Gentamicins (Gentamicin)

A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (GENETIC TRANSLATION).

Also Known As:

Networked: 5166 relevant articles (586 outcomes, 669 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Steyger, Peter S: 11 articles (11/2015 - 10/2007)
2.	Carey, John P: 8 articles (04/2015 - 02/2004)
3.	Stojiljkovic, Nenad: 7 articles (04/2012 - 06/2008)
4.	Silverstein, Herbert: 7 articles (04/2010 - 06/2002)
5.	Minor, Lloyd B: 7 articles (08/2009 - 05/2003)
6.	Heinrich, Ulf-Rüdiger: 6 articles (08/2015 - 01/2006)
7.	Gamazo, Carlos: 6 articles (07/2013 - 06/2004)
8.	Stoiljkovic, Milan: 6 articles (04/2012 - 06/2008)
9.	Mann, Wolf J: 6 articles (12/2011 - 11/2005)
10.	López-Novoa, José M: 6 articles (02/2011 - 12/2002)

Related Diseases

1.	Infection 01/01/2015 - "Gentamicin is an aminoglycoside antibiotic that is highly effective in treating Gram-negative infections, but inappropriate use leads to toxicity. " 03/01/2012 - "Regional intravenous gentamicin administration was very effective in treating distal extremity infection." 04/11/2006 - "Gentamicin is an aminoglycoside antibiotic that is very effective in treating different gram negative infections, however, one of its main side effects is nephrotoxicity. " 01/01/1977 - "Daily dosages of up to 240 mg (3X80 mg) gentamicin are only effective in infections caused by very susceptible bacteria with a MIC up to 1 microgram/ml." 02/01/1975 - "Gentamicin is in general very effective against these infections. "
2.	Endocarditis 02/01/1985 - "The in vitro activity of gentamicin was compared with its therapeutic efficacy in rabbits with Streptococcus faecalis endocarditis. " 11/01/2003 - "This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. " 10/12/2013 - "Gentamicin once-daily in enterococcal endocarditis." 09/01/2013 - "faecalis infective endocarditis continues to be a very serious disease with considerable percentages of high-level gentamicin resistant strains and in-hospital mortality around 20%. " 04/30/2013 - "Our present pilot study suggests that the recommended 2-week treatment with gentamicin seems adequate and preferable in treating non-high-level aminoglycoside-resistant E faecalis infective endocarditis. "
3.	Vertigo (Positional Vertigo) 11/01/2001 - "Results of this study on this group of patients indicate that vertigo can be controlled in the long term using microdose gentamicin without a significant reduction in cochlear or vestibular function in most of the patients in our series. " 06/01/2010 - "The shunt group showed a significantly higher percentage of the best outcome (62%) than the gentamicin group (56%, p <or= 0.003), as well as a higher rate of complete vertigo control (86% versus 71%; p <or= 0.001). " 12/01/2008 - "Although low dose intratympanal gentamicin has empirically been very effective in treating Menière's disease, the mechanisms of elimination or amelioration of vertigo are still insufficiently understood. " 10/01/2003 - "Intratympanic gentamicin titration therapy provides excellent vertigo control, with a similarly significant improvement in both personal and occupational functioning." 01/01/2011 - "Both of these trials found a significant reduction in vertigo complaints in the gentamicin group when compared to the placebo group. "
4.	Sepsis (Septicemia) 09/01/2005 - "Because gentamicin improved hemodynamic variables and reduced the fluid requirement in this ovine model, we believe that this modified sepsis model might provide a clinically relevant and useful new approach for future studies focusing on hemodynamic variables and outcome." 06/01/1997 - "The protocol proved simple and effective with a low incidence of gentamicin-associated nephrotoxicity (7%) and no sepsis-related deaths." 05/01/2014 - "Gentamicin concentrations and clinical data including the Reported Edmonton Frail Scale score were pooled from two prospective observational inpatient studies, one on prophylactic gentamicin for urologic surgery and one on therapeutic gentamicin for the empiric treatment of sepsis. " 10/01/2009 - "The study was conducted to evaluate the pharmacokinetics of gentamicin for the treatment of neonatal sepsis in predetermined doses at 24- or 48-hour intervals, according to weight category, and to develop a simplified protocol for use in peripheral healthcare settings in developing countries. " 06/01/2007 - "The purpose of this study was to determine safe, effective, simplified dosing regimens of gentamicin for treatment of neonatal sepsis in developing countries. "
5.	Wounds and Injuries (Trauma) 01/01/2015 - "Topical delivery of ultrahigh concentrations of gentamicin is highly effective in reducing bacterial levels in infected porcine full-thickness wounds." 09/01/2010 - "Thus, this gentamicin-loaded wound dressing would be used as a potential wound dressing with excellent forming and improved healing effect in wound care." 06/01/2009 - "The released gentamicin also resulted in a significant decrease in bacterial viability and practically no bacteria survived after 2 days when using bacterial concentrations of 1 x 10(7) CFU/mL. Thus, our new fiber structures are effective against the relevant bacterial strains and can be used as basic elements of bioresorbable drug-eluting wound dressings." 12/01/2012 - "The aim of the study was to assess the efficacy of complementary application of a gentamicin-impregnated sponge in the perineal wound or in the vicinity of intestinal anastomosis after abdominoperineal resection or low anterior resection. " 10/01/2014 - "Gentamicin conditioning confers auditory protection against noise trauma."

Related Drugs and Biologics

1.	Clindamycin (Cleocin)
2.	Ampicillin (Omnipen)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Vancomycin
5.	Tobramycin (Nebcin)
6.	Metronidazole (Metric)
7.	Amikacin (A.M.K)
8.	Ciprofloxacin (Cipro)
9.	Penicillins (Penicillin)
10.	Ceftriaxone (Ceftriaxon)

Related Therapies and Procedures

1.	Injections
2.	Catheters
3.	Renal Dialysis (Hemodialysis)
4.	Peritoneal Dialysis
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)