Septate Uterus

A congenital duplication of the UTERUS in which a septum is formed separating the uterus. The partitioning septum can also separate the CERVIX and VAGINA.

Also Known As:

Septate Uteri, Complete; Septate Uterus, Complete; Septate Uterus, Incomplete; Septum, Uterine; Uterine Septums; Uterus, Septate; Uterus, Subseptate; Complete Septate Uteri; Complete Septate Uterus; Incomplete Septate Uterus; Septate Uterus and Vagina; Subseptate Uteri; Subseptate Uterus; Uterine Septum

Networked: 112 relevant articles (5 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Female Urogenital Diseases
    - Female Genital Diseases: 393
      - Uterine Diseases: 433
        Uterine Duplication Anomalies: 21
        Septate Uterus: 112

Related Diseases

1.	Leiomyoma (Uterine Fibroids)
2.	Polyps
3.	Carcinoma (Carcinomatosis)
4.	Heterotopic Pregnancy
5.	Spontaneous Abortion (Miscarriage)

Experts

1.	Xu, Dabao: 2 articles (07/2022 - 11/2021)
2.	Zhao, Xingping: 2 articles (07/2022 - 11/2021)
3.	Angioni, Stefano: 2 articles (02/2020 - 11/2016)
4.	Fernandez, Hervé: 2 articles (01/2016 - 05/2003)
5.	Litta, Pietro: 2 articles (09/2007 - 04/2004)
6.	Yu, Yang: 1 article (07/2022)
7.	Zou, Lingxiao: 1 article (07/2022)
8.	Boyle, Phil C: 1 article (06/2022)
9.	Stanford, Joseph B: 1 article (06/2022)
10.	Zecevic, Ivana: 1 article (06/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Septate Uterus:

1.	Estrogens (Estrogen)FDA Link 06/01/2010 - "Neither IUD placement, nor estrogen treatment, nor both were found to prevent intrauterine adhesions or facilitate pregnancy after hysteroscopic uterine septum resection." 08/01/1996 - "To evaluate the influence of estrogen after hysteroscopic incision of the uterine septum. " 08/01/1996 - "Is estrogen necessary after hysteroscopic incision of the uterine septum?" 11/29/2023 - "Efficacy of intrauterine balloon stent or oral estrogen on prevention of adhesion after transcervical resection of septum in septate uterus: Study protocol for a randomized controlled multicenter study in China." 06/01/2010 - "Intrauterine device or estrogen treatment after hysteroscopic uterine septum resection."
2.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 03/01/1998 - "Sixty patients undergoing hysteroscopic metroplasty for septate uterus who were randomly allocated to pretreatment with two injections monthly of Gonadotropin-Releasing Hormone analogue or to no pretreatment. " 12/01/1987 - "Newer approaches include the hysteroscopic resection of the uterine septum and medical therapy with GnRH analogues for reduction of fibroid size, volume, and symptoms. " 01/01/1996 - "To compare the efficacy of danazol and a GnRH agonist as preoperative preparation for hysteroscopic metroplasty in women with septate uterus. "
3.	SiliconesIBA 11/01/2015 - "Safe and Effective Surgery for Septate Uterus: 21 Cases Treated By Hysteroscopic Metroplasty With Hysterography and Custom-Made Intra-Uterine Silicone Plate."
4.	Danazol (Azol)FDA LinkGeneric 01/01/1996 - "To compare the efficacy of danazol and a GnRH agonist as preoperative preparation for hysteroscopic metroplasty in women with septate uterus. "
5.	SolutionsIBA 01/02/2021 - "Based on evidence from retrospective observational studies, hysteroscopic incision has been considered a solution to improve reproductive performance, however there has been recent controversy on the need for surgery for uterine septum. "
6.	auto-cross-linked polysaccharideIBA 11/01/2022 - "The present study showed that the use of ACP gel appeared to reduce both the tendency of IUA and American Fertility Society (AFS) scores and improve the subsequent pregnancy rate during hysteroscopic electrosurgical resection when treating polyps, fibroids, and uterine septum. "
7.	Diethylstilbestrol (Stilbestrol)FDA Link 05/01/1991 - "We report a case of a twin pregnancy at term obtained after five multiple embryo transfers in a patient who presented diethylstilbestrol (DES)-associated cervical and uterine structural abnormalities, a septate uterus and bilateral tuberculous salpingitis. " 05/01/1991 - "Diethylstilbestrol-induced müllerian abnormalities, septate uterus, genital tuberculosis and twin pregnancy with term delivery after in-vitro fertilization." 03/01/2020 - "The American Fertility Society, European Society of Human Reproduction and Embryology, and the European Society of Gynaecological Endoscopy classify malformations as: Class 1/U5bC4V4: agenesis or hypoplasia of uterus and vagina; Class 1/U5aC4V4: cervical hypoplasia, associated with total or partial vaginal agenesis; Class 2/U4: unicornuate uterus; Class 3/U3bC2V1 or Class3/U3bC2V2: uterus didelphys; Class 4/U3C0: bicornuate uterus; Class 5/U2: septate uterus; Class 6: arcuate uterus; Class 7/U1: induced by diethylstilbestrol, represented by a T-shaped uterus; and V3: transverse vaginal septum. " 05/01/2010 - "Using 3D ultrasound we diagnosed: one case with uterine agenesis; 10 with unicornuate uterus, four of which also underwent MRI; six with didelphic uterus, one of which had MRI; 45 with bicornuate uterus, 12 of which had MRI; 125 with septate uterus (18 with two cervices), 42 of which had MRI (six with two cervices); 96 with arcuate uterus, three of which had MRI; and three with diethylstilbestrol (DES) iatrogenic uterine malformations, all of which had MRI. "
8.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/01/2023 - "Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery for anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs for hyperthyroidism and hypothyroidism, and aspirin and low molecular weight heparin for antiphospholipid syndrome. " 10/01/2006 - "Therapeutic proposals are preimplantation genetic diagnosis in case of abnormal karyotiping, hysteroscopic surgery for septate uterus, aspirin plus heparin in antiphospholipid-positive patients, and aspirin plus corticosteroids in systemic lupus. " 12/01/2014 - "It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C). "
9.	Messenger RNA (mRNA)IBA 01/01/2016 - "A trend toward decreased endometrial HOXA-10, HOXA-11, and ITGAV mRNA expression was detected in both SM and IM groups before myomectomy when compared to both fertile group and septate uterus. " 01/01/2016 - "We measured endometrial HOXA-10, HOXA-11, LIF, ITGB3, and ITGAV messenger RNA (mRNA) expressions levels before and after myomectomy/metroplasty during mid-luteal phase in participants with IM, submucosal leiomyomas (SM), and septate uterus and fertile participants without fibroids. " 09/01/2009 - "To compare the messenger RNA (mRNA) expression of vascular endothelial growth factor (VEGF) receptors (KDR, Flt-1, and sflt) in the different endometrial locations of septate uterus and normal uterus. "
10.	Progesterone FDA LinkGeneric 01/01/1997 - "Early prophylactic cerclage according to the Shirodkar and McDonald technique was done on all cases of uterine malformation (except septate uterus) with or without cervical incompetence in association with progesterone and antispastic therapy. " 06/01/1994 - "However, several safeguards should be taken: laparoscopic or sonographic guidance should accompany hysteroscopic metroplasty; postoperative HSG or hysteroscopy is recommended; there is no advantage of IUD insertion postoperatively; sequential estrogen-progesterone therapy postoperatively is optional, but of no proved benefit; a hysteroscopic approach toward uterine septum is the preferred procedure, even when laparotomy for treatment of pelvic endometriosis or intrapelvic adhesions is indicated, and, although its value is not established, a short perioperative cause of prophylactic antibiotics seems to be warranted."

Therapies and Procedures

1.	Stents 11/29/2023 - "Efficacy of intrauterine balloon stent or oral estrogen on prevention of adhesion after transcervical resection of septum in septate uterus: Study protocol for a randomized controlled multicenter study in China."
2.	Electrodes (Electrode) 09/01/2007 - "Small-diameter hysteroscopy with bipolar electrode for the incision of uterine septum is as effective as resectoscopy with unipolar electrode regarding reproductive outcome and is associated with shorter operating time and lower complication rate." 01/01/2022 - "Hysteroscopic partial and complete uterine septum incisions with a 7-mm unipolar knife electrode. " 02/01/2001 - "All patients with diagnosis of uterine septum detected by transvaginal color Doppler (TVCD) underwent operative hysteroscopy in which the most prominent part of the septum was encircled with a hysteroscopic loop electrode and removed. "
3.	Laparoscopes (Laparoscope) 01/01/2015 - "Both ultrasound and laparoscope monitored TCRS were safe and effective in the treatment of uterine septum. "
4.	Therapeutics 01/01/2017 - "The result of this study indicated that hormonal therapy complications following hysteroscopic resection of septate uterus in both protocols was the same." 06/01/2016 - "The incidence of post-operative adhesion following transection of uterine septum: a cohort study comparing three different adjuvant therapies." 03/01/2011 - "To evaluate prospectively the effect of hysteroscopic septoplasty as therapy for unexplained primary infertility in women with uterine septum as a sole cause for reproductive failure and to define the factors influencing reproductive success. " 01/01/1997 - "Early prophylactic cerclage according to the Shirodkar and McDonald technique was done on all cases of uterine malformation (except septate uterus) with or without cervical incompetence in association with progesterone and antispastic therapy. " 12/01/1987 - "Newer approaches include the hysteroscopic resection of the uterine septum and medical therapy with GnRH analogues for reduction of fibroid size, volume, and symptoms. "
5.	Operative Surgical Procedures 01/01/2023 - "This study aimed to develop and describe a novel surgical procedure that involves hysteroscopic fenestration with precise incision of the complete uterine septum and double cervix preservation after magnetic resonance imaging (MRI) evaluation in patients and to evaluate its efficacy. " 01/01/2023 - "Hysteroscopic fenestration with precise incision of the uterine septum and double cervix preservation is an effective surgical procedure." 01/01/2020 - "In case of a diagnosis of a partial or complete uterine septum, magnetic resonance imaging or 3-dimensional ultrasound were performed, and surgical procedures were performed after diagnostic laparoscopy was used to better visualize the uterine fundus. " 01/01/2016 - "Data were collected with regard to medical and reproductive histories, diagnosis of septate uterus, surgical procedures, and complications. " 04/01/2004 - "To evaluate the effectiveness of hysteroscopic metroplasty under laparoscopic guidance in the treatment of infertile women with a diagnosis of septate uterus and the impact of this surgical procedure on reproductive outcome. "