beta Lactam Antibiotics

Bactericidal agents that contain a beta-lactam ring in their chemical structure. They inhibit bacterial cell wall synthesis by binding to PENICILLIN-BINDING PROTEINS, preventing the synthesis of peptidoglycan in bacterial cell walls.

Also Known As:

Networked: 1054 relevant articles (53 outcomes, 79 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roberts, Jason A: 11 articles (12/2020 - 07/2007)
2.	Lipman, Jeffrey: 10 articles (10/2016 - 07/2007)
3.	Dou, Q Ping: 5 articles (09/2008 - 06/2002)
4.	Turos, Edward: 5 articles (09/2008 - 06/2002)
5.	Barberán, J: 4 articles (02/2022 - 12/2000)
6.	Abdul-Aziz, Mohd H: 4 articles (12/2020 - 08/2012)
7.	Falagas, Matthew E: 4 articles (10/2020 - 04/2005)
8.	Demoly, Pascal: 4 articles (01/2020 - 01/2008)
9.	Torres, M J: 4 articles (02/2016 - 05/2003)
10.	Paterson, David L: 4 articles (09/2013 - 01/2004)

Related Diseases

1.	Infections 05/01/1997 - "As a group, they remain effective against infections caused by aerobic gram-negative organisms and Staphylococcus aureus, including species commonly resistant to beta-lactam antibiotics. " 12/01/2020 - "The emergence of novel resistant markers hampers the efficacy of beta-lactam antibiotics to treat infections caused by micro-organisms carrying such resistances. " 06/10/2021 - "This is due to the loss of efficacy of beta-lactam antibiotics, which are used as the first treatment option in the management of infections caused by Gram-negative bacteria. " 11/01/2023 - "The aim of this study was to compare the achievement of therapeutic pharmacokinetic-pharmacodynamic (PK-PD) exposure targets for beta-lactam antibiotics using product information dosing or guideline-based dosing for the treatment of serious infections. " 09/01/2023 - "Clinical efficacy and safety of prolonged versus intermittent administration of antipseudomonal beta-lactam antibiotics in adults with severe acute infections: A meta-analysis of randomized controlled trials."
2.	Hypersensitivity (Allergy) 01/01/2022 - "Management of Beta-Lactam Antibiotics Allergy: A Real-Life Study." 11/01/2016 - "Hypersensitivity to beta-lactam antibiotics: a three-year study." 07/01/2007 - "This study demonstrates that the prevalence of allergic reactions to beta-lactam antibiotics is high in adults with CF. " 07/01/2007 - "The aim of this study was to assess the prevalence of allergy to anti-pseudomonal beta-lactam antibiotics in an adult CF centre and to assess variables, which may contribute to the development of allergic reactions. " 01/01/1996 - "Booster responses in the study of allergic reactions to beta-lactam antibiotics."
3.	Sepsis (Septicemia) 10/29/2022 - "Continuous infusion of beta-lactam antibiotics has emerged as an alternative for the treatment of sepsis because of the favourable pharmacokinetics of continuous infusion. " 01/01/2022 - "We conducted a literature scoping review to identify therapeutic targets of beta-lactam antibiotics in septic pediatric patients and the strategies that have been applied to overcome sepsis-related altered pharmacokinetics and increase target attainment against susceptible pathogens. " 10/01/2020 - "Benefits of prolonged infusion of beta-lactam antibiotics in patients with sepsis: personal perspectives." 09/01/2018 - "Since certain beta lactam antibiotics may induce bacteriolysis, it is questioned whether these may aggravate sepsis patient's condition. " 11/01/2016 - "[Continuous infusion of beta-lactam antibiotics in severe sepsis (BLISS)]."
4.	Critical Illness (Critically Ill) 01/01/2022 - "Health Care Costs of Target Attainment for Beta-Lactam Antibiotics in Critically Ill Patients: A Retrospective Analysis of the EXPAT Study." 12/03/2023 - "[Therapeutic drug monitoring of beta-lactam antibiotics in critically ill adult patients.]" 05/01/2023 - "Continuous infusion (CI) of beta-lactam-antibiotics may improve pharmacodynamics in critically ill patients, but resulting concentrations have not been studied. " 03/13/2023 - "Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients-A Narrative Review." 11/14/2022 - "Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address the variability in exposure observed in critical illness. "
5.	Pneumonia (Pneumonitis) 01/29/2016 - "Beta-lactam antibiotics form the backbone of treatment for Gram-negative pneumonia in mechanically ventilated patients in the intensive care unit. " 01/01/2015 - "These conditions were regarded as signs of pneumonia that required the application of increasingly more powerful beta-lactam antibiotics. " 02/01/2004 - "This is the same as what was observed before except eleven out of the 13 of the mixed pneumonia patients responded to treatment with only beta-lactam antibiotics. " 12/01/2003 - "CAM (200 mg given twice daily for 2 weeks) was orally administered to 26 patients with mild or moderate suspected atypical pneumonia, including 15 patients in whom treatment with beta-lactam antibiotics was largely ineffective. " 08/01/2000 - "Beta-lactam antibiotics are usually not the first choice for empiric outpatient treatment of community-acquired pneumonia. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Vancomycin
3.	Aminoglycosides
4.	Penicillins (Penicillin)
5.	Macrolides
6.	beta-Lactamases (beta-Lactamase)
7.	Ampicillin (Omnipen)
8.	Amoxicillin (Wymox)
9.	Aztreonam
10.	Third Generation Cephalosporins

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Aftercare (After-Treatment)
4.	Cardiopulmonary Resuscitation (CPR)
5.	Renal Replacement Therapy (Therapies, Renal Replacement)