Naproxen (Naprosyn)

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Also Known As:

Networked: 1645 relevant articles (279 outcomes, 486 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Wallace, John L: 9 articles (06/2015 - 03/2010)
2.	Moore, R Andrew: 8 articles (01/2015 - 01/2009)
3.	Lener, Shelly E: 8 articles (05/2014 - 01/2007)
4.	McDonald, Susan A: 8 articles (05/2014 - 01/2007)
5.	Fort, John G: 7 articles (07/2015 - 07/2004)
6.	Derosier, Frederick J: 7 articles (05/2014 - 07/2009)
7.	Derry, Sheena: 7 articles (01/2013 - 01/2009)
8.	Hochberg, Marc C: 7 articles (12/2011 - 12/2002)
9.	Schnitzer, Thomas J: 7 articles (02/2011 - 02/2003)
10.	Goldstein, J L: 7 articles (11/2010 - 04/2001)

Related Diseases

1.	Pain (Aches) 01/01/1983 - "In the naproxen group, there was a significant improvement in articular index, grip strength and pain severity over the study. " 07/01/1989 - "Within 1.5 h after the end of surgery, pain scores were significantly improved in patients receiving naproxen (P less than 0.02). " 01/01/1987 - "The efficacy results revealed significant improvement in all five parameters for each medication except measurement of pain with respect to a defined activity for naproxen (p less than 0.07). " 01/01/1983 - "Naproxen produced significant improvement in three parameters: pain at rest, duration of morning stiffness, and number of swollen joints. " 06/01/2006 - "Knee patients treated with naproxen improved 4.6 (p = 0.033) more than hip patients for SF-36 bodily pain and 10.3 (p = 0.014) more for SF-36 role-physical. "
2.	Osteoarthritis 02/01/1975 - "In a previous open clinical trial with d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) in 32 outpatients with osteoarthrosis, very good to good results were achieved in 6 patients, satisfactory in 12, fair in 5, and unsatisfactory in 9 patients. " 01/01/1991 - "Improved cost-effectiveness ratio with a patient self-adjusted naproxen dosing regimen in osteoarthritis treatment." 11/01/2014 - "The aim of our study was to investigate the effects of naproxen, an antiinflammatory analgesic drug, on brain response to painful stimulation on the affected knee in chronic osteoarthritis (OA) using functional magnetic resonance imaging (fMRI) in a double-blind, placebo-controlled study. " 06/01/2014 - "Seventy-nine men and women (40-90 years old) diagnosed as having mild to moderate osteoarthritis (OA) consumed either 500 mg/day of the UP446 supplement or 440 mg/day of naproxen for 1 week in a double-blind randomized control trial. " 03/01/2014 - "In the context of part I of this paper in characterizing hand osteoarthritis (OA), we review clinical trials that have been conducted involving hand OA and naproxen. "
3.	Rheumatoid Arthritis 10/01/1979 - "Because of its relatively long plasma half-life, naproxen can with convenieice be given twice daily, and there is some evidence that once daily dosage is as effective in rheumatoid arthritis." 09/01/2012 - "Out of 2869 identified studies only a single open-arm trial fulfilled inclusion criteria assessing the safety and efficacy of naproxen in 58 patients with active rheumatoid arthritis and GI comorbidities. " 01/01/2012 - "This trial assessed the safety and efficacy of naproxen (dosage not specified) in 58 patients with active rheumatoid arthritis and gastrointestinal comorbidities for up to 52 weeks. " 01/01/1983 - "Double-blind crossover study to evaluate the efficacy of a single daily dose of naproxen in rheumatoid arthritis." 04/30/1988 - "After a reminder of the major points of the pharmacokinetics of non-steroid anti-inflammatory drugs, the authors report the results of a multicentric study of the kinetics of naproxen after oral intake of one single dose of 1 gram in patients with rheumatoid arthritis. "
4.	Migraine Disorders (Migraine) 01/01/2013 - "Naproxen is not clinically useful as a stand-alone analgesic in acute migraine, as it is effective in fewer than 2 people in 10." 01/01/2000 - "Naproxen is shown to be effective in prophylactic treatment of migraine. " 01/01/2013 - "We design and perform a randomized controlled clinical trial to evaluate the efficacy of acupuncture compared with naproxen in menstrual-related migraine patients. " 01/01/2013 - "We included randomised, double-blind, placebo- or active-controlled studies, with at least 10 participants per treatment arm, using naproxen alone or with an antiemetic to treat a migraine headache episode. " 05/01/2010 - "We identified 16 published randomized controlled trials of naproxen in the treatment of migraine. "
5.	Dysmenorrhea (Menstrual Pain) 02/01/2002 - "The patient had a pattern of naproxen use during menses for dysmenorrhea. " 05/01/1985 - "Also, adolescents who reported more severe dysmenorrhea symptoms following three months of naproxen therapy had significantly lower self-concepts than adolescents who reported less symptoms following treatment." 05/01/1985 - "Factors influencing adolescents' responses to regimens of naproxen for dysmenorrhea." 01/01/1983 - "Naproxen in the treatment of OC-resistant primary dysmenorrhea. " 05/01/1980 - "Severe, primary dysmenorrhea treated with naproxen. "

Related Drugs and Biologics

1.	Sodium
2.	Ibuprofen (Motrin)
3.	Diclofenac (SR 38)
4.	Aspirin (Acetylsalicylic Acid)
5.	celecoxib (Celebrex)
6.	Acetaminophen (Paracetamol)
7.	Indomethacin (Indometacin)
8.	Piroxicam (Feldene)
9.	Sumatriptan (Imigran)
10.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)

Related Therapies and Procedures

1.	Oral Administration
2.	Analgesia
3.	Ambulatory Surgical Procedures (Outpatient Surgery)
4.	Intrauterine Devices (Intrauterine Device)
5.	Aftercare (After-Treatment)