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Metronidazole (Metric)

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A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

Also Known As:

Metric; Satric; Flagyl; MetroGel; Clont; 2-Methyl-5-nitroimidazole-1-ethanol; Bayer 5360; Danizol; Gineflavir; Metrodzhil; Metrogyl; Metronidazole Hydrochloride; Metronidazole Monohydrochloride; Metronidazole Phosphate; Metronidazole Phosphoester; Trichazol; Trichopol; Trivazol; Vagilen; 2 Methyl 5 nitroimidazole 1 ethanol; Hydrochloride, Metronidazole; Monohydrochloride, Metronidazole; Phosphate, Metronidazole; Phosphoester, Metronidazole; 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-

Networked: 4448 relevant articles (643 outcomes, 710 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Feres, Magda: 11 articles (09/2014 - 10/2008)
2.	Faveri, Marcelo: 10 articles (09/2014 - 10/2008)
3.	Del Rosso, James Q: 8 articles (12/2014 - 01/2004)
4.	Figueiredo, Luciene Cristina: 8 articles (09/2014 - 10/2008)
5.	Socransky, Sigmund S: 8 articles (04/2014 - 09/2006)
6.	Schwebke, Jane R: 7 articles (07/2015 - 01/2002)
7.	Sobel, Jack D: 7 articles (07/2015 - 05/2006)
8.	Azam, Amir: 7 articles (08/2012 - 06/2005)
9.	Graham, D Y: 7 articles (01/2005 - 03/2000)
10.	Lam, S K: 7 articles (03/2003 - 02/2000)

Related Diseases

1.	Infection 01/01/1983 - "Studies carried out at the Luton and Dunstable Hospital, and subsequently at other centers, have shown that metronidazole, a specifically anaerobicidal agent without significant activity against aerobic organisms, is highly effective in preventing postoperative morbidity resulting from anaerobic infections. " 08/01/2012 - "However compound 13a showed most promising results with IC(50) = 0.86 μM which is half of the metronidazole, the standard drug used for protozoal infection. " 09/01/2001 - "Antibiotic treatment can be highly effective for Shigella, ETEC, and V. cholerae infections, and metronidazole is indicated for C. " 07/01/1990 - "A single 2-g oral dose of metronidazole still remains highly effective against most Trichomonas vaginalis infections. " 12/01/1974 - "The pharmacokinetics of metronidazole, a drug effective in vitro against most anaerobic bacteria and promising in treating anaerobic infections, are described. "
2.	Bacterial Vaginosis 07/01/2000 - "Most patients with odor had bacterial vaginosis and had an improvement in odor with topical metronidazole. " 04/01/1999 - "The most cost-effective treatment for bacterial vaginosis was generic metronidazole. " 07/01/1990 - "Metronidazole (500 mg twice daily for 7 days) continues to be highly efficacious in the treatment of bacterial vaginosis. " 12/01/2008 - "Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects." 03/10/1991 - "Mobiluncus associated bacterial vaginosis can be treated successfully with 500 mg of metronidazole three times a day for seven days."
3.	Rosacea (Acne Rosacea) 08/01/2007 - "The remarkable clinical efficacy of metronidazole in the treatment of rosacea is probably due to its ability to decrease ROS via different mechanisms, thereby protecting skin components from induced damage." 05/01/2000 - "Topical metronidazole formulations are significantly more effective than placebo when used in the initial treatment of patients with moderate to severe rosacea. " 05/01/2000 - "Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than placebo in patients with moderate to severe rosacea when administered to the affected area once or twice daily for 7 to 12 weeks. " 01/01/2012 - "In conclusion, the microemulsion containing metronidazole was found to be more effective in reducing the symptoms of rosacea compared to the commercial gel product." 11/01/2001 - "The papules and pustules of rosacea can be effectively treated with topical metronidazole. "
4.	Crohn Disease (Crohn's Disease) 09/04/1981 - "Clinical remission was achieved in all ten patients with highly florid Crohn's disease but no fistulae, regardless of whether metronidazole was given alone or in combination with the basic treatment regimen. " 03/19/1994 - "Metronidazole has been proven quite effective in patients with Crohn's disease of the colon, particularly in the perianal region.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1984 - "Correlation analysis, although limited by the small number of patients investigated so far, indicated a possible positive correlation between metronidazole serum concentrations and disease activity (CDAI, r = 0.480) and therapeutic efficacy (delta CDAI, r = 0.430) in Crohn's disease." 01/01/1984 - "Serum concentrations of metronidazole and its main metabolite in patients with active Crohn's disease: correlation with disease activity and therapeutic efficacy?" 05/01/1983 - "Metronidazole, an antimicrobial agent that is effective against anaerobes, has recently been shown useful in Crohn's disease involving the colon and perianal area. "
5.	Giardiasis 01/01/2010 - "In spite of its therapeutic efficacy for giardiasis, low patient compliance, especially in children, side effects, and the emergence of metronidazole-resistant strains may restrict its use. " 01/01/2006 - "boulardii may be effective in treating giardiasis when combined with metronidazole therapy." 10/01/1987 - "Therefore, metronidazole appears to be an effective form of therapy for feline giardiasis." 01/01/2014 - "Therefore, when testing new potential antigiardial drugs, O2 should be taken into account, since it also reduces the efficacy of metronidazole, the gold standard drug against giardiasis. " 01/01/2015 - "It is urgent to develop novel drugs to treat giardiasis, due to increasing clinical resistance to the gold standard drug metronidazole (MTZ). "

Related Drugs and Biologics

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2.	Ciprofloxacin (Cipro)
3.	Clindamycin (Cleocin)
4.	Clarithromycin (Biaxin)
5.	Tetracycline (Achromycin)
6.	Gentamicins (Gentamicin)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Omeprazole (Esomeprazole)
9.	Vancomycin
10.	Tinidazole

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Hysterectomy
3.	Enema (Enemas)
4.	Root Planing
5.	Cesarean Section (Caesarean Section)