Abstract | PURPOSE: PATIENTS AND METHODS:
Chemotherapy-naive elderly patients (aged at least 76 years) with locally advanced or metastatic non-small-cell lung cancer were accrued. Eligible patients received at least two cycles of docetaxel at a dose of 60 mg/m2 on day 1 over 1 h every 3 weeks. Patients who were considered ineligible for this study were also registered. Symptom control was assessed using a questionnaire during the treatment period. The pharmacokinetics of docetaxel were evaluated in the first cycle of chemotherapy. RESULTS: Of 35 elderly patients, 15 (43%) met the study eligibility criteria. The reasons for ineligibility consisted mainly of poor performance status, poor bone marrow function, and hypoxemia (six patients each). A total of 49 cycles of chemotherapy (median 2 cycles, range 1-12 cycles) were administered to the eligible patients, six of whom achieved a partial response (overall response rate 40%, 95% confidence interval 15-65%). The major toxicity was hematologic, with grade 3 or greater neutropenia and grade 3 neutropenic fever developing in 13 patients (87%) and five patients (33%), respectively. Symptoms, as assessed in terms of the symptom control score, did not clearly decline during the treatment period. The values (mean+/-SD) of Cmax, AUC(0-->inf), and t(1/2) were 1.35+/-0.32 microg/ml, 1.79+/-0.52 microg h/ml, and 4.1+/-2.3 h, respectively. CONCLUSIONS: Although the validity of the results of this study is limited due to the small sample size, docetaxel appears effective in selected elderly patients with advanced non-small-cell lung cancer.
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Authors | Nagio Takigawa, Yoshihiko Segawa, Daizo Kishino, Keiichi Fujiwara, Yoshiyuki Tokuda, Nobuhiko Seki, Tetsu Shinkai, Yoichi Watanabe, Shunkichi Hiraki, Toshiyuki Kozuki, Kenichi Gemba, Masahiro Tabata, Katsuyuki Kiura, Hiroshi Ueoka, Mitsune Tanimoto |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 54
Issue 3
Pg. 230-6
(Sep 2004)
ISSN: 0344-5704 [Print] Germany |
PMID | 15127232
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Taxoids
- Docetaxel
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Antineoplastic Agents, Phytogenic
(administration & dosage, adverse effects, pharmacokinetics)
- Area Under Curve
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Docetaxel
- Female
- Fever
(chemically induced)
- Health Status
- Humans
- Lung Neoplasms
(drug therapy)
- Male
- Neutropenia
(chemically induced)
- Taxoids
(administration & dosage, adverse effects, pharmacokinetics)
- Treatment Outcome
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