Hemangioendothelioma

A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)

Also Known As:

Networked: 263 relevant articles (17 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemangioma (Angioma)
2.	Hemangiosarcoma (Angiosarcoma)
3.	Neoplasms (Cancer)
4.	Sarcoma (Soft Tissue Sarcoma)
5.	Synovial Sarcoma (Synovioma)

Experts

1.	Sen, Chandan K: 3 articles (03/2014 - 10/2004)
2.	Roy, Sashwati: 3 articles (03/2014 - 10/2004)
3.	Kutzner, Heinz: 3 articles (02/2013 - 06/2006)
4.	Gordillo, Gayle M: 2 articles (03/2014 - 10/2004)
5.	Khanna, Savita: 2 articles (03/2014 - 01/2009)
6.	Requena, Luis: 2 articles (02/2013 - 02/2008)
7.	Wang, Zeng-Feng: 2 articles (03/2012 - 12/2011)
8.	Miettinen, Markku: 2 articles (03/2012 - 12/2011)
9.	Kardum-Skelin, Ika: 2 articles (09/2011 - 03/2010)
10.	Kocman, Branislav: 2 articles (09/2011 - 03/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemangioendothelioma:

1.	Interleukin-2 (IL2)IBA 08/01/1991 - "A case of Malignant Hemangioendothelioma (MHE) effectively treated with intra-arterial continuous infusion of recombinant interleukin-2 (rIL-2) was experienced. " 08/01/1991 - "[A case of malignant hemangioendothelioma effectively treated with intra-arterial continuous infusion of interleukin-2]." 08/01/1991 - "[A case of malignant hemangioendothelioma effectively treated with intra-arterial continuous infusion of interleukin-2]." 06/01/2000 - "Spindle cell hemangioendothelioma: successful treatment with recombinant interleukin-2." 11/01/1995 - "The administration of interleukin-2 (IL-2) has recently been reported to be favorable for treating malignant hemangioendothelioma (MHE). "
2.	Sirolimus (Rapamycin)FDA Link 12/01/2015 - "Sirolimus proved to be effective in children with complicated lymphatic or lymphatico-venous malformations and kaposiform hemangioendotheliomas. " 08/10/2012 - "Efficacy of rapamycin for refractory hemangioendotheliomas in Maffucci's syndrome." 12/01/2015 - "Recently, the successful use of sirolimus has been reported in children with lymphatic malformations and kaposiform hemangioendotheliomas. " 01/01/2013 - "The aim of this study was to assess the role of rapamycin-insensitive companion of mTOR (Rictor) in control of vascular tumor malignant biological behavior and cell signaling mechanism in Mouse Hemangioendothelioma Endothelial Cells (EOMA cells) and nude mouse model. " 12/01/2014 - "Low-concentration rapamycin (1 nM) inhibited hemangioendothelioma endothelial cell proliferation and migration in vitro and vascular tumor growth in vivo. "
3.	Propranolol (Inderal)FDA LinkGeneric 03/01/2013 - "Propranolol as a first-line treatment for diffuse infantile hepatic hemangioendothelioma." 09/01/2011 - "Curiously, also the liver hemangioendothelioma completely resolved after starting propranolol. " 09/01/2011 - "As for other infantile hemangiomas, propranolol proved to be an effective, safe, and well-tolerated treatment for PH. Its role in liver hemangiomas and hemangioendotheliomas should also be taken into account."
4.	Interferon-alpha (Interferon Alfa)FDA Link 02/01/2002 - "Hemangioendothelioma: successful therapy with interferon-alpha: a study in Association with the Italian Pediatric Haematology/Oncology Society (AIEOP)." 03/01/1997 - "Hepatic hemangioendothelioma of infancy: treatment with interferon alpha." 03/01/2011 - "Successful treatment of pulmonary arteriovenous malformation and infantile hepatic hemangioendothelioma with alpha-interferon." 10/01/2006 - "Hepatic hemangioendothelioma treatment options consist of corticosteroids, alpha-interferon, surgical resection, and liver transplantation. " 12/01/2009 - "Successful treatment of retroperitoneal infantile hemangioendothelioma with Kasabach-Merritt syndrome using steroid, alpha-interferon, and vincristine."
5.	O-(chloroacetylcarbamoyl)fumagillol (TNP 470)IBA 02/01/1995 - "In this study, AGM-1470 was safe and highly effective in the treatment of hemangioendothelioma. " 02/01/1995 - "Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470." 02/01/1995 - "The effectiveness of AGM-1470, a potent inhibitor of angiogenesis derived from the fungal product fumagillin, was tested in a mouse model of hemangioendothelioma. "
6.	Dermatofibrosarcoma protuberansIBA 11/01/2011 - "Diagnoses covered include undifferentiated high-grade pleomorphic sarcoma, fibrosarcoma, dermatofibrosarcoma protuberans, liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, clear cell sarcoma, hemangioendothelioma, hemangiopericytoma, angiosarcoma, and leiomyosarcoma." 10/01/2003 - "Positive results by tumor subtype were as follows: (1) nerve sheath tumors: malignant peripheral nerve sheath tumor (7/10), neurofibromas (10/10), and perineuriomas (3/3); (2) (Myo) fibroblastic tumors: malignant fibrous histiocytoma (18/20), low-grade fibromyxoid sarcomas (8/9), fibromatoses (7/7), and desmoplastic fibroblastomas (2/2); (3) vascular tumors: angiosarcomas (4/4), hemangioendotheliomas (3/5), and hemangiomas (3/4); and (4) other non-nerve sheath tumors: pleomorphic liposarcoma (4/4), dermatofibrosarcoma protuberans (2/5), rhabdomyosarcomas (2/2), synovial sarcomas (8/8), melanomas (1/2). "
7.	bevacizumabFDA Link 02/18/2009 - "The results suggest that topically applied Avastin provides an effective and safe approach to treat hemangioendotheliomas and might be used as a novel treatment of angiomatous diseases in the future." 02/18/2009 - "Investigated the efficacy of Avastin on murine hemangioendothelioma in vitro and in vivo using a mouse hemangioendothelioma-derived cell line----EOMA. " 01/01/2011 - "Bevacizumab for recurrent hemangioendothelioma." 02/18/2009 - "[Therapeutic effects of Avastin on the murine hemangioendothelioma]."
8.	Recombinant Interferon Type IIBA 07/01/1990 - "Recently, it has been found that recombinant interferon alfa is effective in treating pulmonary hemangiomatosis, as well as other variants of hemangiomatous disease such as hemangioendotheliomas. "
9.	Thyroid HormonesIBA 01/01/2007 - "We report a unique case of a 3-mo-old female with consumptive hypothyroidism and liver hemangioendothelioma who required pharmacological doses of thyroid hormones and was cured following liver transplantation. "
10.	beta Adrenergic ReceptorsIBA 01/01/2013 - "Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma." 01/01/2013 - "As infantile hemangiomas are reported to express high levels of beta adrenergic receptors, we examined the expression of these receptors on more aggressive vascular tumors such as hemangioendotheliomas and angiosarcomas, revealing beta 1, 2, and 3 receptors were indeed present and therefore aggressive vascular tumors may similarly show increased susceptibility to the inhibitory effects of beta blockade. "

Therapies and Procedures

1.	Liver Transplantation 09/01/2011 - "Hemangioendothelioma of the liver is characterized by multifocality, which excludes resection; thus, liver transplantation is the method of choice. " 03/01/2010 - "Epitheloid hemangioendothelioma in patient with liver transplantation." 08/01/2009 - "Neonates with severe infantile hepatic hemangioendothelioma: limitations of liver transplantation." 01/01/2008 - "Long-term outcomes following liver transplantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005." 09/01/2005 - "A 22-year-old Caucasian patient underwent living-donor liver transplantation (LDLT) for hepatic hemangioendothelioma in a healthy liver. "
2.	Radiotherapy 01/01/1994 - "This is a case of a young woman with a low grade malignant hemangioendothelioma of bone, who is considered cured after more than 8 years of follow-up post radiotherapy. " 08/01/2014 - "The benefit of radiotherapy (RT) for unresectable hemangioendotheliomas or patients with a high risk of local recurrence is unclear. " 12/01/2006 - "[Spindle-cell hemangioendothelioma of the pharynx managed by radiotherapy]." 01/01/1994 - "Low grade malignant hemangioendothelioma of bone: a disease potentially curable with radiotherapy." 01/01/1983 - "Infantile hepatic hemangioendothelioma treated by radiotherapy."
3.	Intralesional Injections 06/01/1991 - "A malignant hemangioendothelioma (MHE) developed on the frontal scalp of an 83-year-old woman was treated with intralesional injection of recombinant interleukin-2 (rIL-2, TGP-3, Takeda Chemical Industries LTD, Osaka) which had lead the lesion to complete remission for 2 years and 9 months. "
4.	Homologous Transplantation (Allograft) 04/01/1995 - "This study reports the 7-year follow-up of an L5 vertebral hemangioendothelioma treated with tumor excision and allograft reconstruction stabilized with transpedicular fixation. "
5.	Aftercare (After-Treatment) 11/01/2010 - "This study aims to analyze computed tomography (CT) and magnetic resonance (MR) imaging features of infantile hepatic hemangioendotheliomas before and after treatment. "