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Cefuroxime (Zinacef)

Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.

Also Known As:

Zinacef; Cephuroxime; Ketocef; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-

Networked: 741 relevant articles (102 outcomes, 123 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Barry, Peter: 4 articles (01/2014 - 03/2006)
2.	Chiu, Fang-Yao: 3 articles (04/2012 - 05/2002)
3.	Gettinby, George: 3 articles (09/2009 - 03/2006)
4.	Peterson, Magnus: 3 articles (09/2009 - 03/2006)
5.	ESCRS Endophthalmitis Study Group: 3 articles (09/2009 - 03/2006)
6.	Lees, Fiona: 3 articles (09/2009 - 03/2006)
7.	Bauhofer, A: 3 articles (05/2009 - 08/2004)
8.	Wejde, Gisela: 3 articles (05/2007 - 06/2002)
9.	Pichichero, Michael E: 3 articles (03/2007 - 04/2005)
10.	Shorstein, Neal H: 2 articles (10/2015 - 01/2013)

Related Diseases

1.	Infection 09/01/2013 - "In this study, cefuroxime appeared to be effective in prophylaxis against infections. " 01/01/1999 - "The results showed that cefuroxime was effective in the treatment (80 per cent) and prophylaxis (93.6 per cent) of the pyo-inflammatory complications and was active against the majority of the surgical infection pathogens." 01/01/1980 - "Cefuroxime appears to be an effective and well-tolerated drug for the treatment of patients with severe chest infections." 01/01/1994 - "These studies demonstrated that majority of microorganisms responsible for infection of respiratory and urinary tract is susceptible to cefuroxime and that axetil cefuroxime in suspension presents as a very useful antibiotic, especially in pediatric ambulatory treatment." 07/01/1989 - "Five infections were cured with cefuroxime monotherapy. "
2.	Pneumonia (Pneumonitis) 03/01/1996 - "The MIC value was a good predictor of clinical efficacy with a sensitivity of 100%, a specificity of 83% and a positive predictive value of 97%; the latter value indicates that therapeutic success is virtually certain when the bacterium causing pneumonia is susceptible to cefuroxime." 09/01/1994 - "This open study was designed to investigate the efficacy of cefuroxime in pediatric patients aged 3 months to 5 years with community-acquired pneumonia. " 01/01/2009 - "In February 2001, he developed pneumonia and was prescribed cefuroxime intravenously. " 09/01/2000 - "Cefuroxime can be used either orally or parenterally and it is approved in many countries for the treatment of adult pneumonia by either route. " 09/01/2000 - "Cefuroxime has been recommended as a component of treatment for community-acquired pneumonia (CAP) in guidelines produced by several groups, including the US and British Thoracic Societies. "
3.	Endophthalmitis (Ophthalmia) 10/01/2015 - "The difference was statistically significant (p = 0.03) CONCLUSIONS: The introduction of prophylactic use of intracameral cefuroxime was associated with a significant reduction in post-operative endophthalmitis rates in our centers. " 02/01/2015 - "The rate of clinical and culture-positive endophthalmitis was compared between the 2 study groups: eyes without intracameral cefuroxime (Group 1) and eyes with intracameral cefuroxime (Group 2). " 01/01/2013 - "Subsequent to the results of the European multicenter trial documenting decreased risk of endophthalmitis with intracameral cefuroxime injection at the end of surgery, similar benefit with intracameral antibiotic use has been reported in studies with large sample sizes from multiple centers around the world. " 10/01/2007 - "The ESCRS-sponsored study of postoperative endophthalmitis prophylaxis reported rates of presumed infectious postoperative endophthalmitis of 0.07% with intracameral cefuroxime treatment and 0.34% in control groups. " 02/01/2015 - "In the treatment without intracameral cefuroxime, there was a minimal, statistically insignificant increase in postoperative acute endophthalmitis (odds ratio, 1.42; 95% confidence interval, 0.53-4.02; P = .506). "
4.	Cataract (Cataracts) 01/01/2013 - "One of the included studies, the ESCRS (European Society of Cataract and Refractive Surgeons) study, was performed using contemporary surgical technique and employed cefuroxime, an antibiotic commonly used in many parts of the world. Clinical trials with rare outcomes require very large sample sizes and are quite costly to conduct; thus, it is unlikely that additional clinical trials will be conducted to evaluate currently available prophylaxis. " 09/01/2012 - "The cefuroxime solution that was prophylactically used in the ESCRS study and that is recommended for routine cataract surgery is not commercially available in Germany as a ready preparation for intraoperative application. " 04/01/2009 - "The majority of United Kingdom and Ireland Society of Cataract and Refractive Surgeons members have switched to intracameral cefuroxime, despite the absence of previously preferred practice in the study design. " 11/01/2008 - "Following findings in Sweden that supported the advantages of the use of intracameral cefuroxime, the European Society of Cataract and Refractive Surgeons (ESCRS) performed a study to confirm the Swedish results and to lead to a revision of ESCRS guidelines. " 12/01/2007 - "The ESCRS (European Society of Cataract and Refractive Surgeons) has published the results of a study using a cefuroxime injection in the anterior chamber at the end of cataract surgery. "
5.	Wound Infection (Wound Infections) 10/01/2015 - "Those receiving cefuroxime showed significantly lower incidence of wound infections (P = 0.034; risk decreased by the factor 2.88). " 01/01/2012 - "Plain radiographs showed a non-union of the tibia fracture, and microbiological analysis confirmed a wound infection with cefuroxime-sensitive Staphylococcus aureus. " 04/01/2001 - "These preliminary results of continuous infusion of cefuroxime 3 g/d for prophylaxis of sternal wound infections in CABG patients indicate that serum concentrations are highly variable, but reliably above the minimum inhibitory concentration for the common anticipated pathogens in this setting. " 01/01/1996 - "Cefuroxime is a second-generation cephalosporin with in vitro activity against the organisms that are commonly associated with neurosurgical wound infections. " 12/01/1994 - "It is concluded that in coronary artery bypass grafting a single dose of cefuroxime is as effective as a three-day course in the prevention of wound infection."

Related Drugs and Biologics

1.	Ceftriaxone (Ceftriaxon)
2.	Metronidazole (Metric)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Amoxicillin (Wymox)
5.	cefuroxime axetil (Ceftin)
6.	Gentamicins (Gentamicin)
7.	Ampicillin (Omnipen)
8.	Cefotaxime (Kendrick)
9.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)
10.	Ciprofloxacin (Cipro)

Related Therapies and Procedures

1.	Arthroplasty
2.	Antibiotic Prophylaxis
3.	Drug Therapy (Chemotherapy)
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Vaginal Hysterectomy