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Hemangioma (Angioma)

A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)

Also Known As:

Angioma; Hemangiomas; Chorangioma; Chorangiomas; Chorioangiomas; Hemangiomas, Histiocytoid; Hemangiomas, Intramuscular; Histiocytoid Hemangioma; Histiocytoid Hemangiomas; Intramuscular Hemangioma; Intramuscular Hemangiomas; Chorioangioma; Hemangioma, Histiocytoid; Hemangioma, Intramuscular

Networked: 3512 relevant articles (378 outcomes, 254 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Vascular Tissue Neoplasms: 83
    - Hemangioma: 3512

Related Diseases

1.	Neoplasms (Cancer)
2.	Vascular Malformations
3.	Neoplasm Metastasis (Metastasis)
4.	Hemangioma (Angioma)
5.	Telangiectasis (Telangiectasia)

Experts

1.	Frieden, Ilona J: 25 articles (02/2015 - 03/2002)
2.	Mulliken, John B: 24 articles (01/2015 - 03/2002)
3.	Bischoff, Joyce: 16 articles (08/2015 - 02/2004)
4.	Drolet, Beth A: 16 articles (07/2014 - 03/2006)
5.	Powell, Julie: 15 articles (02/2015 - 01/2006)
6.	Ma, Gang: 12 articles (04/2015 - 03/2008)
7.	Chen, Hui: 12 articles (04/2015 - 03/2008)
8.	Blei, Francine: 11 articles (12/2015 - 03/2002)
9.	Pope, Elena: 11 articles (09/2015 - 01/2007)
10.	Waner, Milton: 11 articles (09/2015 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemangioma:

1.	Propranolol (Inderal)FDA LinkGeneric 10/01/2014 - "The β-blocker propranolol was discovered to be highly effective for the treatment of infantile hemangiomas (IHs), since 2008. " 05/01/2014 - "After initiation of propranolol, most hemangiomas show evidence of significant improvement relatively rapidly, often within days. " 01/01/2014 - "Propranolol is highly effective in the treatment of infantile hemangioma (IH), but important clinical and pharmacological data are lacking. " 01/01/2014 - "Oral propranolol (PRN) has recently been shown to be highly effective for infantile hemangiomas (IHs), and is currently recommended as the first-line treatment of complicated IHs. " 01/01/2013 - "Recent reports of propranolol for the treatment of hemangiomas have led many physicians to question the best treatment strategy for children with vision-threatening hemangiomas. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/2002 - "Alarming hemangiomas can be successfully treated with corticosteroids. " 06/01/2007 - "Oral systemic corticosteroids are the mainstay of treatment for problematic hemangiomas; however, current information is based on anecdotal experience and retrospective studies. " 03/01/1998 - "However, only 2/3 of these life-threatening hemangiomas regress or are stabilized with corticosteroids: and for others there is no regularly safe and effective treatment. " 05/28/1992 - "About a third of these life-threatening hemangiomas respond to treatment with corticosteroids, but for the others there is no safe and effective treatment. " 01/01/2015 - "Six children treated with intralesional corticosteroids for problematic hemangiomas were included in the study. "
3.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 06/01/2004 - "The long-term results of patients with active choroidal hemangioma demonstrate that PDT is a most effective and safe treatment option. " 01/01/2013 - "PDT is effective in eliminating the subretinal fluid and improving vision in patients with circumscribed choroidal hemangioma." 01/01/2014 - "Overlapping-spot PDT under appropriate treatment parameters and strategies is as effective and safe as single-spot PDT for treating symptomatic circumscribed choroidal hemangioma. " 09/01/2003 - "Further studies investigating the efficacy of PDT-BPD for human hemangiomas are warranted." 10/01/2014 - "The PDT decreases the leaking of the fluid from hemangioma and decreases the size of hemangioma."
4.	Timolol (Blocadren)FDA LinkGeneric 08/01/2015 - "Topical beta-blockers such as timolol appear to be effective in treating small, superficial infantile hemangiomas. " 03/01/2012 - "The treatment outcome of our cases indicates that timolol gel is well-tolerated and effective for the therapy for infantile hemangioma. " 04/01/2015 - "Timolol has recently been reported to be an effective and safe treatment for small and superficial infantile hemangiomas (IH). " 06/01/2013 - "Timolol maleate 0.5% gel is a safe and effective medication for treating superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks. " 05/01/2012 - "Topical timolol is effective and safe in the treatment of superficial periocular infantile hemangioma. "
5.	Interferon-alpha (Interferon Alfa)FDA Link 12/01/1997 - "Interferon alfa has been used successfully to treat life-threatening hemangiomas, possibly by means of its antiangiogenic activity. " 08/01/2009 - "Interferon-alpha appears to be an effective and well-tolerated treatment for alarming hemangiomas in infancy." 02/01/2000 - "Interferon alpha is an effective treatment for hemangiomas. " 10/01/1999 - "Interferon alfa is effective for treatment of complicated hemangiomas but may cause serious neurological side effects. " 10/01/1993 - "alpha-Interferon, an angiogenesis inhibitor, is effective in the treatment of life-threatening hemangiomas. "
6.	Retinaldehyde (Retinal)IBA 07/01/2006 - "TTT could be an effective treatment for retinal hemangioma." 02/01/2009 - "Our study reports a previously described family (IFCAS-07) with 12 members affected by autosomal dominant cavernous angiomas: 11 had CCM either alone or associated with hepatic or retinal angiomas, and one had only hepatic angioma. " 01/01/2016 - "RETINAL RACEMOSE HEMANGIOMA WITH FOCAL MACULAR INVOLVEMENT." 10/01/2014 - "The authors present a case of a 34 years old male patient with diagnosed retinal hemangioma localized on the optic disc. " 08/01/2014 - "Eight eyes of 8 patients (3 male and 5 female, with a mean age of 36 years [range 22-80 years]) were treated for symptomatic papillary retinal hemangioma. "
7.	verteporfin (Visudyne)FDA Link 09/01/2005 - "Verteporfin therapy for choroidal hemangioma: a long-term follow-up." 10/01/2003 - "Verteporfin therapy may be useful in diffuse choroidal hemangiomas." 11/01/2003 - "The present series demonstrates that even limited, low-irradiance, single-spot photodynamic therapy with verteporfin is an effective first-line treatment for choroidal hemangiomas." 11/01/2001 - "Photodynamic therapy with verteporfin is effective in eliminating subretinal fluid and improving vision in patients with circumscribed choroidal hemangioma." 05/01/2013 - "Recurrent leakage after Visudyne photodynamic therapy for the treatment of circumscribed choroidal hemangioma."
8.	Kasabach-Merritt SyndromeIBA 01/01/1999 - "We conclude that transcutaneous arterial embolization is an effective and safe treatment in this neonate and should be considered for the treatment of control high-output cardiac failure and coagulopathy in infants with hemangioma and Kasabach-Merritt syndrome." 01/01/2004 - "Kasabach-Merritt syndrome must be suspected in patients with large hemangiomas with associated bone lesions, and appropriate coagulation studies should be obtained before any operative management. " 01/01/2015 - "Comprehensive therapy for hemangioma presenting with Kasabach-Merritt syndrome in the maxillofacial region." 12/01/2013 - "Transarterial embolization of a cervicofacial hemangioma associated with Kasabach-Merritt syndrome in a premature neonate." 01/01/2013 - "However, the vascular lesions associated with Kasabach-Merritt syndrome, such as hemangioma, can be life-threatening. "
9.	bleomycetinIBA 07/01/2014 - "The aim of the present study was to determine the molecular mechanism(s) underlying the therapeutic effects of pingyangmycin against infantile hemangiomas. " 01/01/2013 - "[Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study]." 12/01/2015 - "Pingyangmycin (PYM), a glycopeptide antibiotic, has been recommended as a stand treatment for hemangioma. " 07/01/2014 - "The data demonstrated that the pro‑apoptotic activity of pingyangmycin against infantile hemangiomas involves p53 pathway activation. " 07/01/2014 - "Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway."
10.	ArgonIBA 02/01/1983 - "It has been proven that intense argon laser light is very useful in the treatment of port-wine hemangiomas and tattoos. " 01/01/1985 - "The technique of argon laser treatment of port wine hemangiomas has been greatly improved since first used in the medical field. " 05/01/1989 - "Preliminary study of the vascular dynamics of port-wine hemangioma with therapeutic implications for argon laser treatment." 01/01/2002 - "The tumoral surface was covered by Argon laser spots with the central avascular area spared in the case of subfoveal hemangioma. " 10/01/1996 - "The hemangioma was treated successfully by argon laser in a single outpatient session with no postoperative complications. "

Therapies and Procedures

1.	Lasers (Laser) 09/01/2010 - "Letter regarding early laser treatment of periorbital infantile hemangiomas may work, but is it really the best treatment option?" 09/01/2010 - "Letter regarding early laser treatment of periorbital infantile hemangiomas may work, but is it really the best treatment option?" 05/01/2010 - "Commentary: Early laser treatment of periorbital infantile hemangiomas may work, but is it really the best treatment option?" 07/01/2013 - "Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. " 04/01/2012 - "Combined therapy with long pulsed 1064nm laser and oral corticosteroid is effective for infantile deep-seated hemangiomas in the proliferating stage."
2.	Dye Lasers 01/01/2012 - "Pulsed dye laser has proven effective in the treatment of ulcerated hemangiomas. " 01/01/2014 - "Pulsed dye laser has been proved to be fairly effective in the treatment of infantile hemangioma. " 01/01/2014 - "595 nm pulsed dye laser provides a safe and effective modality with lower morbidity for hand hemangioma." 02/01/2006 - "Pulsed dye laser (PDL) has been reported to be safe and effective in the management of superficial hemangiomas of infancy. " 05/01/2000 - "To study in a compared manner the efficacy of flashlamp-pumped pulsed dye laser (FPDL) therapy for superficial and mixed hemangiomas. "
3.	Photochemotherapy (Photodynamic Therapy) 01/01/2014 - "Photodynamic therapy was effective in the treatment of infantile hemangioma. " 09/01/2002 - "Photodynamic therapy seems to be effective in the management of circumscribed choroidal hemangioma. " 01/01/2014 - "The authors investigated the efficacy of photodynamic therapy against infantile hemangioma using a hemangioma animal model. " 01/01/2009 - "Prospective clinical trial evaluating the efficacy of photodynamic therapy for symptomatic circumscribed choroidal hemangioma." 11/01/2006 - "To evaluate the safety and efficacy of photodynamic therapy in the management of symptomatic circumscribed choroidal hemangiomas (CCH) with exudative activity. "
4.	Vertebroplasty 01/01/2004 - "The results of the treatment indicate that puncture vertebroplasty is highly effective and safe in treating patients with hemangiomas of the vertebral bodies." 10/01/2013 - "Treatment of atlantoaxial hemangioma with vertebroplasty through anterior approach is a safe and effective method. " 12/01/2004 - "Treatment of vertebral hemangioma with percutaneous vertebroplasty is safe and effective with minimal invasion." 12/01/2004 - "To investigate the efficacy of percutaneous vertebroplasty in the treatment of vertebral hemangioma. " 01/01/2012 - "This study aimed to illustrate the validity of treatment with percutaneous vertebroplasty (PVP) in patients with symptomatic vertebral hemangiomas (VHs). "
5.	Radiotherapy 08/01/1977 - "In about 60%, radiotherapy resulted in permanent significant improvement or freedom of angioma related symptoms. " 06/01/2012 - "The purpose of this study was to assess the efficacy of hypofractionated stereotactic radiotherapy in patients with large cavernous sinus hemangiomas. " 06/01/2012 - "Phase II study to assess the efficacy of hypofractionated stereotactic radiotherapy in patients with large cavernous sinus hemangiomas." 01/01/2001 - "The efficacy of radiotherapy for vertebral hemangiomas." 12/01/1996 - "[The efficacy of radiotherapy in vertebral hemangiomas]."