Silicones

A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)

Also Known As:

Networked: 5429 relevant articles (291 outcomes, 541 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Kevin C: 13 articles (12/2015 - 05/2008)
2.	McLaughlin, Joseph K: 12 articles (05/2011 - 02/2003)
3.	Mustoe, Thomas A: 11 articles (01/2012 - 03/2002)
4.	Kim, Hojoong: 10 articles (08/2014 - 11/2006)
5.	Findl, Oliver: 10 articles (08/2014 - 05/2003)
6.	Sacu, Stefan: 10 articles (04/2009 - 01/2004)
7.	Menapace, Rupert: 10 articles (04/2009 - 05/2003)
8.	Wong, David: 8 articles (02/2015 - 03/2006)
9.	Suh, Gee Young: 8 articles (08/2014 - 05/2009)
10.	Koh, Won-Jung: 8 articles (08/2014 - 05/2009)

Related Diseases

1.	Cicatrix (Scar) 01/01/2013 - "In treatment studies, silicone gel sheeting produced a statistically significant reduction in scar thickness (mean difference (MD) -2.00, 95% CI -2.14 to -1.85) and colour amelioration (RR 3.49, 95% CI 1.97 to 6.15) but again these studies were highly susceptible to bias. " 05/01/2002 - "In most cases reconstruction with Skin-Expander and silicone implants meets the patients' desires: low-risk operation, fewer additional scars, and similar and improved breasts on both sides." 05/01/2006 - "All parameters in the Vancouver Scar Scale improved in both groups, although patients treated with the soft silicone dressing showed greater and more rapid improvements compared with the non-treated patients, while their assessments of the condition of the scar were more favourable. " 01/01/1994 - "After silicone gel application, three of the five scars showed initial positive results including reduction in the scar size, reduction in the scar thickness, softening of the scar, a decrease in vascularity of the scar, and more uniform pigmentation. " 06/01/1999 - "Both the silicone gel cushion and the silicone gel sheeting treatments were effective in decreasing scar volume, 53.0% and 36.3%, respectively. "
2.	Retinal Detachment (Retinal Detachments) 07/01/1991 - "Because many complicated cases of retinal detachment can also be treated successfully with gas tamponade, silicone oil should remain the last step in retinal detachment surgery." 01/01/1990 - "Because many complicated cases of retinal detachment can also be treated successfully with gas tamponade, silicone oil should remain the last option in retinal detachment surgery." 01/01/1996 - "Silicone oil tamponade was effective for the treatment of retinal detachments with proliferative vitreo-retinopathy. " 04/01/2001 - "The systematic use of these surgical steps can be very useful in the management of retinal detachment relapses in eyes previously treated with silicone oil injection." 06/01/1999 - "The advent of silicone oil tamponade has resulted in improved success rates in complicated retinal detachment surgery. "
3.	Hypertrophic Cicatrix (Hypertrophic Scar) 07/01/2009 - "This pilot study investigates whether pressure and silicone therapy used simultaneously are more effective in treating multiple characteristics of hypertrophic scars than pressure alone. " 01/01/2008 - "Although controlled trials in larger series of patients are necessary, our results suggest that the self-drying silicone gel may represent a safe and effective treatment for hypertrophic scars." 10/01/2010 - "Topical silicone therapy probably will continue to be the preferred first-line treatment for hypertrophic scars due to its availability, price, ease of application, lack of serious adverse effects, and relative efficacy. " 10/01/1989 - "Topical silicone gel: a new treatment for hypertrophic scars." 10/01/2011 - "The efficacy of silicone spray therapy was comparable to that of silicone gel sheet therapy in the prevention of hypertrophic scars. "
4.	Keloid 04/01/2015 - "Use of silicone sheeting has also been demonstrated to be effective in the treatment of minor keloids in association with corticosteroid intralesional infiltration. " 03/01/2004 - "To study the curative effects of keloid by operation combined with postoperative beta radiation and silicone gel sheeting. " 01/01/2015 - "It is suggested that, in the space beneath the silicone sheet, the higher humidity and temperature, both generated as a result of prolonged sheeting, especially during hot weather, might have caused the keloid and its neighbouring skin to become soggy. " 04/01/2014 - "Ten patients presenting with 22 ear keloids were enrolled into a keloid protocol: (a) surgical excision and keloid rind flap cover with (b) intra-operative and post-operative intra-lesional steroid and (c) silicone sheet application. " 08/01/2002 - "In addition topical treatment with extracts of onions, occlusive silicone sheets and pressure improves the clinical appearance of keloids."
5.	Retinal Perforations 11/01/1998 - "Silicone oil tamponade of macular holes is effective and safe. " 11/01/2007 - "To determine whether the efficacy of re-operation for idiopathic full-thickness macular hole (FTMH) remaining open after initial surgery with internal limiting membrane (ILM) peeling is correlated with macular hole configuration as determined by optical coherence tomography (OCT), macular hole size, macular hole duration before the first operation, or type of tamponade (gas or silicone oil). " 12/01/2015 - "COHORT SAFETY AND EFFICACY STUDY OF SILURON2000 EMULSIFICATION-RESISTANT SILICONE OIL AND F4H5 IN THE TREATMENT OF FULL-THICKNESS MACULAR HOLE." 05/01/2005 - "Further studies are necessary to evaluate whether a DF is advantageous in respect to silicone oil filling alone in case of retinal breaks and PVR of the inferior retina." 03/01/2002 - "This study reviews our experience of macular hole surgery using silicone oil tamponade with no restriction of posturing. "

Related Drugs and Biologics

1.	Hydrogel
2.	Retinaldehyde (Retinal)
3.	Polypropylenes (Polypropylene)
4.	Polymers
5.	Silver
6.	Polytetrafluoroethylene (Teflon)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Polymethyl Methacrylate (Sol)
9.	Polyurethanes (Polyurethane)
10.	baysilon (polydimethylsiloxane)

Related Therapies and Procedures

1.	Vitrectomy
2.	Stents
3.	Catheters
4.	Lasers (Laser)
5.	Injections