NIMA-Related Kinase 1

A NIMA-related kinase that functions in CELL CYCLE regulation, the control of CILIA assembly, and CENTROSOME duplication. It is activated at G2 PHASE CELL CYCLE CHECKPOINTS in response to DNA DAMAGE.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cui, Baolong: 1 article (04/2021)
2.	He, Xiaoyan: 1 article (04/2021)
3.	Yao, Luqing: 1 article (04/2021)
4.	Zhao, Fang: 1 article (04/2021)
5.	Zhou, Chang: 1 article (04/2021)
6.	Gao, Xin: 1 article (01/2021)
7.	Li, Yongzhe: 1 article (01/2021)
8.	Chen, Guang: 1 article (12/2019)
9.	Chen, Jie: 1 article (12/2019)
10.	Ding, Xiao-Fei: 1 article (12/2019)

Related Diseases

1.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/01/2023 - "Loss-of-function variants in NIMA-related kinase 1 (NEK1) constitute a major genetic cause of amyotrophic lateral sclerosis (ALS), accounting for 2 to 3% of all cases. " 01/01/2023 - "NIMA-related kinase 1(NEK1) gene was related to amyotrophic lateral sclerosis (ALS). " 04/01/2021 - "Recently, NEK1 (NIMA-related kinase 1) mutations were identified as a cause of amyotrophic lateral sclerosis (ALS), but the relationship between them remains unclear owing to the small sample size and low mutation rate. " 01/01/2023 - "The NEK1 kinase controls ciliogenesis, mitosis, and DNA repair, and NEK1 mutations cause human diseases including axial spondylometaphyseal dysplasia and amyotrophic lateral sclerosis. "
2.	Chromosomal Instability (Chromosome Stability) 01/10/2011 - "Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability."
3.	Sarcoma (Soft Tissue Sarcoma) 01/01/2023 - "Established pathogenic variants include superoxide dismutase type 1 (SOD1), chromosome 9 open reading frame 72 (c9orf72), TAR DNA Binding Protein (TARDBP), and Fused In Sarcoma (FUS); additional ALS-related genes including Charged Multivesicular Body Protein 2B (CHMP2B), Senataxin (SETX), Sequestosome 1 (SQSTM1), TANK Binding Kinase 1 (TBK1) and NIMA Related Kinase 1 (NEK1), have been identified. "
4.	Neoplasms (Cancer) 12/01/2019 - "Both Von Hippel-Lindau tumor suppressor (VHL) and Never-in-mitosis A (NIMA)-related kinase 1 (NEK1) are involved in primary cilium formation, but whether VHL could regulate NEK1 is unknown. "
5.	Polycystic Kidney Diseases (Polycystic Kidney Disease) 06/04/2008 - "Mutations in Nek1 (NIMA-Related Kinase 1) are causal in the murine models of polycystic kidney disease kat and kat2J. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tubulin
3.	Superoxide Dismutase
4.	Phosphotransferases (Kinase)
5.	DNA-Binding Proteins (DNA Binding Protein)