Drug Fever Induced by Piperacillin/Tazobactam in a Scoliosis Patient: A Case Report.

Abstract

Drug fever is frequently underrecognized by clinicians despite its common occurrence. Fever induced by piperacillin/tazobactam has not been reported in scoliosis correction surgery.Drug fever caused by piperacillin/tazobactam in a scoliosis patient was described.A 36-year-old woman with adult scoliosis undergoing correction surgery was reported. She developed a fever after an intake of piperacillin/tazobactam for 3 days. Eosinophil count, erythrocyte sedimentation rate, and C-reactive proteins were increased in her blood examination. Thorough history, chest radiography, blood cultures, physical examination, and urinalysis revealed no evidences of fever. A drug fever is therefore considered. The fever lasted for 2 weeks and her body temperature come back to normal 4 days after piperacillin/tazobactam cessation.Fever could be caused by piperacillin/tazobactam. The drug fever's diagnosis is easily confounded by a co-occurring infection. Therefore, it is crucial for clinicians to doubt drugs as a reason when no other origin of fever could be identified in a patient.

• Authors: Zheng Li, Jianxiong Shen, Qiyi Li, Matthew Tak Vai Chan, William Ka Kei Wu
• Journal: Medicine (Medicine (Baltimore)) Vol. 94 Issue 46 Pg. e1875 (Nov 2015) ISSN: 1536-5964 [Electronic] United States
• PMID: 26579799 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Drug Combinations
• Piperacillin, Tazobactam Drug Combination
• Penicillanic Acid
• Piperacillin

Topics

• Adult
• Anti-Bacterial Agents (adverse effects)
• Drug Combinations
• Female
• Fever (chemically induced, diagnosis)
• Humans
• Penicillanic Acid (adverse effects, analogs & derivatives)
• Piperacillin (adverse effects)
• Piperacillin, Tazobactam Drug Combination
• Postoperative Complications (chemically induced, diagnosis)
• Scoliosis (surgery)