 2.5 mg kg body weight was given in 1973 and 1974 to persons found by a sedimentation concentration technique to be excreting Schistosoma mansoni eggs. "
09/01/1977 - "Most of these, 677, were given a single injection of hycanthone (2.5 mg/kg of body weight), and the same treatment was administered to 159 patients the second year. "
07/01/1978 - "Hycanthone was given as a single intramuscular injection at a dose of 3.0 mg per kilogramme body weight. "
07/01/1976 - "Clinical trials of hycanthone (single intramuscular dose) were undertaken in schistosomiasis mansoni patients in St. Lucia at five dose levels: 3.0, 2.5, 2.0, 1.5, and 1.0 mg/kg body weight. "

05/01/1991 - "Our results in vitro and in vivo indicate that hycanthone and chlorophenoxamine might be appropriate tools for the circumvention of MDR in human tumors."
05/01/1991 - "Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo."
08/01/1980 - "Hycanthone is an antischistosomal drug with promising antitumor activity against experimental animal tumors. "
11/01/1979 - "Hycanthone, an antischistosomal drug possessing activity against experimental murine tumors, was administered by 20-minute infusion daily x 5 days to 12 patients with advanced cancer to determine dose-limiting toxicity and to look for therapeutic effect. "
08/01/1978 - "Hycanthone was given to 15 patients with metastatic cancer in order to determine the maximum tolerable dose. "