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Flurbiprofen (Froben)

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An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.

Also Known As:

Froben; Ansaid; Ocufen; 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid; Abbott Brand of Flurbiprofen; Allergan Brand of Flurbiprofen Sodium; Apo-Flurbiprofen; Apotex Brand of Flurbiprofen; BTS-18322; Cantabria Brand of Flurbiprofen; Cebutid; Crookes Brand of Flurbiprofen; Dobrofen; E-7869; Flubiprofen; Flugalin; Flurbiprofen Sodium; Fluriproben; Froben SR; Klosterfrau Brand of Flurbiprofen; Knoll Brand of Flurbiprofen; Neo Artrol; Novo-Flurprofen; Novopharm Brand of Flurbiprofen; Nu-Flurbiprofen; Nu-Pharm Brand of Flurbiprofen; Ocuflur; Pfizer Brand of Flurbiprofen; Pharm-Allergan Brand of Flurbiprofen Sodium; Ratiopharm Brand of Flurbiprofen; Recordati Brand of Flurbiprofen; Shire Brand of Flurbiprofen; Strefen; ratio-Flurbiprofen; Apo Flurbiprofen; BTS 18322; BTS18322; E 7869; E7869; Flurbiprofen Pfizer Brand; Novo Flurprofen; Nu Flurbiprofen; Nu Pharm Brand of Flurbiprofen; Pharm Allergan Brand of Flurbiprofen Sodium; Sodium, Flurbiprofen; ratio Flurbiprofen; (1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-

Networked: 623 relevant articles (90 outcomes, 151 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Aromatic Hydrocarbons: 132
      - Benzene Derivatives: 13
        Biphenyl Compounds: 5
        Flurbiprofen: 623
        flurbiprofen axetil: 38
        nitroflurbiprofen: 20
        1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid: 15
        flurizan: 11
        (3-4-(2-fluoromethyl-(1,1'-biphenyl)-4-acetyloxy)-3-methoxyphenyl)-2-propenoic acid 4-nitrooxy butyl ester: 4
        strepfen: 3
        copper flurbiprofen complex: 1
        flurbiprofen N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-2-(2-hydroxyethylthio)acetamide: 1
        HCT1027: 1
        2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid 4-(nitro-oxy)butyl ester
        3',4'-dihydroxyflurbiprofen
        3'-hydroxy-4'-methoxyflurbiprofen
        4'-hydroxyflurbiprofen
        CHF 5022
- Carboxylic Acids: 83
  - Acyclic Acids
    - Propionates: 4
      - Propionic Acids: 9
        Flurbiprofen: 623
        flurbiprofen axetil: 38
        nitroflurbiprofen: 20
        1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid: 15
        flurizan: 11
        (3-4-(2-fluoromethyl-(1,1'-biphenyl)-4-acetyloxy)-3-methoxyphenyl)-2-propenoic acid 4-nitrooxy butyl ester: 4
        strepfen: 3
        copper flurbiprofen complex: 1
        flurbiprofen N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-2-(2-hydroxyethylthio)acetamide: 1
        HCT1027: 1
        2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid 4-(nitro-oxy)butyl ester
        3',4'-dihydroxyflurbiprofen
        3'-hydroxy-4'-methoxyflurbiprofen
        4'-hydroxyflurbiprofen
        CHF 5022

Experts

1.	Geisslinger, Gerd: 4 articles (11/2014 - 07/2003)
2.	Tegeder, Irmgard: 4 articles (11/2014 - 07/2003)
3.	Fujii, Yoshitaka: 4 articles (04/2009 - 01/2004)
4.	Del Soldato, P: 4 articles (09/2004 - 09/2001)
5.	Bishay, Philipp: 3 articles (11/2014 - 01/2010)
6.	Häussler, Annett: 3 articles (11/2014 - 01/2010)
7.	Shephard, Adrian: 3 articles (02/2014 - 02/2013)
8.	Chen, Yao: 3 articles (12/2013 - 05/2013)
9.	Sun, Jianfei: 3 articles (12/2013 - 05/2013)
10.	Lehmann, Jochen: 3 articles (12/2013 - 05/2013)

Related Diseases

1.	Pain (Aches) 03/24/1986 - "Using the highly sensitive dental pain model, flurbiprofen appears to be an effective, peripherally acting analgesic with a rapid onset of activity. " 03/01/2002 - "The efficacy of flurbiprofen 8.75 mg lozenge over placebo was confirmed: there was a significant difference in pain relief obtained from flurbiprofen 8.75 mg versus placebo, along with a significant reduction of difficulty in swallowing from the time of first assessment and significantly greater reductions in throat soreness and difficulty in swallowing throughout the study period. " 04/10/2014 - "Flurbiprofen in 15 mg/kg and 40 mg/kg doses significantly improved pain tolerance measured by tail flick test (tail flick in FBP15 and FBP40 groups: 96.hour vs 97.hour, 7.01±4.97 vs 8.34±3.61 and 5.06±1.57 vs 7.04±2.49, p<0.05 for both). " 02/01/2013 - "A significant reduction in pain intensity was found in both groups; the average visual analog scale (VAS) score was reduced from 7.8 to 3.0 in the control group and from 7.9 to 2.2 in the flurbiprofen group (P<0.01). " 01/01/1994 - "On day 7, spontaneous pain (the prime efficacy parameter), as evaluated by the patient on a visual analogue scale in the physician's office, showed significant improvement in the 40 mg flurbiprofen patch group compared to control (change from baseline) (p = 0.039), a result corroborated by the evaluation of the periarticular oedema: a reduction of 77.4% was observed in the 40 mg flurbiprofen patch group, compared with 63.8% in the control group (p = 0.025). "
2.	Cataract (Cataracts) 03/01/1991 - "The data of this study indicate that flurbiprofen ophthalmic solution is effective in protecting the blood aqueous barrier (BAB) in human eyes during cataract surgery and IOL implantation." 12/15/1998 - "Cost-effectiveness of topical 0.03% flurbiprofen in outpatient cataract surgery as measured by surgical time and vitreous loss." 10/01/1992 - "The pupillary area available for surgical manipulation in the control group was significantly decreased from 56.18 mm2 in state I to 9.94 mm2 in stage III, while in flurbiprofen group it changed insignificantly from 58.05 mm2 in stage I to 50.24 mm2 in stage III. Postoperatively after cataract was observed in 44% eyes of control group as compared to only 8% of eyes of flurbiprofen group. " 08/01/1990 - "Effect of flurbiprofen on the maintenance of pupillary dilation during cataract surgery." 07/01/1989 - "Ocufen and pupillary dilation during cataract surgery."
3.	Postoperative Pain 03/24/1986 - "Data also suggest that flurbiprofen administered 30 minutes before surgery reduced the severity of postoperative pain. " 01/01/2009 - "Randomised, double blind, placebo-controlled trials of single dose orally administered flurbiprofen in adults with moderate to severe acute postoperative pain. " 02/01/2015 - "PNB+iv-PCA decreased the rate of administration of flurbiprofen as compared to PCEA for postoperative pain after peritonectomy." 01/01/2012 - "Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to control moderate postoperative pain and is not associated with respiratory inhibition. " 01/01/2009 - "Flurbiprofen at doses of 50 mg and 100 mg is an effective analgesic in moderate to severe acute postoperative pain. "
4.	Osteoarthritis 05/01/1988 - "This study confirms the good efficacy and tolerability of flurbiprofen in the symptomatic relief of osteoarthritis." 01/01/1986 - "A long-term study of flurbiprofen in rheumatological disorders: II. Osteoarthrosis." 10/01/1985 - "Open study of flurbiprofen in the treatment of osteoarthritis of the knee." 03/24/1986 - "In patients with rheumatoid arthritis, osteoarthritis, and numerous other inflammatory disorders, 100 to 200 mg of flurbiprofen in two to four divided doses has led to significant clinical improvement. " 10/01/1992 - "A six week, double-blind, randomized, parallel group, multicentre study was conducted in 85 patients with osteoarthritis of the knee and hip to compare the efficacy, tolerability, and safety of Flurbiprofen-SR 200 mg with Diclofenac Sodium-SR 100 mg. Between group comparisons, based on change scores from baseline, we detected no significant differences between the two drugs with respect to efficacy for the majority of outcome measures. "
5.	Inflammation 12/01/1998 - "Intestinal inflammation was significantly greater following administration of (S)-flurbiprofen and racemate than with dinitrophenol and (R)-flurbiprofen. " 07/01/1993 - "Flurbiprofen provided postsurgical anti-inflammatory efficacy in clinical signs of inflammation and in blood-aqueous barrier disruption, and also showed improved subjective signs." 04/01/2007 - "The objective of the study was to design and evaluate NSAID loaded Nanoparticles drug delivery system, where Flurbiprofen (model drug) Nanoparticles with suitable size range are envisaged to concentrate at inflammation sites due to increase fragility of blood vessels at those sites and increased aggregation and prostaglandin synthesis. " 06/01/1999 - "The test (flurbiprofen-containing) formulation significantly reduced gingival inflammation, as evaluated using the gingival index, and the gingival crevicular fluid volume, whereas, these clinical parameters were generally increased in volunteers who had received the control formulation. " 11/01/1995 - "Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation."

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Diclofenac (SR 38)
3.	Flurbiprofen (Froben)
4.	Aspirin (Acetylsalicylic Acid)
5.	Naproxen (Naprosyn)
6.	Acetaminophen (Paracetamol)
7.	Piroxicam (Feldene)
8.	Lidocaine (Xylocaine)
9.	Morphine (MS Contin)
10.	Propofol (Diprivan)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Cataract Extraction
4.	Intraocular Lens Implantation
5.	Angioplasty (Angioplasty, Transluminal)