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Evaluation of chemotherapy in the control of Schistosoma mansoni in Marquis Valley, Saint Lucia. I. Results in humans.

Abstract
Hycanthone at a dose of 2.5 mg kg body weight was given in 1973 and 1974 to persons found by a sedimentation concentration technique to be excreting Schistosoma mansoni eggs. In a further two campaigns oxamniquine was used (15 mg/kg body weight). The last treatment was given after the 1976 survey and stools of children were re-examined annually but not further treatment was planned. In six villages prevalence remained low, at 4%, 4 years later, in two it increased to 10%, and in two others after 3 years it was 23% and further treatment was offered. Factors affecting renewed transmission and the rate prevalence builds up were investigated and found to be low attendance rate for treatment, greater use of the river water and, possibly, infected immigrants. But if prevalence builds up slowly, retreatment may be necessary only every 3-4 years at an estimated annual cost of 40 cents per person protected.
AuthorsP Jordan, R K Bartholomew, E Grist, E Auguste
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 31 Issue 1 Pg. 103-10 (Jan 1982) ISSN: 0002-9637 [Print] United States
PMID7058971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Nitroquinolines
  • Oxamniquine
Topics
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Emigration and Immigration
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Nitroquinolines (therapeutic use)
  • Oxamniquine (therapeutic use)
  • Recurrence
  • Sanitation
  • Schistosoma mansoni
  • Schistosomiasis (drug therapy, epidemiology, transmission)
  • Water Supply
  • West Indies

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