Docetaxel (Taxotere)

A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.

Also Known As:

Taxotere; Docetaxel Anhydrous; Docetaxel Hydrate; Docetaxel Trihydrate; Docetaxol; N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol; NSC 628503; RP 56976; RP-56976; Taxoltere Metro; N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol; RP56976; Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2aR,4S,4aR,6R,9S,11S,12S,12aS,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,4a ,6,11-tetrahydroxy-8,12a,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR)-, hydrate (1:3)

Networked: 12223 relevant articles (1910 outcomes, 4421 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        Docetaxel: 12223
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        Docetaxel: 12223

Experts

1.	Fizazi, Karim: 61 articles (03/2022 - 09/2004)
2.	Beer, Tomasz M: 55 articles (01/2022 - 01/2002)
3.	Petrylak, Daniel P: 54 articles (01/2022 - 08/2002)
4.	Georgoulias, V: 45 articles (11/2016 - 01/2000)
5.	Armstrong, Andrew J: 43 articles (01/2022 - 04/2005)
6.	Carducci, Michael A: 42 articles (01/2021 - 03/2002)
7.	Oudard, Stéphane: 41 articles (02/2022 - 05/2005)
8.	de Wit, Ronald: 40 articles (01/2022 - 10/2004)
9.	Chi, Kim N: 38 articles (01/2022 - 10/2004)
10.	Saad, Fred: 37 articles (10/2022 - 08/2008)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 09/15/2010 - "Docetaxel is one of the few chemotherapeutic drugs that are considered highly effective when used to treat prostate cancer patients that have relapsed and/or metastatic disease, it is therefore reasonable to expect further improvements in treatment outcomes when it is combined with other therapeutic agents active in prostate cancer. " 11/01/2014 - "Although docetaxel is still considered a mainstay of treatment in metastatic castrate-resistant prostate cancer (mCRPC), in the last few years, new agents have been developed to improve survival in this setting and reach a possible optimal personalized treatment strategy. " 01/01/2021 - "The clearance of intravenous docetaxel is higher in medically castrated prostate cancer patients as compared to patients with other types of solid tumours. " 11/01/2007 - "One of the major obstacles in curing prostate cancer is the development of drug resistance to docetaxel, which is the gold standard for the treatment of this disease. " 06/01/2013 - "Hypothesizing that GVAX for prostate cancer could be effective in a neoadjuvant setting in patients with locally advanced disease, we initiated a phase II trial of neoadjuvant docetaxel and GVAX. "
2.	Breast Neoplasms (Breast Cancer) 04/01/2021 - "Docetaxel is an anti-microtubule agent and a highly effective treatment of locally advanced and metastatic breast cancer. " 07/01/2002 - "Docetaxel has proven efficacy in metastatic breast cancer. " 04/01/2000 - "Docetaxel has proven effective in advanced breast cancer. " 01/01/2005 - "High efficacy and low toxicity of weekly docetaxel given as first-line treatment for metastatic breast cancer." 06/01/2002 - "The consistent demonstration of a high level of efficacy with manageable toxicity ensures the continued widespread investigation of docetaxel in metastatic breast cancer."
3.	Neoplasms (Cancer) 01/01/2016 - "In our study, docetaxel (DTX) notably synchronized cells in G2/M phase and pretreatment with DTX highly improved in vitro and in vivo tumor cell targeting effect of FA decorated NP (FANP). " 03/25/2023 - "Docetaxel is a highly potent anti-tumor agent which is clinically effective for the treatment of various cancers. " 01/01/2017 - "Docetaxel (DTX) is one of the most widely used drugs in oncology due to its high efficacy against several cancers. " 03/18/2015 - "By contrast, selectively inhibiting BCL-XL did not suppress granulopoiesis but was highly efficacious in combination with docetaxel when tested against a range of solid tumors. " 04/15/2014 - "In ARv567-expressing LuCap86.2 tumor xenografts, docetaxel treatment was highly efficacious, whereas ARv7-expressing LuCap23.1 tumor xenografts displayed docetaxel resistance. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/01/1999 - "Results of a multicenter phase III trial of docetaxel versus best supportive care for the first-line treatment of non-small cell lung cancer are pending. " 03/01/2016 - "To gain a better understanding of the impact of dose and other prognostic factors on safety and efficacy of docetaxel in second-line non-small-cell lung cancer patients. " 12/01/2009 - "To study a commonly used Astragalus-based herbal formula previously found effective in non-small cell lung cancer (NSCLC) on the pharmacokinetics of docetaxel in patients with NSCLC. " 09/01/2004 - "Although the validity of the results of this study is limited due to the small sample size, docetaxel appears effective in selected elderly patients with advanced non-small-cell lung cancer." 06/20/2019 - "In the present investigation, we report on the formulation and characterization of docetaxel inhalable nanoparticles as a viable alternative for effective treatment of non-small cell lung cancer as a long-term delivery choice. "
5.	Stomach Neoplasms (Stomach Cancer) 02/01/2014 - "As first-line treatment for advanced gastric cancer, docetaxel plus S-1 significantly improves median overall and progression-free survival as compared with S-1 alone. " 04/01/2020 - "Meanwhile, the efficacy of S-1 plus docetaxel has been demonstrated in Stage Ⅲ gastric cancer, and it is recommended as a standard treatment for Stage Ⅲ gastric cancer in the guidelines. " 01/01/2019 - "Addition of docetaxel to S-1 is effective with few safety concerns in patients with stage III gastric cancer. " 01/01/2013 - "Therefore, Plu-CLA is a potential intraperitoneal-route carrier for hydrophobic docetaxel for the effective treatment of peritoneal metastatic gastric cancer." 01/01/2005 - "The combination of docetaxel and capectabine was found to be well tolerated and effective in patients with advanced gastric cancer. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Fluorouracil (Carac)
3.	Gemcitabine
4.	Paclitaxel (Taxol)
5.	Hormones (Hormone)
6.	Trastuzumab (Herceptin)
7.	Docetaxel (Taxotere)
8.	Capecitabine (Xeloda)
9.	Carboplatin (JM8)
10.	Androgens

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Castration
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Neoadjuvant Therapy