Experimentally produced resistance of Schistosoma mansoni to hycanthone.

Abstract

Genetically transferred resistance to the antischistosomal drug hycanthone has been observed in several strains of Schistosoma mansoni: 1) in the progeny of worms to whose hosts hycanthone had been administered 54 to 70 days after exposure to cercariae (Type I); 2) in the progeny of worms to whose hosts hycanthone had been administered when the worms were still in an immature stage (27 to 29 days after percutaneous cercarial exposure) (Type II); and 3) in the progeny of worms from hosts that had been infected with cercariae of one sex followed by infection with the opposite sex 2 to 58 weeks later (Type III). In types I and II, drug resistance was transferred maternally. Hycanthone-resistant schistosomes were cross-resistant to antischistosomal drugs structurally related to hycanthone, such as oxamniquine and two chloro-indazole analogs of hycanthone, but not to niridazole and to another nitroheterocyclic compound.

• Authors: W B Jansma, S H Rogers, C L Liu, E Bueding
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 26 Issue 5 Pt 1 Pg. 926-36 (Sep 1977) ISSN: 0002-9637 [Print] United States
• PMID: 907054 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Thioxanthenes
• Oxamniquine
• Hycanthone
• Ethidium
• Quinacrine
• Niridazole

Topics

• Animals
• Drug Resistance
• Ethidium (pharmacology)
• Female
• Genes
• Hybridization, Genetic
• Hycanthone (analogs & derivatives, pharmacology)
• Male
• Mice
• Niridazole (pharmacology)
• Oxamniquine (pharmacology)
• Quinacrine (pharmacology)
• Schistosoma mansoni (drug effects, growth & development)
• Thioxanthenes (pharmacology)
• Time Factors