Cyclin T

A cyclin subtype that is found associated with CYCLIN-DEPENDENT KINASE 9. Unlike traditional cyclins, which regulate the CELL CYCLE, type T cyclins appear to regulate transcription and are components of positive transcriptional elongation factor B.

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Networked: 38 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Goldstein, Harris: 4 articles (01/2016 - 11/2009)
2.	Rice, Andrew P: 4 articles (01/2013 - 08/2004)
3.	Zheng, Jian Hua: 3 articles (01/2016 - 11/2009)
4.	Liou, Li-Ying: 3 articles (02/2006 - 08/2004)
5.	Herrmann, Christine H: 3 articles (02/2006 - 08/2004)
6.	Seay, Kieran: 2 articles (01/2016 - 09/2015)
7.	Ochsenbauer, Christina: 2 articles (01/2016 - 09/2015)
8.	Kappes, John C: 2 articles (01/2016 - 09/2015)
9.	Dutta, Monica: 2 articles (02/2014 - 11/2009)
10.	Saifuddin, Mohammed: 2 articles (11/2009 - 01/2009)

Related Diseases

1.	Infection 01/01/2009 - "Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo." 01/01/2016 - "The second model, hCD4/R5/cT1 mice, consists of transgenic mice carrying human CD4, CCR5 and cyclin T1 genes, which enables murine CD4-expressing cells to support HIV-1 entry, Tat-mediated LTR transcription and consequently develop productive infection. " 09/01/2015 - "To investigate whether HSV-2 infection directly facilitates mucosal HIV-1 acquisition, we used our transgenic hCD4/R5/cT1 mouse model which circumvents major entry and transcription blocks preventing murine HIV-1 infection by targeting transgenic expression of human CD4, CCR5, and cyclin T1 genes to CD4(+) T cells and myeloid-committed cells. " 01/01/2015 - "Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection." 01/01/2013 - "We find that resting CD4(+) T cells, whether naïve or memory and independent of their infection status, have low levels of Cyclin T1 and T-loop-phosphorylated CDK9, which increase upon activation. "
2.	HIV Infections (HIV Infection) 11/01/2009 - "This study provides evidence that HIV infection of cells occurs in the vagina of mice expressing human CD4, CCR5, and Cyclin T1 and that HSV-2 infection increases HIV infection. " 02/01/2006 - "Cyclin T1 can be reinduced by pathogen-associated molecular patterns (PAMPs) or HIV infection. "
3.	Neoplasms (Cancer) 08/01/2010 - "injected with stable transfected Cyclin T1 cells (NIH 3T3 Cyclin T1) developed tumors faster than animals injected with control cells (NIH 3T3 beta-gal). " 08/01/2010 - "Cyclin T1 overexpression induces malignant transformation and tumor growth." 05/01/2008 - "The CDK9/cyclin T1 complex is expressed at higher level in more differentiated primary neuroectodermal and neuroblastoma tumors, showing a correlation between the kinase expression and tumor differentiation grade. " 03/01/2004 - "Flavopiridol exerts multiple effects in tumor cells, including inhibition of multiple CDKs, transcriptional inhibition secondary to disruption of P-TEFb (CDK9/cyclin T), induction of apoptosis, and antiangiogenesis. " 03/01/2005 - "In addition, the expression of Cdk9 and Cyclin T1 was evaluated by immunohistochemistry in samples of neuroblastoma, PNET (Primary Neuroectodermal Tumor) and astrocytoma tumors of different grades, in order to assess whether there was a correlation between Cdk9 expression and tumor grading. "
4.	Cardiomegaly (Heart Hypertrophy) 01/01/2006 - "Specifically, the activity of the cyclin T1/CDK9 complex is essential for HIV-1 replication and CDK9 upregulation is associated with cardiac hypertrophy. " 01/01/2004 - "Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9." 10/03/2008 - "The positive transcription elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 and cyclin T1, stimulates the elongation of transcription by hyperphosphorylating the C-terminal region of RNA polymerase II. Aberrant activation of P-TEFb results in manifestations of cardiac hypertrophy in mice, suggesting that P-TEFb is an essential factor for cardiac myocyte function and development. " 02/06/2004 - "The positive transcription elongation factor b (P-TEFb), comprising CDK9 and cyclin T, stimulates transcription of cellular and viral genes by phosphorylating RNA polymerase II. A major portion of nuclear P-TEFb is sequestered and inactivated by the coordinated actions of the 7SK snRNA and the HEXIM1 protein, whose induced dissociation from P-TEFb is crucial for stress-induced transcription and pathogenesis of cardiac hypertrophy. " 02/14/2013 - "Cyclin-dependent kinase 9/cyclin T, the protein kinase heterodimer that constitutes positive transcription elongation factor b, is a well-validated target for treatment of several diseases, including cancer and cardiac hypertrophy. "
5.	Osteosarcoma (Osteogenic Sarcoma) 04/01/2000 - "The murine cells supported reverse transcription and integration at levels comparable to those in the human osteosarcoma-derived cell line GHOST.R5, and human cyclin T1 restored provirus expression, consistent with earlier findings of others. " 03/01/2000 - "Here we present the cloning of Cyclin T1 from canine D17 osteosarcoma cells, which support EIAV transactivation, and show that canine Cyclin T1 confers eTat transactivation to human cells. " 01/01/2011 - "Within minutes after the incubation of human osteosarcoma U2OS cells with 5μm DRAQ5, the distributions of RNA polymerase II and some of its associated regulatory proteins HEXIM and cyclin T1 in the nucleus are severely impaired, and transcription is inhibited. "

Related Drugs and Biologics

1.	Positive Transcriptional Elongation Factor B
2.	RNA Polymerase II (RNA Polymerase B)
3.	Cyclin-Dependent Kinase 9
4.	Cyclin T
5.	Proteins (Proteins, Gene)
6.	Phosphotransferases (Kinase)
7.	Cyclin H
8.	Gq-G11 GTP-Binding Protein alpha Subunits (Gq Protein)
9.	MicroRNAs (MicroRNA)
10.	Small Interfering RNA (siRNA)