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flurbiprofen benzyl nitrate

structure in first source

Also Known As:

NBS-242

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jacobs, Lloydine: 1 article (01/2013)
2.	Kashfi, Khosrow: 1 article (01/2013)
3.	Liu, Xiaoping: 1 article (01/2013)
4.	Nath, Niharika: 1 article (01/2013)

Related Diseases

1.	Skin Neoplasms (Skin Cancer) 01/01/2013 - "We synthesized an NO-releasing NSAID with an aromatic spacer (flurbiprofen benzyl nitrate, NBS-242), and using the human skin cancer cell line A-431, we evaluated its effects on cell kinetics, Wnt/β-catenin, cyclin D1, and caspase-3. "
2.	Neoplasms (Cancer) 01/01/2013 - "NBS-242 inhibited the growth of A-431 cancer cells, being ~15-fold more potent than flurbiprofen and up to 5-fold more potent than NO-flurbiprofen with an aliphatic spacer, the half maximal inhibitory concentrations (IC50) for growth inhibition being 60 ± 4 μM, 320 ± 20 μM, and 880 ± 65 μM for NBS-242, NO-flurbiprofen, and flurbiprofen, respectively. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2013 - "These findings establish a strong inhibitory effect of NBS-242 in A-431 human epidermoid carcinoma cells. " 01/01/2013 - "Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin."

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Catenins
3.	Cyclin D1
4.	Flurbiprofen (Froben)
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)