Drug Combinations

08/01/2009 - "However, the divergent biological responses induced by the different compounds, even in the same tumor cells, demand additional mechanistic insights, whose knowledge may lead to improved drug design or selection of the most potent drug combinations. "
03/19/2015 - "In perspective, the strategy proposed here to target synergistic drug combinations through HA-decorated nanoparticles seems very attractive to improve the specificity and efficacy of cancer treatment."
01/01/2015 - "In vitro-based search for promising anti-cancer drug combinations may provide important leads to improved cancer therapies. "
02/01/1984 - "There was no improvement in response rate or survival time from two alternating drug combinations evaluated in an attempt to achieve more marked tumor reductions and to delay the emergence of resistant subclones. "
01/01/2012 - "Improved targeted therapies, with drug properties favorable to intracranial tumors, are likely required to form effective drug combinations for GBM."

10/09/1976 - "The best prospect for improved management of hypertension probably lies in earlier treatment with current drug combinations."
08/01/2009 - "Guidelines recommend drug-drug combinations as a first-line treatment in high-risk patients with severe hypertension, or as an escalation for patients not controlled on monotherapy. "
03/01/2009 - "Although combination therapy is superior to monotherapy in achieving BP goals across the entire spectrum of hypertension, the proportion of patients achieving the recommended BP goal can be further improved by the use of new antihypertensive drug combinations. "
03/22/2012 - "[Hypertension: improved therapy adherence after switch to a fixed drug combinations]."
05/01/2006 - "Fixed-drug combinations as first-line treatment for hypertension."

08/01/2011 - "Results helped to illustrate dynamic changes primarily involved in inducing apoptotic activities on drug exposure of leukemia cells, thereby facilitating us to integrate different drug combinations in a more specific manner in near future to study CML in clinical settings."
04/01/2004 - "This, in turn, has improved the possibilities of designing and developing better drugs and drug combinations in leukemia. "
05/01/1980 - "The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. "
05/01/2009 - "Future clinical approaches may include drug combinations, which may allow quiescent leukemia stem cells to be eradicated. "
01/01/1981 - "Androgen therapy during myeloblastic leukemia remission induced by two drug combinations."

10/01/2006 - "In the future, appropriate drug combinations, drug concentrations and duration of preventive strategies need to be determined to be most beneficial for the management of acute and chronic pain after surgery."
07/01/2006 - "Overall analgesic efficacy of the drug combinations was assessed for 7 days postoperatively using a 4-point categorical pain-intensity rating scale (0 = no pain; 1 = mild pain; 2 = moderate pain; and 3 = severe pain). "
01/01/2005 - "The overall analgesic efficacy of the drug combinations was assessed postoperatively by determination of pain intensity using a category rating scale. "
09/01/2009 - "The polyanalgesic initiative aims to summarize the current knowledge and to facilitate rational choices of intrathecal drug and drug combinations for the management of chronic pain. "
08/01/2007 - "For each patient, considerations on the underlying pain mechanisms, immediate and potential long-term side effects, and price as well as comorbidities and concurrent medications will decide which drug should be the first choice, but until further progress is made towards a mechanism-based classification, treatment is likely to be a trial-and-error process where drug combinations may also be considered."

10/01/1986 - "In addition, available clinical evidence suggests that synergistic drug combinations are most effective in the treatment of infections due to Pseudomonas aeruginosa. "
03/01/2015 - "In order to develop improved drug combinations that effectively target diverse mycobacterial phenotypes, it is important to understand how such subpopulations of M.tb are formed during human infection. "
08/14/1992 - "Although such infections are not a major problem in numerical terms, the variable response of patients to treatment means that conventional sensitivity testing is of little assistance, and it is necessary to seek evidence of synergy in drug combinations for the effective treatment of these infections."
01/01/2012 - "Large randomised controlled trials are required to compare antifungal drugs, drug preparations or drug combinations for treating newborn infants with invasive fungal infection."
04/01/1994 - "We compared the in vitro efficacies of two-, three-, and four-drug combinations given continuously or in alternating regimens against a clinical isolate of human immunodeficiency virus type 1. In H9 cells and peripheral blood mononuclear cells, at the drug concentrations used in this study, there was greater suppression of human immunodeficiency virus type 1 infection as the number of drugs in the regimen was increased from one to four simultaneously administered agents. "