Tazobactam Drug Combination Piperacillin (Zosyn)

An antibiotic combination product of piperacillin and tazobactam, a penicillanic acid derivative with enhanced beta-lactamase inhibitory activity, that is used for the intravenous treatment of intra-abdominal, pelvic, and skin infections and for community-acquired pneumonia of moderate severity. It is also used for the treatment of PSEUDOMONAS AERUGINOSA INFECTIONS.

Also Known As:

Zosyn; Tazocin; Piperacillin, Tazobactam Drug Combination; Piperacillin - Tazobactam; Piperacillin-Tazobactam Combination Product; Pipercillin Sodium - Tazobactam Sodium; Pipercillin Sodium, Tazobactam Sodium Drug Combination; Tazocel; Tazocillin; Piperacillin Tazobactam; Piperacillin Tazobactam Combination Product; Pipercillin Sodium Tazobactam Sodium; Tazobactam, Piperacillin -

Networked: 1474 relevant articles (148 outcomes, 286 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Roberts, Jason A: 33 articles (08/2022 - 03/2009)
2.	Lipman, Jeffrey: 25 articles (01/2022 - 07/2007)
3.	Nicolau, David P: 22 articles (10/2021 - 04/2002)
4.	Paterson, David L: 17 articles (01/2022 - 12/2007)
5.	Kuti, Joseph L: 15 articles (09/2015 - 04/2002)
6.	Wallis, Steven C: 11 articles (08/2022 - 05/2013)
7.	Woods, Gail L: 11 articles (06/2004 - 01/2002)
8.	Teppler, Hedy: 10 articles (08/2005 - 01/2002)
9.	Lodise, Thomas P: 9 articles (01/2021 - 12/2004)
10.	Kaye, Keith S: 8 articles (12/2021 - 08/2007)

Related Diseases

1.	Infections 08/01/2004 - "An empiric therapeutic approach with piperacillin/tazobactam is highly effective in biliary tract infections due to benign or malignant conditions." 02/01/2002 - "The concentrations achieved in synovial tissue are above the MICs of most of the susceptible pathogens usually involved in joint infections, which suggests that the piperacillin/tazobactam combination should be effective in the treatment of most joint infections caused by susceptible microorganisms." 07/01/1994 - "These findings show that piperacillin/tazobactam is truly synergistic combination which can be expected to be effective in treating a wide variety of infections in the clinical setting." 04/01/2023 - "Clinical data suggest improved outcomes when piperacillin/tazobactam is prescribed for Enterobacterales infections with an MIC of ≤16/4 mg/L compared with ≥32/4 mg/L." 08/01/2018 - "To determine the clinical and micro-biological cure with piperacillin/tazobactam in patients with infections caused by E. "
2.	Intraabdominal Infections 07/01/1994 - "Results of these clinical trials and others have shown that piperacillin/tazobactam is a safe and effective alternative to either combination or monotherapy for intra-abdominal infections." 12/01/1992 - "Results of the present study show that piperacillin-tazobactam is effective and safe for the treatment of intra-abdominal infections." 01/01/1994 - "These results support the findings of the efficacy of piperacillin/tazobactam in treating intraabdominal infections in human clinical trials." 05/01/1995 - "In this limited series of 23 patients suffering from severe or life-threatening intra-abdominal infection, piperacillin + tazobactam, together with adequate surgical drainage and resections, cured 78% of our patients and eradicated almost all the pathogens. " 01/01/1994 - "Efficacy of piperacillin/tazobactam in the treatment of experimental intra-abdominal infections."
3.	Fever (Fevers) 02/25/1995 - "A combined regimen of piperacillin/tazobactam can be proposed as first line treatment for neutropenic patients with fever." 09/01/2023 - "However, she developed a fever again on the fourth day of treatment with piperacillin-tazobactam. " 05/01/2019 - "In Qatar and worldwide, there are few reported cases regarding bone marrow suppression or fever induced by piperacillin/tazobactam in general and during pregnancy. " 11/01/2015 - "The fever lasted for 2 weeks and her body temperature come back to normal 4 days after piperacillin/tazobactam cessation.Fever" 11/01/2015 - "She developed a fever after an intake of piperacillin/tazobactam for 3 days. "
4.	Febrile Neutropenia 09/01/2015 - "The study results in Japanese patients with febrile neutropenia demonstrate that tazobactam/piperacillin treatment is efficacious and safe in adults. " 01/01/2019 - "PIPERACILLIN/TAZOBACTAM IN CONTINUOUS INFUSION VERSUS INTERMITTENT INFUSION IN CHILDREN WITH FEBRILE NEUTROPENIA." 09/01/2015 - "Efficacy and safety of tazobactam/piperacillin as an empirical treatment for the patients of adult and child with febrile neutropenia in Japan." 07/01/2013 - "Piperacillin-tazobactam as a cost effective monotherapy in febrile neutropenia." 11/01/2008 - "This prospective study investigated different sampling times in 30 patients receiving piperacillin/tazobactam for febrile neutropenia. "
5.	Neoplasms (Cancer) 09/01/2023 - "Piperacillin-tazobactam use ranged from 9.1% to 28.0% in the pulmonary and cancer subgroups, respectively. " 10/01/2019 - "Piperacillin-tazobactam concentration target attainment in children with cancer." 11/01/2007 - "Piperacillin-tazobactam in pediatric cancer patients younger than 25 months: a retrospective multicenter survey." 10/01/2006 - "The low content of GM 8 h after piperacillin/tazobactam infusion suggests that in non-neutropenic cancer patients with solid tumours receiving up to three doses of piperacillin/tazobactam, serum sampling for GM detection should be performed immediately before the next piperacillin/tazobactam administration." 03/01/2006 - "Piperacillin-tazobactam monotherapy in high-risk febrile and neutropenic cancer patients."

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4.	Cefepime (Maxipime)
5.	Ceftazidime (Fortum)
6.	Vancomycin
7.	Amikacin (A.M.K)
8.	Carbapenems (Carbapenem Antibiotics)
9.	Gentamicins (Gentamicin)
10.	Imipenem Drug Combination Cilastatin (Primaxin)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Continuous Renal Replacement Therapy
4.	Length of Stay
5.	Drug Therapy (Chemotherapy)