Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan.

Abstract

The results of a clinical trial of hycanthone in 601 selected Sudanese patients with S. mansoni and S. haematobium infections are reported. Hycanthone was given as a single intramuscular injection at a dose of 3.0 mg per kilogramme body weight. The commonest side effects were nausea and vomiting which occurred in 35 per cent and 32 per cent respectively. No incidence of acute hepatic damage and no deaths were encountered. About one third of patients reported for follow-up. Cure rate for S. mansoni was 90 per cent at 6 weeks of treatment and 97 per cent at three months and six months, while for S. haematobium infection it was 82 per cent at 6 weeks and 91 per cent at 3 months and 6 months. A significant reduction in egg excretion was achieved in those who were not cured.

• Authors: S Y Salih, H Abu Sabaa, D Mustafa
• Journal: The Journal of tropical medicine and hygiene (J Trop Med Hyg) Vol. 81 Issue 7 Pg. 126-30 (Jul 1978) ISSN: 0022-5304 [Print] England
• PMID: 702619 (Publication Type: Journal Article)

Chemical References

• Thioxanthenes
• Hycanthone

Topics

• Adolescent
• Adult
• Aged
• Child
• Female
• Humans
• Hycanthone (adverse effects, therapeutic use)
• Male
• Middle Aged
• Schistosoma haematobium
• Schistosoma mansoni
• Schistosomiasis (drug therapy)
• Sudan
• Thioxanthenes (therapeutic use)