Extrahepatic Cholestasis

05/01/2011 - "  In extrahepatic cholestasis, the elevation of LS which is probably attributed to the increased hydrostatic pressure in the liver, correlates positively with the accumulation of bilirubin but negatively with damage of hepatocytes indicated by ALT levels. "
02/01/1995 - "In extrahepatic cholestasis a high serum bilirubin level is a distinct factor predisposing to aminoglycoside nephrotoxicity."
04/01/1990 - "Infants with extrahepatic cholestasis were found to have statistically higher serum bile acid and bilirubin concentrations. "
04/01/1988 - "Eighteen patients with total extrahepatic cholestasis undergoing PTCD were classified into three groups, depending on the bilirubin decrease rate at two weeks after PTCD. "
05/01/1979 - " A disproportionate elevation of serum bilirubin vis-a-vis serum enzymatic activities separated potential IHC cases into intra- and extrahepatic cholestasis. "

05/01/2012 - "This study aimed to investigate the mtDNA alterations that occurred during liver injury in patients with extrahepatic cholestasis. "
05/01/2012 - "Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A."

04/01/1981 - "The plasma clearance of pancuronium in patients with extrahepatic cholestasis was 16% lower than in a control group (1.47 +/- 0.11 ml min-1 kg-1 v. 1.76 +/- 0.21 ml min-1 kg-1), but the difference was not significant. "
04/01/1981 - "The increase of T 1/2 beta pancuronium in patients with extrahepatic cholestasis was mainly a consequence of the increase in the volume of distribution. "
04/01/1981 - "A significant increase in the elimination half-life T 1/2 beta of pancuronium (from 141 to 224 min) and a significant increase in the volume of the peripheral compartment (V2) was found in patients with extrahepatic cholestasis when compared with control patients. "
04/01/1981 - "Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis."
08/01/1980 - "Inhibition of hepatic uptake of Org 6368 and pancuronium in extrahepatic cholestasis might explain the significant alterations in the pharmacokinetics of the two steroid neuromuscular blocking drugs. "

01/01/1993 - "This was particularly evident in 7 subjects with extrahepatic cholestasis and an abnormal pattern of hepatic protein synthesis or impaired clearance of plasma protein C would appear to develop in such pathological conditions."

01/01/1993 - "Minimal biliary excretion and enterohepatic recirculation of metoclopramide in patients with extrahepatic cholestasis."
01/01/1993 - "The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bile duct. "

03/01/1993 - "Biliary hyperpressure in rat extrahepatic cholestasis alters horseradish peroxidase biliary excretion."
03/01/1993 - "1. The authors investigated the effect of two extrahepatic cholestasis models (one by bile duct ligation and the other by choledocho-jugular fistula) on the hepatic clearance of horseradish peroxidase in male Sprague-Dawley rats divided into four groups. "

05/01/2012 - "Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A."

09/01/2014 - "Eighteen adults over 17 years with extrahepatic cholestasis were included in the study on a prospective basis, and we determined in them biochemical liver function parameters and lipoprotein metabolism parameters, particularly Lp(a) before and after unblocking. "
12/01/1986 - "Bile acid transport by serum lipoproteins in patients with extrahepatic cholestasis."
01/01/1977 - "An abnormal lipoprotein can be detected in the sera of patients suffering from intra- and extrahepatic cholestasis. "
01/01/2015 - "Our study showed that the CA19.9 level of bile fluid in extrahepatic cholestasis due to biliary stone was significantly higher than those with cholangiocarcinoma, as is the biliary level of TG, cholesterol, high-density lipoprotein (HDL) and direct bilirubin. "

07/01/1996 - "Our study indicates that Ito cells, transitional and endothelial cells are the main source of collagens type III and IV in the space of Disse in extrahepatic cholestasis in humans."
07/01/1996 - "The localization of collagens type III and type IV in human liver in extrahepatic cholestasis was investigated immunohistochemically in the present study. "
06/01/1991 - "This study demonstrates that experimental extrahepatic cholestasis in the rat induces periportal fibrosis and continuous deposition of collagen IV in the sinusoids. "
12/01/1990 - "These results show that hepatic fibrosis induced by experimental extrahepatic cholestasis in rat disappears in less than 3 weeks after relief of bile duct obstruction, suggesting that an active degradation of matrix protein occurs, except for collagen IV in the sinusoid."

11/01/1997 - "The aim of this study was to evaluate the effect of extrahepatic cholestasis on the pharmacokinetics of digoxin. "
01/01/1996 - "The aim of the study was to evaluate the pharmacokinetics of digoxin administered both intravenously and into the stomach, in the state of mechanical, extrahepatic cholestasis. "
01/01/1996 - "[The effect of experimental extrahepatic cholestasis on absorption, distribution and elimination of digoxin]."
01/01/1996 - "Basing on the results of the present study, the following statements could be expressed: (1) experimental, extrahepatic jaundice alters the pharmacokinetics of digoxin given intragastrically as well as intravenously; (2) the administration of therapeutic dose of digoxin in the state of mechanical jaundice may lead to its overdose; (3) obstruction of the common bile duct should indicate the necessity of monitoring the serum concentration of digoxin; (4) extrahepatic cholestasis may induce hepatorenal syndrome."

08/01/1989 - "Endoscopic sphincterotomy is a relatively safe and effective means of relieving extrahepatic cholestasis; however, its comparison with surgical techniques needs long-term, randomized studies."
01/01/1980 - "Endoscopic sphincterotomy is a relatively safe and effective method for treatment of extrahepatic cholestasis. "
04/01/1984 - "[Extrahepatic cholestasis: endoscopic papillotomy--indications]."
03/13/1982 - "Endoscopic sphincterotomy is a new procedure for the management of extrahepatic cholestasis. "
05/01/2011 - "The aim of this study was to evaluate LS in patients with extrahepatic cholestasis due to choledocholithiasis before and after endoscopic sphincterotomy and stone removal. "

06/01/1998 - "In this study, the effects of extrahepatic cholestasis induced by bile duct ligation for 4 days on the uptake of [3H]MPP+ by rat freshly isolated hepatocytes and liver slices were determined. "
08/01/1993 - "The present study was carried out to investigate the biochemical and morphological changes in the liver after ligation of the hepatic artery (HA) in the presence and in the absence of extrahepatic cholestasis (EHC). "
01/01/1992 - "The present study was performed to correlate changes in hepatic morphology with hepatic artery ligation (HAL) in the presence of extrahepatic cholestasis (EHC). "
01/01/1990 - "The objective of the present study was to investigate hepatic alterations due to hepatic artery ligation in rats with chronic extrahepatic cholestasis. "
08/01/2015 - "Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats."

03/01/2005 - "ERCP procedure is quite an effective and safe method for diagnosis and treatment in patients with Billroth II anastomosis and extrahepatic cholestasis in spite of all difficulties."

01/01/1993 - "The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bile duct. "

10/01/1991 - "Extrahepatic cholestasis was confirmed by either exploratory laparotomy or autopsy in 12 of 13 cases without bile drainage, with only one false-positive result. "
10/01/1988 - "The diagnosis was based on the absence of extrahepatic cholestasis at laparoscopy, laparotomy and/or post-mortem examination, and the presence of specific liver lesions i.e. "
01/01/1981 - "Extrahepatic cholestasis was excluded at laparotomy. "
01/01/1977 - "248 registrations at 13 laparotomies in 6 mongrel dogs showed that extrahepatic cholestasis had no statistically significant influence on the blood flow as compared to normal. "