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Danazol (Azol)

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.

Also Known As:

Azol; Danocrine; Alphapharm Brand of Danazol; Antigen Brand of Danazol; Cyclomen; Danatrol; Danazant; Danazol-ratiopharm; Danol; Danoval; Kendrick Brand of Danazol; Ladogal; Norciden; Panacrine; Sanofi Brand of Danazol; Sanofi Synthelabo Brand of Danazol; Sanofi Winthrop Brand of Danazol; ratiopharm Brand of Danazol; Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17alpha)-

Networked: 1127 relevant articles (151 outcomes, 152 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Pregnanes: 3
    - Pregnadienes
      - Danazol: 1127
        TAD protocol: 1
        17-hydroxy-2-(hydroxymethyl)-17-pregn-4-en-20-yn-3-one
        17-hydroxy-2-(hydroxymethyl)-17-pregna-1,4-dien-20-yn-3-one
        21-chloro-6-dehydrodanazol
        21-chlorodanazol
        isodanazol

Experts

1.	Lethaby, A: 8 articles (01/2008 - 01/2000)
2.	Farkas, Henriette: 6 articles (01/2014 - 04/2005)
3.	Varga, Lilian: 6 articles (01/2014 - 04/2005)
4.	Bork, Konrad: 6 articles (03/2011 - 05/2002)
5.	Füst, George: 5 articles (03/2011 - 04/2005)
6.	Duckitt, K: 5 articles (01/2007 - 01/2000)
7.	Farquhar, C: 5 articles (01/2007 - 01/2000)
8.	Augood, C: 5 articles (01/2007 - 01/2000)
9.	Hughes, E: 5 articles (01/2007 - 01/2000)
10.	Vandekerckhove, P: 5 articles (01/2007 - 01/2000)

Related Diseases

1.	Endometriosis (Adenomyosis) 03/01/1989 - "Although the high pretreatment level of serum CA 125 decreased after danazol treatment of 400 mg/day to within the normal limits, usually within 4 to 12 weeks, laparoscopic examinations indicated that most of the endometriosis cases were not cured until 12-16 weeks of danazol treatment." 01/01/1979 - "Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. " 07/01/1976 - "Nineteen of the 40 patients in the study had a secondary diagnosis of pelvic endometriosis confirmed histologically, and all these patients showed a marked improvement of symptoms during the Danazol treatment. " 10/15/1981 - "The results of large clinical studies suggest that danazol treatment produces significant improvement in the symptoms, signs, and laparoscopic findings of endometriosis. " 11/01/1990 - "This review suggests that endometrioma of the intestine requires a high index of suspicion for diagnosis and that danazol does not appear to be effective treatment for these patients."
2.	Pain (Aches) 03/01/2014 - "Danazol treatment is highly effective in relieving pain and decreasing CA-125 concentrations in the plasma. " 06/01/1982 - " The use of a newsteroidal agent, danazol, on a 3-6 month trial of 100-400 mg/day will eliminate pain and nodosities in some 69% of women and in another 30% the signs and symptoms will be diminished." 01/01/1979 - "The preliminary results of a double-blind randomized cross-over trial of danazol versus placebo in patients with severe cyclical breast pain are reported. " 01/01/2012 - "For lumbosacral pain, rectal discomfort, or vaginal nodules tenderness, there was no significant difference between CHM and danazol. " 06/01/2011 - "In Danazol group 69.44% women achieved reduction in pain score to ≤ 3 (p = 0.001). "
3.	Hereditary Angioedemas 01/01/1988 - "A 24-year-old woman, having familial hereditary angioneurotic edema (HAE) treated with danazol, developed an anti-Ro-positive lupus featured by a mild erythematous eruption that seemed initially to decrease and then worsened under danazol, and dramatically improved after danazol was withdrawn. " 05/01/1980 - "Danazol is an effective agent for the prophylaxis of the recurrent attacks of mucocutaneous and visceral swelling which occur in patients with hereditary angioedema (HAE). " 04/01/1979 - "Danazol, an attentuated androgen, has been suggested as an effective agent for the prophylaxis of attacks of hereditary angioedema. " 04/01/1999 - "This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures. " 03/01/2011 - "Long-term efficacy of danazol treatment in hereditary angioedema."
4.	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 08/01/1987 - "Although danazol is effective in the treatment of idiopathic thrombocytopenic purpura, its long-term safety and optimal dosage are not well established. " 03/01/1987 - "Thus, danazol appears to be an effective immune modulator, correcting the abnormality of T-cell subsets seen in autoimmune thrombocytopenia by increasing the percentage of Thi lymphocytes." 06/01/1992 - "Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy." 11/01/1989 - "Long-term danazol therapy in autoimmune thrombocytopenia: unmaintained remission and age-dependent response in women." 10/01/2008 - "[Danazol - effective second line therapy in idiopathic thrombocytopenic purpura in children. "
5.	Angioedema 05/01/2002 - "The danazol treatment relieved the symptoms of angioedema and increased the C1 INH activity and concentration with the normalization of CH50, C1q and C4 levels. " 04/01/1990 - "She responded well to danazol and had no further attacks of angioedema." 05/01/2012 - "Although the anabolic steroid, danazol, is useful in increasing the concentration of C4 and reducing the episodes of angioedema in HAE and AAE, it has expected adverse effects. " 11/01/2003 - "The angioedema was controlled with Danazol and Stanasol. " 06/01/2003 - "The angioedema was controlled with Danazol and Stanasol. "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Leuprolide (Lupron)
3.	Nafarelin (Synarel)
4.	Gestrinone
5.	Danazol (Azol)
6.	Inosine Triphosphate (ITP)
7.	Hormones
8.	Progestins (Progestagens)
9.	Estrogens (Estrogen)
10.	Buserelin (Suprefact)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Intrauterine Devices (Intrauterine Device)
3.	Drug Therapy (Chemotherapy)
4.	Ovariectomy (Oophorectomy)
5.	Plasma Exchange