Abstract |
Control of Schistosoma mansoni transmission solely by treatment of all infected persons was attempted in Marquis Valley (population about 3,100), St. Lucia. Two-year results are reported. Excluding 26 pregnant patients, 709 to 729 persons who were found to be infected received treatment the first year. Most of these, 677, were given a single injection of hycanthone (2.5 mg/kg of body weight), and the same treatment was administered to 159 patients the second year. Side effects were not severe; the major side effect, vomiting, occurred in about 22% on both occasions. In villages with initially high transmission rates, the incidence of new infections in children 0 to 14 years fell from 20.8% before chemotherapy to 7.4% after 1 year and to 3.7% after 2 years. This pattern was significantly different from that in the comparison area where no control scheme exists. Chemotherapy alone appears to be a rapid, effective, and comparatively inexpensive method of controlling S. mansoni transmission in St. Lucia.
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Authors | J A Cook, P Jordan, R K Bartholomew |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 26
Issue 5 Pt 1
Pg. 887-93
(Sep 1977)
ISSN: 0002-9637 [Print] United States |
PMID | 907051
(Publication Type: Journal Article)
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Chemical References |
- Nitroquinolines
- Thioxanthenes
- Oxamniquine
- Hycanthone
- Niridazole
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Costs and Cost Analysis
- Female
- Humans
- Hycanthone
(therapeutic use)
- Infant
- Male
- Niridazole
(therapeutic use)
- Nitroquinolines
(therapeutic use)
- Oxamniquine
(therapeutic use)
- Schistosoma mansoni
- Schistosomiasis
(drug therapy, epidemiology, prevention & control)
- Thioxanthenes
(therapeutic use)
- West Indies
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