Polyether Polyketides

Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.

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Networked: 22 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huczyński, Adam: 4 articles (07/2019 - 12/2012)
2.	Antoszczak, Michał: 3 articles (07/2019 - 01/2016)
3.	Steverding, Dietmar: 3 articles (07/2019 - 01/2016)
4.	Dembitsky, Valery M: 1 article (04/2022)
5.	Andersen, Frederikke D: 1 article (01/2021)
6.	Jacobsen, Kristian M: 1 article (01/2021)
7.	Lin, Shaoquan: 1 article (01/2021)
8.	Liu, Han: 1 article (01/2021)
9.	Moyano-Villameriel, Jaime: 1 article (01/2021)
10.	Nørby, Peter: 1 article (01/2021)

Related Diseases

1.	Parasitic Diseases (Parasitic Disease) 02/01/2009 - "Polyether ionophores show a high degree of promise for the potential control of drug-resistant bacterial and parasitic infections. " 03/15/2019 - "This review summarizes the anti-parasitic effects of the most important polyether ionophores against parasites that are responsible for a number of animal and human parasitic diseases. "
2.	Neoplasms (Cancer) 04/26/2022 - "Further study of the mechanisms of action and the search for new polyether ionophores and their derivatives may provide more effective therapeutic natural polyether ionophores for the treatment of cancer and other diseases. " 07/23/2022 - "Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management." 01/01/2021 - "Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. " 01/01/2016 - "Polyether ionophores have been shown to display anti-cancer, anti-microbial and anti-parasitic activity. " 12/01/2012 - "Increasing evidence shows that the anticancer activity of polyether ionophores may be a consequence of the induction of apoptosis leading to apoptotic cell death, arresting cell cycle progression, induction of the cell oxidative stress, loss of mitochondrial membrane potential, reversion of MDR, synergistic anticancer effect with other anticancer drugs, etc. Continued investigation of the mechanisms of action and development of new polyether ionophores and their derivatives may provide more effective therapeutic drugs for cancer treatments."
3.	Coccidiosis 08/30/2023 - "Polyether antibiotics (PAs) are the anti-coccidiosis drugs used for treating and preventing coccidiosis. " 05/01/2017 - "Polyether ionophores are widely used to treat and control coccidiosis in chickens. " 02/01/2020 - "Maduramicin is the most efficient and possesses the largest market share of all anti-coccidiosis polyether antibiotics (ionophore); however, its biosynthetic gene cluster (BGC) has yet to been identified, and the associated strains have not been genetically engineered. " 01/01/2022 - "Carboxylic ionophores, such as monensin, salinomycin and lasalocid, are polyether antibiotics used widely in production animals for the control of coccidiosis, as well as for the promotion of growth and feed efficiency. "
4.	Virus Diseases (Viral Diseases) 02/01/2009 - "This is the first article to report that polyether antibiotics can be effective on viral infection in vivo." 10/01/2007 - "Immunization against Angara disease virus (ADV), a serotype 4 avian adenovirus, and Newcastle disease virus (NDV), an avian paramyxovirus serotype 1, is the mainstay of a broiler vaccination programme, while polyether ionophores usually form an essential component of a broiler medication programme in most parts of India and Pakistan. "
5.	Poisoning 04/01/2010 - "[Status quo of research on veterinary polyether antibiotics poisoning]."

Related Drugs and Biologics

1.	Lasalocid
2.	Monensin (Coban)
3.	Ionophores
4.	salinomycin
5.	maduramicin
6.	narasin
7.	Peptides (Polypeptides)
8.	Nigericin
9.	alborixin

Related Therapies and Procedures

1.	Therapeutics