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Ancitabine

Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.

Also Known As:

Cyclo-C; NSC-145,668; NSC-145668; U-33,624A; U-33624A; Cyclo C; CycloC; NSC 145,668; NSC 145668; NSC145,668; NSC145668; U 33,624A; U 33624A; U33,624A; U33624A; Anhydro-Ara-C; Cyclocytidine; 6H-Furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, (2R-(2alpha,3beta,3abeta,9abeta))-

Networked: 32 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Leukemia 11/01/1980 - "[Results of cooperative clinical studies of cyclocytidine in leukemia in children and adults]." 07/01/1982 - "[Comparative study of 2 preparations of cyclocytidine (USSR, Japan) in leukemia patients]." 08/01/1973 - "[Treatment of acute leukemia with 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride (cyclocytidine) (author's transl)]." 01/01/1990 - "Comparison of some biochemical parameters of arabinosylcytosine and cyclocytidine in L1210 murine leukemia cells." 12/01/1974 - "[Anhydro-arabinosylcytosine (cyclocytidine) in the therapy of acute leukemia]."
2.	Neoplasms (Cancer) 06/01/1985 - "The anti-tumor agent, cyclocytidine (CC), given daily for 3 days in an ip dose of 500 mg/kg, also caused a two- to threefold increase in [Ca] of the submandibular gland when rats were more than 12 days of age at the time of the initial injection of the drug, but in rats younger than this age, CC caused no change in the [Ca] of the submandibular gland. " 06/01/1972 - "Antitumor activity of cyclocytidine in a variety of tumors." 08/01/1991 - "administration of a single dose (500 mg/kg body weight) of the anti-tumor agent, cyclocytidine (CC). " 04/01/1976 - "Combined effect of cyclocytidine and lentinan of spontaneous mammary tumors in mice." 01/01/1984 - "Evaluation of cyclocytidine in reinduction and maintenance therapy of children with acute nonlymphocytic leukemia previously treated with cytosine arabinoside: a report from Children's Cancer Study Group."
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/01/1991 - "Amsacrine (AMSA) and cyclocytidine were studied as retrieval therapy in 122 pediatric patients with acute nonlymphoblastic leukemia (ANLL). " 05/01/1991 - "Successful reinduction therapy with amsacrine and cyclocytidine in acute nonlymphoblastic leukemia in children. " 10/01/1987 - "On the other hand, in the development of its derivertive compounds ancitabine or enocitabine (BH-AC) were induced to a treatment of acute myelogenous leukemia. " 01/01/1984 - "A single daily subcutaneous dose of Cyclo-C was found to be as efficacious as Ara-C given intravenously every 12 hr. The single dose schedule provides a convenient way to treat patients with relapsed ANLL in the outpatient setting." 01/01/1984 - "Evaluation of cyclocytidine in reinduction and maintenance therapy of children with acute nonlymphocytic leukemia previously treated with cytosine arabinoside: a report from Children's Cancer Study Group."
4.	Infection 09/01/1982 - "Cyclo-C was effective in all the cases with acute infections, although it had no benefit on the course of chronic CMV infection with irreversible damages. " 09/01/1982 - "From the present small open study, further evaluation of Cyclo-C as an antiviral agent especially in acute CMV infections is warranted." 09/01/1982 - "[Cyclocytidine therapy for the herpes-group virus infection in children. " 02/01/1977 - "The antivaccinial activity of 3'-O-decanoyl cyclo-C was also compared with that of other compounds against encephalitis and dermal tail lesions in mice caused by vaccinia virus infection. " 09/01/1982 - "Cyclocytidine (Cyclo-C) was evaluated as an antiviral chemotherapeutic agent in 10 children with herpes-group virus infections. "
5.	Encephalitis (Encephalitis, Rasmussen) 02/01/1977 - "Among the derivatives tested, 3'-O-decanoyl cyclo-C hydrochloride was the most effective against herpes simplex virus-induced encephalitis in mice when the drug was administered directly into infected brains of mice (target-organ treatment). " 02/01/1977 - "The antivaccinial activity of 3'-O-decanoyl cyclo-C was also compared with that of other compounds against encephalitis and dermal tail lesions in mice caused by vaccinia virus infection. "

Related Drugs and Biologics

1.	Ancitabine
2.	Cytarabine (Cytosar-U)
3.	Daunorubicin (Cerubidine)
4.	Prednisolone (Predate)
5.	Amsacrine (AMSA)
6.	Cytostatic Agents
7.	Ganciclovir (Cytovene)
8.	Azacitidine (5 Azacytidine)
9.	pyrimidine
10.	fazarabine

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)
2.	Intravenous Infusions
3.	Intraperitoneal Injections