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Sirolimus (Rapamycin)

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Also Known As:
Rapamycin; Rapamune; AY 22-989; I-2190A; AY 22 989; AY 22989; I 2190A; I2190A
Networked: 9779 relevant articles (965 outcomes, 1688 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Serruys, Patrick W: 83 articles (08/2022 - 06/2002)
2. Park, Seung-Jung: 39 articles (11/2021 - 02/2005)
3. Leon, Martin B: 39 articles (03/2015 - 10/2003)
4. Kastrati, Adnan: 38 articles (10/2021 - 08/2004)
5. Valgimigli, Marco: 35 articles (01/2022 - 05/2004)
6. Windecker, Stephan: 35 articles (01/2022 - 01/2003)
7. Liu, Yang: 34 articles (07/2021 - 12/2011)
8. Blagosklonny, Mikhail V: 34 articles (12/2020 - 09/2006)
9. Kim, Young-Hak: 32 articles (01/2021 - 02/2005)
10. Xu, Bo: 29 articles (01/2022 - 08/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Tuberous Sclerosis (Bourneville's Disease)
3. Inflammation (Inflammations)
4. Angiofibroma
5. Coronary Artery Disease (Coronary Atherosclerosis)

Related Drugs and Biologics

1. Everolimus
2. TOR Serine-Threonine Kinases
3. Sirolimus (Rapamycin)
4. MTOR Inhibitors
5. Mechanistic Target of Rapamycin Complex 1
6. trans-sodium crocetinate (crocetin)
7. Polymers
8. Cyclosporine (Ciclosporin)
9. Paclitaxel (Taxol)
10. Tacrolimus (Prograf)

Related Therapies and Procedures

1. Stents
2. Therapeutics
3. Transplantation
4. Liver Transplantation
5. Drug-Eluting Stents