Critical Illness (Critically Ill)

01/01/2013 - "Among those few admitted for clinical intervention, intensive insulin treatment has proven to be effective in the reduction of disease related complications in critically ill patients. "
01/01/2022 - "In the subgroup of patients undergoing hyperglycemic clamps, insulin sensitivities improved similarly and significantly from acute and protracted critical illness to 6 months after discharge. "
02/01/2009 - "The initial high values of serum insulin and IR were significantly reduced (p < 0.05) as these patients recovered from their critical illness. "
07/01/2014 - "In non-critically ill type 2 diabetic patients the basal bolus regimen is superior to sliding and pre-mixed insulin regimen. "
08/01/2005 - "Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?"

01/01/1991 - "Our study established distinct advantages of percutaneous drainage under computerized tomographic and ultrasonic guidance: (1) the procedures can be carried out under ultrasonic guidance in an intensive care unit on critically ill patients, (2) the technique proved highly effective for initial palliation, with defervescence and stabilization occurring in most critically ill patients within 48 hours, (3) findings from fine needle aspiration provided valuable information as to microorganisms and antibiotic sensitivities and differed in 29 of 85 patients from those of concomitant blood cultures, and (4) definitive eradication of the process (surgical ablation of residual necrotic material) can be elected after the patient's clinical condition stabilizes."
09/01/2015 - "Administration of highly bioavailable oral antibiotics should be considered for nearly all non-critically ill patients and has been recommended as an effective and safe strategy for over two decades. "
01/01/2014 - "An augmented renal clearance has been described in some groups of critically ill patients, and it might induce sub-optimal concentrations of drugs eliminated by glomerular filtration, mainly antibiotics. "
02/01/2013 - "In spite of controversy the continuous administration of this group of antibiotics is common practice, because the results of both studies point to the higher efficacy of this method in critically ill patients. "
12/01/2000 - "Applying pharmacokinetic and pharmacodynamic principles to critically ill patients will lead to better antibiotic use and hopefully a better outcome."

08/01/2017 - "Optimal protein nutrition, optimal exercise intervention as well as the optimal combination of nutrition, and exercise may help to improve long-term physical performance outcome in the critically ill patients."
01/01/2023 - "Our study revealed that the VBF protocol significantly improved calorie and protein delivery in critically ill patients with no additional risk."
11/13/2021 - "This study showed that a high-protein intake and resistance exercise improved the physical quality of life and survival of critically ill patients. "
04/01/2017 - "Over a dozen observational studies in critically ill patients suggest that higher protein delivery is beneficial at protecting muscle mass and associated with improved outcomes (decrease in mortality). "
11/01/2022 - "In unselected critically ill patients, clinical outcome may not be improved by a high protein intake during the acute phase. "

03/06/2014 - "Thereafter, accuracy of the device to measure plasma glucose levels in 'our cohort' of critically ill patients improved, but external validation is highly recommended. "
01/01/2017 - "Continuous glucose monitoring (CGM) can be beneficial in critically ill patients. "
09/01/2010 - "Even without diabetes, tight glucose control is beneficial in hospitalized, critically ill patients. "
03/01/2005 - "Implementing a computerized version of a guideline significantly improved timeliness of measurements and glucose level regulation for critically ill patients compared with implementing a paper-based version of the guideline."
09/19/2022 - "We hypothesize that tight glucose control is effective and safe using a validated protocol in adult critically ill patients not receiving early PN. "

06/01/2018 - "maxima may decrease high blood glucose level fast and effective in diabetic critically ill patients."
01/01/2009 - "Maintaining arterial blood glucose within tight limits is beneficial in critically ill patients. "
09/01/2008 - "Controlling blood glucose concentrations may therefore be beneficial in the critically ill neonatal foal, and this warrants further investigation."
02/15/2022 - "The purpose of this study is to determine the safety and efficacy of an IIP targeting a blood glucose of 140 to 180 mg/dL in critically ill patients, with the ultimate goal of validating such a protocol. "
12/01/2022 - "Conclusion: Critically ill non-diabetic patients who spent at least 40% of time in blood glucose range of 70-120 mg/dL had improved survival. "

01/01/2018 - "Serial biomarker monitoring may be associated with improved patient outcomes in the most critically ill septic patients."
01/01/2022 - "In critically ill patients with CHF, ones with high coagulation disorder score tend to be worse clinical prognosis, which would be a promising biomarker and helpful for the management of CHF patients."
01/01/2020 - "Patients critically ill with coronavirus disease-2019 (COVID-19) feature hyperinflammation, and the associated biomarkers may be beneficial for risk stratification. "
10/01/2013 - "Clinical models for triage of critical illness could be significantly improved by incorporating biomarkers, yet substantial sample sizes and biomarker strength may be required."
05/01/2011 - "PCT represents a good biological marker for difficult diagnoses in critically ill patients and is superior to CRP. "

02/01/2016 - "Most clinicians agree that oxygen titration should be done and, with appropriate safeguards, lower oxygenation targets may be acceptable and possibly beneficial in many critically ill patients. "
07/01/1993 - "When serial measurements of oxygen delivery, oxygen consumption, and the oxygen extraction ratio follow each therapeutic intervention that is directed at increasing oxygen delivery, the survival rate of critically ill patients is significantly improved."
01/01/2015 - "This paper presents results for applying the approach to the hemodynamic monitoring of infants immediately following cardiac surgery and demonstrates its efficacy of estimating the probability of inadequate systemic oxygen delivery, which is an essential risk attribute in the management of critically ill patients."
05/01/2012 - "SvO(2) monitoring, it could be argued, provides the gold standard for assessing arterial and venous oxygen indices in the critically ill. "
01/01/2011 - "Physicians often justify RBC transfusions in critically ill children when anaemia is present because of the assumption that by increasing the haemoglobin level the delivery of oxygen (DO2) to peripheral tissues is improved so that ultimately the oxygen utilization (VO2) can be improved. "

01/01/2014 - "We found corticosteroids to be beneficial in the whole population (non-critically ill and critically ill patients) in terms of treatment success rate. "
07/01/2013 - "The efficacy of systemic corticosteroids in many critical illnesses remains uncertain. "
01/01/2020 - "Our study concludes that more severe and critically ill patients tend to get corticosteroids, and the mortality risk increases with the use of corticosteroids. "
01/01/2020 - "Future studies on corticosteroid-treatment in critically ill children should plan safety analyses, as harm may be possible."
11/01/2019 - "We systematically reviewed randomised clinical trials comparing systemic corticosteroids administered for more than 24 h with placebo/no treatment in adult critically ill patients. "

12/01/2010 - "Although the pharmacodynamic parameters that better predict the efficacy of colistin are not known in humans, in critically ill adult patients the IV administration of CMS 2 million International Units (174 mg) q8h results in apparently suboptimal plasma concentrations of colistin, which is undetectable in BAL. "
01/01/2023 - "This study compared microbiologic cure with colistin SFDR to WBD in critically ill adults. "
12/01/2017 - "The aim of this study was to assess the safety and efficacy of colistin use in critically ill neonates. "
10/01/2019 - "A Randomized Clinical Trial Evaluating the Efficacy of Colistin Loading Dose in Critically Ill Children."
01/01/2019 - "Adjunctive AS colistin in combination with IV colistin with LD was related to an improved 30-day mortality and microbiological outcome without an increase in nephrotoxicity in critically ill patients with HAP and VAP caused by CRGNB. "

01/01/2001 - "Although glutamine status in the critically ill patient can be improved by nutritional means, the most effective way of effecting such supplementation has received little attention. "
11/01/2011 - "However, given the good results and absence of glutamine-related adverse effects in the various studies performed in the general population of critically-ill patients, these patients could benefit from the use of this substance. "
11/01/2011 - "However, given the good results and absence of glutamine-related adverse effects in the various studies performed in the general population of critically-ill patients, these patients could benefit from the use of this substance. "
11/01/1996 - "We hypothesize that glutamine-enriched TPN may have been beneficial in the hospital course of this critically ill patient and may have influenced the patient's intestinal function and permeability."
11/15/2023 - "The efficacy of supplemental enteral glutamine (GLN) in critical illness patients remains uncertainty. "

07/13/2023 - "Extracorporeal liver-support therapies remain controversial in critically ill patients, as most studies have failed to show an improvement in outcomes. "
01/01/2021 - "The network meta-analysis provides evidence that amongst the five therapies, synbiotics not only prevented NI in critically ill adults but also demonstrated the best treatment results. "
01/01/2021 - "Conclusions: Amongst the five therapies, synbiotics not only prevented NI in critically ill adults but also demonstrated the best treatment results. "
07/01/2018 - "Enteral nutritional therapy (ENT) is the best route for the nutrition of critically ill patients with improved impact on the clinical treatment of such patients. "
12/01/2015 - "Over the past decades, survival of critically ill hematological patients has dramatically improved, and these patients are more frequently referred to the ICU for intensive treatment, including a rising need for administering anticancer-therapy in this setting. "

01/01/2023 - "Advances in pediatric intensive care have dramatically improved the prognosis for critically ill patients. "
01/01/2006 - "Appropriate positioning of the critically ill patient can dramatically improve gas exchange, resulting in a shorter stay in the critical care unit and an improved outcome. "
01/01/1988 - "Long-term Swan-Ganz monitoring in an intensive care setting may dramatically benefit the critically ill patient with GBS and cardiovascular autonomic dysfunction, and may help to eliminate the residual morbidity and mortality associated with this disease."
12/01/2022 - "This article illustrates the ways in which critically ill patients with HF have helped to shape contemporary CICUs throughout the world and explores how these very patients will similarly help to inform the future maturation of these specialized critical care units. "
01/01/2022 - "Advances in pediatric intensive care have led to markedly improved survival rates in critically ill children. "

01/01/2019 - "In critical illness, enteral nutrition is recommended and has theoretical (but not proven) advantages towards improved inner microbial health and diminution of bacterial translocation. "
04/01/2014 - "Randomized trials suggest that early enteral nutrition is beneficial in critically ill adults. "
01/01/2020 - "The implementation of the enteral feeding protocol is associated with improved energy intake and a decreased incidence of enteral nutrition related adverse events for critically ill patients, but it had no statistically beneficial effects on reducing the hospital mortality rate. "
08/01/1995 - "Furthermore, there is increasing evidence, that enteral nutrition provides significant benefits to patients who are critically ill and after major gastrointestinal surgery. "
01/06/2023 - "Additional randomized trials with better methodology are needed to assess the efficacy of the two enteral feeding regimens in critically ill PICU patients."

08/01/2007 - "We evaluated the efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation. "
08/01/2007 - "The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation."
09/18/2023 - "Medication regimen complexity is significantly associated with prolonged duration of mechanical ventilation in critically ill patients, and prediction models incorporating medication information showed modest improvement in this prediction."
06/19/2023 - "The use of ILE for days 4 to 7 in PN prescribed for critically ill patients, who were in an ICU receiving mechanical ventilation and fasting for more than 7 days, was associated with a significant reduction in in-hospital mortality."
01/01/2019 - "A 3-day pilot curriculum demonstrated significant improvement in the confidence (in person P<0.001; telementoring P=0.001), knowledge (in person P<0.001; telementoring P=0.022) and performance (in person P<0.001; telementoring P<0.002) of medical students in their ability to manage a critically ill patient on mechanical ventilation. "

01/01/2021 - "Continuous renal replacement therapy (CRRT) has significant benefits in the treatment of critically ill children. "
01/01/1990 - "CVVHD is an effective treatment of choice applicable to all critically ill unstable patients with CARF. "
01/01/2021 - "The aim of this study was to explore the feasibility and efficacy of the modified protocol for continuous veno-venous hemofiltration (CVVH) in unselected critically ill patients. "
01/01/2022 - "To evaluate the efficacy of risk management in the nursing of critically ill patients on continuous renal replacement therapy (CRRT). "
01/01/2018 - "Prognostic Factors and Efficacy for Continuous Renal Replacement Therapy in Critically Ill Patients: A Chinese Single-Center Retrospective Study."