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Hemin (Panhematin)

Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.

Also Known As:

Panhematin; Hematin; Alkaline Hematin D-575; Chlorohemin; Ferrihaem; Ferriheme Chloride; Ferriprotoporphyrin IX; Ferriprotoporphyrin IX Chloride; Protohemin; Protohemin IX; Alkaline Hematin D 575; Chloride, Ferriheme; Chloride, Ferriprotoporphyrin IX; Hematin D-575, Alkaline; Ferriprotoporphyrin; Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-5-13)-

Networked: 689 relevant articles (52 outcomes, 73 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ndisang, Joseph Fomusi: 18 articles (01/2015 - 06/2008)
2.	Jadhav, Ashok: 15 articles (01/2014 - 06/2008)
3.	Liu, Zai-Qun: 8 articles (07/2011 - 02/2008)
4.	Regan, Raymond F: 7 articles (10/2014 - 07/2003)
5.	Desnick, Robert J: 5 articles (01/2015 - 03/2005)
6.	Egan, Timothy J: 4 articles (04/2015 - 05/2006)
7.	Balwani, Manisha: 4 articles (01/2015 - 08/2011)
8.	Tiwari, Shuchita: 4 articles (01/2015 - 01/2013)
9.	Bishop, Glenda M: 4 articles (04/2014 - 01/2009)
10.	Robinson, Stephen R: 4 articles (04/2014 - 01/2009)

Related Diseases

1.	Acute Intermittent Porphyria (Porphyria, Acute) 01/01/2011 - "The patient had a family history of acute intermittent porphyria (AIP) so we decided to begin treatment with hematin, achieving a complete remission of the symptoms. " 10/01/1988 - "Although hematin is frequently effective in the treatment of acute porphyria crises, it is often associated with abnormalities in coagulation and these effects also occur in normal volunteers." 02/01/1983 - "Hematin is clinically useful in the treatment of acute intermittent porphyria. " 12/01/1981 - "Hematin has been shown to be effective therapy for acute intermittent porphyria. " 02/01/1988 - "The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. "
2.	Hemolysis 11/01/2014 - "Moreover, since RBC components, especially those with long-term storage, contained sufficient hemin concentration to induce NETs, special attention to hemolysis of stored RBC components is important." 11/01/2013 - "Infusion of a low dose of hemin caused acute intravascular hemolysis and autoamplification of extracellular hemin in transgenic sickle mice, but not in sickle-trait littermates. " 11/01/2013 - "We tested the hypothesis that the hemolysis byproduct hemin elicits events that induce ACS. " 12/01/2009 - "CAP can also protect erythrocytes against hemin-induced hemolysis." 10/01/2009 - "AM1 or AP4b is not hemolytic per se and is less hemolytic than CQ when hemolysis is accelerated (induced) by hematin. "
3.	Insulin Resistance 01/01/2014 - "The present study examined whether hemin could prevent the development of high-fat diet-induced insulin resistance in the liver and skeletal muscle using a hyperinsulinemic-euglycemic clamp. " 01/01/2014 - "These results suggest that hemin prevents the development of high-fat diet-induced insulin resistance by increased insulin sensitivity in the skeletal muscle. " 01/01/2013 - "Contrarily, the HO-inhibitor, stannous mesoporphyrin nullified the hemin effect, exacerbating inflammatory/oxidative insults and aggravated insulin resistance (HOMA-index). " 06/01/2009 - "Correspondingly, ip glucose tolerance, insulin tolerance, and homeostasis model assessment insulin resistance analyses revealed improved glucose tolerance, reduced insulin intolerance, enhanced insulin sensitivity, and reduced insulin resistance in hemin-treated GK rats. " 05/01/2009 - "Correspondingly, hemin improved ip glucose tolerance, reduced insulin intolerance, and lowered insulin resistance (homeostasis model assessment of insulin resistance), and the inability of insulin to enhance GLUT4 was overturned. "
4.	Proteinuria 11/01/2004 - "We found that treatment with hemin led to a significant reduction of proteinuria and remarkable amelioration of glomerular lesions accompanied by decreased immune depositions. " 03/01/2000 - "In contrast, the administration of hemin, an HO inducer, ameliorated the Ang II-induced decrease in GFR (2.4+/-0.2 mL/min) and increase in proteinuria (9.3+/-4.5 mg/d). " 12/01/1999 - "The beneficial effect of hemin treatment on proteinuria could be linked to downregulation of iNOS." 12/01/1999 - "iNOS activity in glomeruli was significantly reduced in hemin-treated nephritic animals in which proteinuria was also attenuated without a change in monocyte/macrophage infiltration. " 03/01/1998 - "In ANTN proteinuria was reduced at day 1 and day 4 (36 +/- 11 vs. 60 +/- 15 and 36 +/- 7 vs. 86 +/- 9 mg protein/24 hr, respectively, P < 0.001), glomerular thrombi were reduced by hemin at day 1 and 4 (1.5 +/- 2.7 vs. 2.7 +/- 0.2 and 1.3 +/- 0.01 vs. 2.9 +/- 0.02, respectively, P < 0.001) and glomerular macrophage infiltration was reduced on day 4 (11.2 +/- 0.8 cells/glom; control 15.9 +/- 0.8, P < 0.01). "
5.	Malaria 04/21/2015 - "Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. " 12/01/2015 - "Ten of the Malaria Box compounds demonstrated significant inhibition of β-hematin formation. " 12/01/2015 - "Identification of β-hematin inhibitors in the MMV Malaria Box." 11/01/2015 - "The malaria parasite blocks hematin-induced lysis by biocrystallization, a process that converts hematin into insoluble and chemically inert crystals. " 11/07/2013 - "Therefore, this work demonstrates experimentally and theoretically the potential of tuning the core-shell Fe3O4@Ag for achieving the efficient magnetic field-enriched SERRS detection of β-hematin for early malaria diagnosis. "

Related Drugs and Biologics

1.	Creatinine
2.	Glucose (Dextrose)
3.	Insulin (Novolin)
4.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
5.	Carbon Monoxide
6.	tin protoporphyrin IX
7.	Glutathione (Reduced Glutathione)
8.	Interleukin-10 (Interleukin 10)
9.	Heme Oxygenase-1
10.	Hemoglobins (Hemoglobin)

Related Therapies and Procedures

1.	Nephrectomy
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Intraperitoneal Injections
5.	Intravenous Infusions