beta-Lactams

Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

Also Known As:

Networked: 710 relevant articles (51 outcomes, 70 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roberts, Jason A: 9 articles (10/2015 - 08/2008)
2.	Lipman, Jeffrey: 8 articles (12/2013 - 08/2008)
3.	Demoly, P: 8 articles (03/2010 - 10/2004)
4.	Turos, Edward: 8 articles (09/2008 - 06/2002)
5.	Nicolau, David P: 6 articles (11/2014 - 01/2005)
6.	Blanca, Miguel: 5 articles (02/2014 - 01/2006)
7.	Mayorga, Cristobalina: 5 articles (02/2014 - 01/2006)
8.	Paul, Mical: 5 articles (01/2014 - 03/2004)
9.	Leibovici, Leonard: 5 articles (01/2014 - 03/2004)
10.	Blanca, M: 5 articles (01/2013 - 07/2001)

Related Diseases

1.	Infection 08/01/2014 - "The best results were observed in the group of beta-lactams and in the treatment of respiratory and skin infections. " 06/01/1994 - "5. Above results indicate that ABK is effective in MRSA infection, and combined therapy with beta-lactams is superior to other methods in serious MRSA infections. " 02/01/1996 - "Lower MIC50 or MIC90 was observed at ISP concentrations of 4 approximately 16 micrograms/ml. 3. The blood Cmax of ISP exceeded 20 micrograms/ml at one-time administration of ISP 400 mg, and these results suggested that antibacterial activities of combination uses of ISP and beta-lactams was clinically effective against MRSA infections." 12/01/2014 - "This study highlights the need to collect more national resistance data (particularly regarding beta-lactams) to create stronger evidence-based treatment guidelines for skin infections in Europe." 08/01/1995 - "This study demonstrates that X. maltophilia infection is an emerging cause of morbidity in tropical regions where endemic infections require the use of broad-spectrum beta-lactams."
2.	Pneumonia (Pneumonitis) 01/01/2015 - "P. multocida is commonly susceptible to most beta-lactams, including those utilized for the treatment of community acquired pneumonia. " 03/01/2002 - "However, Streptococcus pneumoniae, the most common etiologic agent of community-acquired pneumonia, has become increasingly resistant to beta-lactams over the past decade. " 05/01/2008 - "As Legionella is likely to present as severe pneumonia and does not respond to beta-lactams, it is important to presumptively diagnose Legionnaires' disease clinically so that Legionella coverage is included in empiric therapy. " 04/01/2000 - "pneumoniae infection in a beta-lactams-resistant community-acquired pneumonia, whatever its severity may be, and to start macrolide antibiotherapy. " 09/04/1999 - "influenzae, it is important to determine whether pristinamycin, with known efficacy against these germs, could be a useful alternative to beta-lactams for the treatment of adult acute community-acquired pneumonia. "
3.	Hypersensitivity (Allergy) 04/01/2007 - "Our data show that the new test kit may be helpful in detecting patients with immediate type allergy to beta-lactams. " 04/01/2007 - "PPL and MDM skin test: new test kit is helpful in detecting immediate-type allergy to beta-lactams." 06/01/2015 - "Secondary care studies showed that a recorded allergy to beta-lactams could not be confirmed by valid allergy testing in >85% of cases. " 10/01/2012 - "Many children with adverse reactions to beta-lactams are labeled as allergic without performing an allergy study to confirm it. " 08/28/2009 - "Genetic studies indicate that these agents target SAV1754 based on the following observations: (i) it has a unique chemical hypersensitivity profile, (ii) overexpression or point mutations are sufficient to confer resistance, and (iii) genetic inactivation phenocopies the potentiating effect of these agents in combination with beta-lactams. "
4.	Bacteremia 03/01/1989 - "One hundred Gram-positive bacteremia organisms from five important genus groups were tested against 10 newer beta-lactams. " 04/01/2003 - "To describe the incidence of pneumococcal bacteremia not associated with infection of the central nervous system, investigate the susceptibility of bacterial isolates to beta-lactams, evaluate risk factors for antibiotic resistance, and determine factors predicting patient outcome. " 03/01/2006 - "The study presented here investigated the impact of initial antibiotic choice (beta-lactams vs vancomycin) on the outcome of 342 patients with Staphylococcus aureus bacteremia (50.9% with methicillin-resistant isolates) encountered between 1 January 2002 and 30 June 2003. " 10/01/1999 - "A case-control clinical study showed that the interval between admission and bacteremia, admission to the intensive care unit, prior use of vancomycin and/or beta-lactams, and isolation of methicillin-resistant staphylococci were significantly more common among patients with bacteremia due to staphylococci with heteroresistance to vancomycin; these patients had an overall mortality of 44.4%. " 07/15/2011 - "Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding."
5.	Pneumococcal Infections 10/01/2003 - "In response to these recent clinical studies showing that non-meningeal pneumococcal infections with strains classified as resistant in vitro still responded well to treatment with various beta-lactams, new breakpoints have been set. " 03/07/2008 - "It is anticipated that definition of the minimal structural features of MurM substrates will allow development of novel resistance inhibitors that will restore the efficacy of beta-lactams for treatment of pneumococcal infection." 01/01/1985 - "Its clinical presentation is very suggestive, especially after the failure of a 48 hour therapeutic trial of beta-lactams, when a pneumococcal infection is initially suspected. " 01/01/2010 - "Multiresistant Streptococcus pneumoniae infections are of great concern as treatment failures may occur with commonly used treatment regimens using beta-lactams and macrolides. " 07/01/2009 - "In recent decades, the increase of Streptococcus pneumoniae strains resistant to beta-lactams, to other classes of antimicrobial drugs and especially to penicillin (penicillin-resistant pneumococcus - PRP) has further complicated the treatment of pneumococcal infection. "

Related Drugs and Biologics

1.	Aminoglycosides
2.	Penicillins (Penicillin)
3.	beta-Lactamases (beta-Lactamase)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Carbapenems (Carbapenem Antibiotics)
6.	Quinolones
7.	Glycopeptides
8.	Ciprofloxacin (Cipro)
9.	Tetracyclines
10.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Catheters
3.	Aftercare (After-Treatment)
4.	Intensive Care (Surgical Intensive Care)
5.	Hematopoietic Stem Cell Transplantation