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Ampicillin (Omnipen)

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

Also Known As:

Omnipen; Polycillin; Amcill; Aminobenzylpenicillin; Ampicillin Sodium; Ampicillin Trihydrate; KS-R1; Pentrexyl; Ukapen; Aminobenzyl Penicillin; KS R1; KSR1; Sodium, Ampicillin; Trihydrate, Ampicillin; Penicillin, Aminobenzyl; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-

Networked: 3311 relevant articles (354 outcomes, 336 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kohno, Shigeru: 8 articles (03/2015 - 01/2006)
2.	Sunakawa, Keisuke: 8 articles (08/2013 - 05/2004)
3.	Ubukata, Kimiko: 8 articles (08/2013 - 05/2004)
4.	Yasui, Wataru: 6 articles (08/2014 - 07/2010)
5.	Sentani, Kazuhiro: 6 articles (08/2014 - 07/2010)
6.	Oue, Naohide: 6 articles (08/2014 - 07/2010)
7.	Sakamoto, Naoya: 6 articles (08/2014 - 07/2010)
8.	Hayashi, Tetsutaro: 5 articles (08/2014 - 07/2010)
9.	Czeizel, Andrew E: 5 articles (01/2014 - 01/2007)
10.	Yanagihara, Katsunori: 5 articles (12/2013 - 01/2006)

Related Diseases

1.	Infection 07/01/1981 - "Ampicillin given at the time of maximum bacterial growth at 24 hr caused a striking reduction in the number of protective T cells produced at the time of peak response on day 6. Although the greatest effect was caused by giving ampicillin early in infection, a significant reduction in peak T cell production occurred even when Ampicillin was given as late as day 5. On the other hand, the effect of abridging infection at the onset of decay of the anti-Listeria response was to cause protective T cells to be lost from the spleen at a much faster rate. " 08/15/1998 - "Listeria monocytogenes infections in pediatric oncology patients can be treated successfully with ampicillin-containing antibiotic regimens." 05/01/1994 - "Single intra-abdominal administration of sodium ampicillin during surgery provides good protection against infection without negative effects on the postoperative performance." 10/01/1987 - "Because high concentrations of ampicillin accumulated in the urine and bile, the antibiotic probably would have therapeutic efficacy for urinary and intestinal infections. " 04/01/1997 - "From the data, treatment with ampicillin is recommended, with resort to surgery in cases where the infection cannot be eradicated or where haemodynamic compromise has occurred."
2.	Endocarditis 01/01/1984 - "Ampicillin is effective in endocarditis due to Haemophilus influenzae, H. " 09/01/1990 - "Endocarditis due to ampicillin-resistant nontyphoid Salmonella: cure with a third-generation cephalosporin." 06/01/2013 - "Ampicillin (parenteral): prevention of infective endocarditis." 05/01/2007 - "After one month of intravenous ampicillin the aortic valve was replaced after being destroyed by endocarditis. " 07/01/2006 - "A diagnosis of infective endocarditis caused by the Erysipelothnx rhusiopatniae was made, and the patient was treated with aminobenzyl penicillin 12g/day for 6 weeks. "
3.	Pneumonia (Pneumonitis) 05/01/2014 - "Ampicillin treatment cured mice with mild pneumonia but was ineffective against severely pneumonic mice, despite effective bacterial killing. " 01/01/1992 - "The compound was found to be effective against the pneumonia in combination with subcutaneous ampicillin (ABPC). " 09/01/1993 - "A prospective study was conducted to evaluate the efficacy of ampicillin as an initial therapy in 60 adult patients with community acquired pneumonia. " 12/09/1972 - "A controlled trial was carried out to investigate whether the rate of recovery from pneumonia treated with ampicillin is dose related. " 02/01/2015 - "In all of the patients with pneumonia caused by Klebsiella species, there was resistance to ampicillin (P < 0.0001). "
4.	Meningitis 01/01/1991 - "We have demonstrated that the serum and cerebrospinal fluid concentrations of ampicillin and its efficacy when used in the treatment of meningitis are comparable whether they are administered intravenously or intramuscularly. " 08/01/1979 - "By comparison, 7 of 10 children with meningitis responded optimally to ampicillin (nonrandomized design) during the period of study. " 12/01/1964 - "INFLUENZAE MENINGITIS: A CONTROLLED STUDY OF TREATMENT WITH AMPICILLIN." 01/01/2011 - "She was diagnosed with purulent meningitis caused by actinomyces, and treated with intravenous ampicillin 12 g/day. " 06/01/2007 - "Streptococcus agalactiae is a rare cause of neonatal meningitis in the era of peripartum prophylaxis with prophylaxis with ampicillin in colonized/infected mothers. "
5.	Sepsis (Septicemia) 01/01/1989 - "CTX is indicated in the treatment of neonatal sepsis because of the increasing resistance of Escherichia coli to ampicillin and its good efficacy against group B streptococcus." 09/01/1985 - "A case of successful therapy with ampicillin of maternal septicemia due to Listeria monocytogenes at 26 weeks' gestation with resultant delivery at term of a normal neonate is reported. " 06/01/2013 - "Sepsis caused by group B streptococcus has been well controlled with aminobenzylpenicillin, but the incidence of Escherichia coli sepsis has increased in proportion. " 03/01/2013 - "A combination of ampicillin and aminoglycoside for early-onset neonatal sepsis." 03/01/2012 - "Antepartum and intrapartum antibiotic exposure was associated with ampicillin-resistant E coli sepsis (100% vs. 43%, p < 0.01). "

Related Drugs and Biologics

1.	Sulbactam
2.	Gentamicins (Gentamicin)
3.	Chloramphenicol (Chloromycetin)
4.	beta-Lactamases (beta-Lactamase)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
7.	Ceftriaxone (Ceftriaxon)
8.	Amoxicillin (Wymox)
9.	Penicillins (Penicillin)
10.	Vancomycin

Related Therapies and Procedures

1.	Catheters
2.	Hysterectomy
3.	Cesarean Section (Caesarean Section)
4.	Chemoprevention
5.	Drug Therapy (Chemotherapy)