Effect of hepatic artery ligation in rats with chronic extrahepatic cholestasis.

Abstract

Because of the liver's dependence on arterial blood to exert its metabolic functions in cirrhosis of the liver, with or without thrombosis of the portal vein, the interruption of hepatic arterial flow for the palliative treatment of malignant tumors of the liver is counterindicated. However, the effects of arterial devascularization on the cholestatic liver are not fully understood. The objective of the present study was to investigate hepatic alterations due to hepatic artery ligation in rats with chronic extrahepatic cholestasis. Serum alkaline phosphatase, bilirubin and alanine aminotransferase were measured in rats 3 h after sham operation (group A, N = 29) or ligation of the hepatic artery (group B, N = 29). Alanine aminotransferase activity was significantly higher (P less than 0.05) in group B, demonstrating acute hepatocellular damage in animals with chronic extrahepatic cholestasis.

• Authors: A F Soares, O Castro-e-Silva Júnior, L M Watanabe, J E Roselino, R Ceneviva
• Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 23 Issue 6-7 Pg. 543-5 ( 1990) ISSN: 0100-879X [Print] Brazil
• PMID: 2101073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Animals
• Cholestasis, Extrahepatic (metabolism, physiopathology)
• Hepatic Artery
• Ligation
• Liver (metabolism)
• Male
• Rats
• Rats, Inbred Strains