Second Generation Cephalosporins

07/01/2013 - "Cefuoxime, a second-generation cephalosporin, is used in the treatment of Gram-positive infections. "
01/01/2003 - "First- and second-generation cephalosporins prevent postoperative infections. "
12/01/2001 - "In general, we select second-generation cephalosporins, be cause gram-negative rod infection frequently occurs. "
12/01/1993 - "Randomized, prospective comparison of first- and second-generation cephalosporins as infection prophylaxis for cardiac surgery."
01/01/1993 - "Single dose prophylaxis with a second generation cephalosporin appears to be an appropriate strategy for infection prevention in surgery with regard to efficiency, safety and costs."

09/01/1992 - "Recently published studies have claimed improved outcomes with respect to postoperative wound infection when second-generation cephalosporins were used for prophylaxis. "
09/01/2014 - "A PAP with first-generation or second-generation cephalosporins could significantly reduce the rate of surgical site infections after thoracic surgery. "
09/01/2013 - "The aim of this study was to investigate the hypothesis that prevention of surgical site infection (SSI) is equally effective when patients receive single-dose (SD) or three-dose antibiotic prophylaxis with second-generation cephalosporin and metronidazole in elective colorectal surgery. "
01/01/2017 - "In this large cohort, the use of prophylactic cefazolin plus metronidazole resulted in lower surgical site infection rates after hysterectomy compared with cefazolin or second-generation cephalosporin."
01/01/2017 - "The unadjusted rate of surgical site infection was 1.8% (n=267) for cefazolin, 2.1% (n=49) for second-generation cephalosporin, and 1.4% (n=13) for cefazolin plus metronidazole. "

04/01/2010 - "The study aim was to compare two techniques using in post partum post-cesarean endometritis prevention: local (vaginal) intra-partum application of 0.25% Clorhexidine solution during elective cesarean deliveries vs intraoperative cesarean section antibioprevention with 2g second generation cephalosporin administered by intravenous injection after clamping the umbilical cord."
09/01/2005 - "The 5-day combination of once-daily 80 mg gentamicin with a second-generation cephalosporin is effective in patients with chorioamnionitis and endometritis, but only moderately effective in those with wound infections and septicemia."
01/01/2008 - "This is a cohort study of trends in postcesarean endometritis using data both from prospective surveillance by the infection control unit and from query of our obstetric computerized database to compare three periods of antibiotic prophylaxis: standard narrow-spectrum with intravenous first- or second-generation cephalosporin (1992-1996), clinical trial of extended-spectrum with addition of intravenous doxycycline and oral azithromycin (1997-1999), and routine use of extended-spectrum with addition of intravenous azithromycin (2001-2006) to standard cephalosporin prophylaxis. "

01/01/1996 - "Cefuroxime is a second-generation cephalosporin with in vitro activity against the organisms that are commonly associated with neurosurgical wound infections. "
05/01/2009 - "PEG-wound infection was detected in 33/103 (32.0%) patients between January 2002 and May 2004 with either second generation cephalosporins or co-amoxiclav antibiotic prophylaxis, with the commonest organisms being Pseudomonas aeruginosa (16.7%), Klebsiella species (9.9%) and methicillin-resistant Staphylococcus aureus (5.3%). "
12/01/2008 - "The recommended antibiotic prophylaxis by second-generation cephalosporins reduces the incidence of wound infection and empyema, but its effectiveness on postoperative pneumonias (POPs) after major lung resection lacks demonstration. "
09/01/2005 - "The 5-day combination of once-daily 80 mg gentamicin with a second-generation cephalosporin is effective in patients with chorioamnionitis and endometritis, but only moderately effective in those with wound infections and septicemia."
12/01/1993 - "The second-generation cephalosporin, cefuroxime, did not reduce the incidence of wound infection when compared with the first-generation cephalosporin, cefazolin. "

08/01/2003 - "Treatment of peripartum sepsis with second-generation cephalosporin is usually effective, and the outcome is good."
03/01/1998 - "First- and second-generation cephalosporins and penicillin beta-lactamase inhibitor combinations generally do not achieve sufficient concentrations to cover the most important pathogens of sepsis. "
09/01/2005 - "The 5-day combination of once-daily 80 mg gentamicin with a second-generation cephalosporin is effective in patients with chorioamnionitis and endometritis, but only moderately effective in those with wound infections and septicemia."
01/01/1996 - "Empirical treatment of septicemia with aminoglycosides combined with penicillin, ampicillin, or second-generation cephalosporins is ineffective. "