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Praziquantel (Biltricide)

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An anthelmintic used in most schistosome and many cestode infestations.

Also Known As:

Biltricide; Droncit; Bayer Brand of Praziquantel; Cesol; Cisticid; Cysticide; Drontsit; EMBAY 8440; Merck Brand of Praziquantel; Prasiquantel; Praziquantel, (+-)-Isomer; Praziquantel, (R)-Isomer; Praziquantel, (S)-Isomer; Pyquiton; Traziquantel; 8440, EMBAY; 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-

Networked: 1919 relevant articles (312 outcomes, 236 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Isoquinolines: 16
    - Praziquantel: 1919

Experts

1.	Utzinger, Jürg: 31 articles (10/2015 - 06/2002)
2.	Keiser, Jennifer: 29 articles (01/2016 - 12/2005)
3.	Fenwick, Alan: 17 articles (01/2016 - 01/2006)
4.	Kabatereine, Narcis B: 17 articles (01/2016 - 04/2004)
5.	Stothard, J Russell: 17 articles (07/2015 - 08/2006)
6.	Dunne, David W: 15 articles (01/2016 - 04/2004)
7.	McManus, Donald P: 12 articles (02/2015 - 06/2004)
8.	Vounatsou, Penelope: 11 articles (08/2015 - 06/2002)
9.	Xiao, Shu-Hua: 11 articles (08/2014 - 11/2005)
10.	Wang, Wei: 11 articles (05/2014 - 11/2010)

Related Diseases

1.	Infection 11/01/2013 - "This phenomenon could be explained by extremely rapid re-infection dynamics or a sub-optimal efficacy of praziquantel against S. " 10/01/2009 - "Praziquantel is effective for most intestinal fluke infections. " 10/01/1990 - "Praziquantel, administered over a 72 h period in the food of mature Biomphalaria glabrata harbouring 7-week-old Schistosoma mansoni infections, dramatically reduced the numbers of cercariae shed. " 06/30/2010 - "Although praziquantel exhibits excellent therapeutic efficacy, it shows no preventive action to the infection. " 04/01/1991 - "In late infection 150 mg/kg of praziquantel gave moderate improvement in spermatogenic activity compared to almost complete cure and return to full activity with 300 mg/kg praziquantel regimens. "
2.	Schistosomiasis (Bilharziasis) 07/01/2010 - "The efficacy of oral praziquantel in the treatment of schistosomiasis has been considered low by most public health institutions. " 01/01/2010 - "The advent of the safe, highly efficacious broad-spectrum antischistosomal drug praziquantel, in the mid-1970s, eventually resulted in a change of the global schistosomiasis control strategy from a multi-pronged transmission control approach to drug-based morbidity control. " 01/01/1998 - "These features explain how a very poor autonomous region such as Guangxi finally eradicated schistosomiasis, spending less than US$ 0.50 per protected citizen per year; it is remarkable that the disease and snails were initially found across a large area of complex environments and modern drugs such as praziquantel were not available for most of the 40-year period. " 03/01/2008 - "Praziquantel is still very effective for the treatment of schistosomiasis, but there are rising concerns on the potential risk of developing resistances because of the extensive use of this drug. " 10/05/2001 - "The current drug of choice against schistosomiasis is praziquantel (PZQ), which has minimal side effects and is potent against all schistosome species. "
3.	Body Weight (Weight, Body) 01/01/1984 - "In our clinical trials, complete cure was obtained in 10 patients given praziquantel at a dosage of 3 X 25 mg/kg body weight for 3 consecutive days and with a dosage of 3 X 25 mg/kg for 2 consecutive days, 18 (85.7%) of 21 patients were cured. " 08/01/2013 - "The results show that praziquantel treatments applied early in the grazing season and in monthly intervals were more beneficial for body weight developments in lambs than applied at six-weekly or eight-weekly intervals." 06/01/1984 - "A high percentage of reduction was noted in the mean egg count of the non-cured cases which reached 92.6% in the high-egg-count group who received 40 mg/kg body weight of praziquantel. " 05/01/1991 - "Praziquantel, 40 mg/kg body weight, in a single dose was effective in 89.7% of cases of S. " 01/01/2016 - "Praziquantel, given once at 15 mg/kg body weight (bw), was administered and a dramatic improvement in the clinical condition and biochemical parameters was observed up to 30 days following treatment. "
4.	Neurocysticercosis 01/01/1988 - "A prospective open therapeutic study on volunteers with active neurocysticercosis using pyrazinoisoquinolone (Praziquantel) has shown that it is a safe and effective drug. " 07/01/1999 - "Fifteen-day praziquantel therapy for parenchymal neurocysticercosis has been shown to be effective. " 06/01/1997 - "A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. " 01/01/1990 - "Standard therapeutic regimens of praziquantel for neurocysticercosis use daily doses of 50 mg/kg for 15-21 days, with prolonged remission being achieved in 60-80% patients. " 04/01/1989 - "[Remission of a case of intraparenchymal neurocysticercosis following treatment with praziquantel]."
5.	Cysticercosis 06/01/1984 - "Computer tomography is a valuable adjunct to the diagnosis and follow up of cerebral cysticercosis and praziquantel was found to be very effective in the treatment of the parasitoses." 01/01/1991 - "We experienced a case of pulmonary cysticercosis confirmed at Gyeongsang National University Hospital by means of an open lung biopsy and treated successfully with praziquantel (50 mg/kg per day for 15 days). " 11/01/2000 - "This single-dose regimen of praziquantel seems to be effective for therapy of subarachnoid cysticercosis. " 08/01/1991 - "In order to evaluate therapeutic efficacy of praziquantel against cysticercosis in pigs caused by the 'Taiwan Taenia' 16 small-ear miniature pigs were each fed with 10,000 or 30,000 eggs. " 01/01/1989 - "Clinical evaluation of the therapeutic efficacy of praziquantel against human cysticercosis."

Related Drugs and Biologics

1.	Albendazole (Albenza)
2.	Praziquantel (Biltricide)
3.	emodepside
4.	Oxamniquine
5.	Mebendazole (Vermin)
6.	Antigens
7.	Tablets
8.	febantel
9.	Methoprene
10.	4''-epiacetylamino-4''-deoxyavermectin B1 (eprinomectin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Injections
4.	Investigational Therapies (Experimental Therapy)
5.	Oral Administration