SEC Translocation Channels

Universally conserved multiprotein complexes that form the protein transport channel of the general secretory (SEC) pathway. The SEC translocase is present in all bacteria, archaea, and eukaryotes. It is in the ENDOPLASMIC RETICULUM membrane of eukaryotic cells, in the THYLAKOID MEMBRANE in CHLOROPLASTS and in some protozoa in the INNER MITOCHONDRIAL MEMBRANE.

Also Known As:

SEC Complexes; SEC Translocase; SEC Translocons; SEC61 Protein; SEC61 Proteins; SEC61 Translocase; SEC61 Translocation Channels; SEC61 Translocon; Sec Protein Translocation Systems; Sec61 Complex; Sec61 Protein Translocation System; SecY Translocase; SecYEG Complex; SecYEG Complexes; SecYEG Protein Translocation System; SecYEG Proteins; SecYEG Translocation Channels; SecYEG Translocon; Channel, SEC Translocation; Channel, SEC61 Translocation; Channel, SecYEG Translocation; Channels, SEC Translocation; Channels, SEC61 Translocation; Channels, SecYEG Translocation; Complex, Sec61; Complex, SecYEG; Complexes, SEC; Complexes, SecYEG; Protein, SEC61; Protein, SecYEG; Proteins, SEC61; Proteins, SecYEG; Translocase, SEC; Translocase, SEC61; Translocase, SecY; Translocation Channel, SEC; Translocation Channel, SEC61; Translocation Channel, SecYEG; Translocation Channels, SEC; Translocation Channels, SEC61; Translocation Channels, SecYEG; Translocon, SEC; Translocon, SEC61; Translocon, SecYEG; Translocons, SEC; SEC Translocation Channel; SEC Translocon; SEC61 Translocation Channel; Sec Protein Translocation System; SecYEG Protein; SecYEG Translocation Channel

Networked: 23 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Demangel, Caroline: 2 articles (01/2022 - 10/2020)
2.	Li, Xin: 2 articles (01/2022 - 01/2021)
3.	Song, Yongcheng: 2 articles (01/2022 - 01/2021)
4.	Wu, Fangrui: 2 articles (01/2022 - 01/2021)
5.	Yao, Yuan: 2 articles (01/2022 - 01/2021)
6.	Liang, Yibo: 1 article (04/2022)
7.	Shi, Yanan: 1 article (04/2022)
8.	Wang, Wei: 1 article (04/2022)
9.	Zhang, Guimin: 1 article (04/2022)
10.	Arnulf, Bertrand: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "This uniquely potent inhibitor of the mammalian translocon (Sec61) helped reveal the central importance of Sec61 activity for immune cell functions, the spread of viral particles and, unexpectedly, the viability of certain cancer cells. " 01/01/2021 - "While the open Sec61 complex forms an aqueous polypeptide-conducting- and transiently Ca2+-permeable channel, the closed complex is impermeable even to Ca2+. Therefore, we discuss the human hereditary and tumor diseases that are linked to Sec61 channel gating, termed Sec61-channelopathies, as disturbances of selective polypeptide-impermeability and/or aberrant Ca2+-permeability." 04/01/2022 - "Based on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches. " 01/01/2022 - "Finally, we will explore the relevance of the Sec61 complex as a Ca2+-leak channel in various pathophysiological (ER stress, apoptosis, ischemia-reperfusion) and pathological (type 2 diabetes, cancer) settings." 01/01/2021 - "Background: Overexpression of the membrane protein SEC61 translocon gamma subunit (SEC61G) has been observed in a variety of cancers; however, its role in head and neck squamous cell carcinomas (HNSCC) is unknown. "
2.	Kidney Neoplasms (Kidney Cancer) 01/01/2021 - "The present study aimed to investigate the role of SEC61 translocon subunit‑γ (SEC61G) in kidney cancer. "
3.	Colonic Neoplasms (Colon Cancer) 02/24/2021 - "Previous studies revealed that SEC61 translocon alpha 1 subunit1 (SEC61A) can act as an oncogene in colon adenocarcinoma. "
4.	Squamous Cell Carcinoma of Head and Neck 10/01/2023 - "Among the SEC61 complex genes, only SEC61G upregulation is consistently associated with unfavorable progression-free interval and disease-specific survival in patients with HNSCC. " 10/01/2023 - "High SEC61 translocon subunit gamma (SEC61G) expression is associated with an unfavorable prognosis in patients with head and neck squamous cell carcinoma (HNSCC), but the underlying mechanisms remain poorly understood. " 10/01/2023 - "SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca2+-mediated autophagy." 04/01/2022 - "Based on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches. " 01/01/2021 - "Background: Overexpression of the membrane protein SEC61 translocon gamma subunit (SEC61G) has been observed in a variety of cancers; however, its role in head and neck squamous cell carcinomas (HNSCC) is unknown. "
5.	Carcinogenesis 04/01/2022 - "Based on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches. " 01/01/2022 - "Most frequent MLL1-fusion partners AF4/AFF4, AF9/ENL and ELL, together with CDK9/cyclin-T1, constitute super elongation complexes (SEC), which promote aberrant gene transcription, oncogenesis and maintenance of MLL1-rearranged (MLL1-r) leukemia. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Membrane Proteins (Integral Membrane Proteins)
3.	coibamide A
4.	Cyclin T
5.	Depsipeptides
6.	Signal Recognition Particle
7.	Cytokines
8.	Peptides (Polypeptides)
9.	Exotoxins
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Therapeutics