Gold

A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.

Networked: 7424 relevant articles (285 outcomes, 862 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Vestbo, Jørgen: 31 articles (12/2015 - 08/2002)
2.	El-Sayed, Mostafa A: 30 articles (03/2014 - 05/2005)
3.	Silverman, Edwin K: 25 articles (01/2016 - 01/2010)
4.	Che, Chi-Ming: 22 articles (11/2014 - 07/2003)
5.	Huang, Xiaohua: 19 articles (06/2015 - 05/2005)
6.	Wouters, Emiel F M: 18 articles (05/2015 - 01/2005)
7.	Lange, Peter: 17 articles (12/2015 - 08/2002)
8.	Lundbäck, Bo: 17 articles (11/2015 - 03/2004)
9.	Churchyard, Gavin J: 17 articles (04/2015 - 03/2002)
10.	Crapo, James D: 16 articles (10/2015 - 02/2010)

Related Diseases

1.	Neoplasms (Cancer) 07/11/2014 - "The significant improvement in sensitivity illustrates that combining gold nanoparticles with the on-site fabricated aligned MWCNT array represents a promising platform for achieving sensitive biosensor for fast mutation screening related to most human cancer types. " 01/08/2013 - "Statistically significant reduction of gold accumulation was observed in acidic tumors and kidney when pH-insensitive K-pHLIP was used as a vehicle, suggesting an important role of pH in the pHLIP-mediated targeting of gold nanoparticles. " 11/01/2015 - "Our results have demonstrated that TNF-labeled gold nanoparticles combined with single or fractionated high-dose radiation therapy is effective in reducing IFP and tumor growth and shows promise for clinical translation." 01/08/2013 - "The pHLIP technology can substantially improve the delivery of gold nanoparticles to tumors by providing specificity of targeting, enhancing local concentration in tumors, and distributing nanoparticles throughout the entire tumor mass where they remain for an extended period (several days), which is beneficial for radiation oncology and imaging." 05/02/2012 - "Owing to the strong surface plasmon resonance absorption contributed by the gold shell, the SWNTs-Au-PEG-FA nanocomposite also offers remarkably improved photothermal cancer cell killing efficacy. "
2.	Rheumatoid Arthritis 07/01/1986 - "Although gold is one of the few therapeutic agents that has been proven effective in producing remission in patients with rheumatoid arthritis, its mechanism of action is unknown. " 03/14/2011 - "Gold(I)-based drugs have been used successfully for the treatment of rheumatoid arthritis (RA) for several years. " 04/03/1987 - "Although certain gold [Au(I)] compounds have been used effectively in the treatment of rheumatoid arthritis for some years, the molecular basis for such therapeutic action has been unclear. " 07/01/1998 - "Clinical remission in rheumatoid arthritis: efficacy of a second course of intra-muscular gold." 02/01/1998 - "Improved functional outcome in patients with early rheumatoid arthritis treated with intramuscular gold: results of a five year prospective study."
3.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2009 - "The NNT in the overall study group was 2; the same NNT was obtained in GOLD stages 2, 3, and 4, but was 8 in stage 1. PR is highly effective in improving the exercise capacity of patients with COPD, as demonstrated by a valuable NNT, with better results in patients with a more severe disease." 07/01/2014 - "The %WA fifth to first of 1.51 (sensitivity, 83%; specificity, 89%) was best for diagnosis of GOLD 3-4. Ratios of peripheral-to-central airway LA and %WA show improved correlation with COPD severity." 03/01/2005 - "The Global Initiative for Chronic Obstructive Lung Disease (GOLD) underlines that spirometry is the gold standard as the most reproducible, standardised, and objective way of measuring airflow limitation in the diagnosis and assessment of Chronic Obstructive Pulmonary Disease (COPD). " 01/01/2009 - "To understand the relative efficacy of SFC and its components by GOLD stages, we conducted a post-hoc analysis of the TORCH dataset using baseline post-bronchodilator FEV1 to segment patients into three groups: moderate COPD (GOLD stage II and above: >or= 50%; n = 2156), severe COPD (GOLD stage III: 30% to < 50%; n = 3019) and very severe COPD (GOLD stage IV: < 30%; n = 937). " 09/01/2007 - "As recently stated by the GOLD initiative, improvement in exercise tolerance is now rec ognized as an important goal of COPD treatment. "
4.	Tuberculosis (Tuberculoses) 04/22/2006 - "Overall, T-SPOT.TB produced significantly more positive results (38%, n=144, vs 26%, n=100, with QuantiFERON-TB Gold; p<0.0001), and close contacts of patients with active tuberculosis were more likely to be positive with T-SPOT.TB than with QuantiFERON-TB Gold (p=0.0010). " 09/01/2005 - "In 11 patients with active tuberculosis (5 culture-confirmed), QFT-Gold provided more positive results than the TST (66.7% vs. 33.3%; p = 0.165). " 09/01/2011 - "Among positive QuantiFERON-TB Gold patients, 25 received a full anti-tuberculosis treatment, which was effective in 15 cases (60%). " 10/01/2014 - "This article provides a detailed analysis of the origins and significance of the 1926 clinical trial of Sanocrysin, a gold compound thought at the time to be useful in the treatment of tuberculosis. " 01/01/2011 - "Both patients had a positive Quantiferon TB Gold in-tube result and improved rapidly after empiric treatment for tuberculosis. "
5.	Infection 05/01/2005 - "By bulk lyophilization the number of particles was 4 +/- 4, but by fast freezing and lyophilization the number of gold particles improved to 12 +/- 5. The loss of viral membrane was directly observed, and the in vitro loss was demonstrated to occur through three possible pathways, including (i) simultaneous release of tegument and membrane, (ii) sequential release of membrane and then tegument, and (iii) release like by in vivo infection. " 01/20/2013 - "In this study we analyzed the early events in the infection process by means of electron microscopy and immuno-gold labeling of viral particles during cell entry, and used as a new approach for infecting cells with viruses obtained directly from mosquitoes. " 03/01/2011 - "The present study aimed to use QuantiFERON TB Gold in tube (Cellestis Limited, Carnegie, Victoria, Australia) as a tool for the screening for tubercular infection in HIV-positive patients. " 09/01/2010 - "The aim of this study was to investigate latent TB infection among TA patients by the use of both TST and QFT Gold test. " 01/01/1953 - "[Infection trials with BCG strains in gold hamsters]."

Related Drugs and Biologics

1.	Auranofin (Ridaura)
2.	Salts
3.	Doxorubicin (Adriamycin)
4.	Penicillamine (Cuprimine)
5.	tiotropium (Spiriva)
6.	Methotrexate (Mexate)
7.	Gold Sodium Thiomalate (Sodium Aurothiomalate)
8.	Azathioprine (Imuran)
9.	Liposomes (Liposome)
10.	Tuberculin (PPD)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lasers (Laser)
3.	Injections
4.	Nanospheres
5.	Radiotherapy