Skin Neoplasms (Skin Cancer)

05/27/2015 - "The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. "
07/01/2006 - "The study suggests that 5-ALA PDT is effective in the treatment of superficial skin cancer and premalignant lesions."
12/01/2011 - "Because of these benefits, PDT is being evaluated as a potential treatment option for many dermatologic conditions and has been shown to be effective for certain nonmelanoma skin cancers. "
12/01/2010 - "Photosensitizer Radachlorin®: Skin cancer PDT phase II clinical trials."
05/01/2010 - "Additional studies with larger numbers of patients and optimized protocols are necessary to further explore the potential benefits of cyclic PDT in the prevention of skin cancer in this high-risk patient population."

08/01/2009 - "As sunscreens do not provide complete protection against solar/UV radiation, alternative protective strategies are necessary to cope with the increasing incidence of skin cancer. "
07/01/1981 - "Prevention of long-term UVR effects on skin is a desirable goal; development of personal UVR dosimeters will aid in defining the quantitative nature of the problem; improved sunscreens should provide the means to achieve significant reduction in the incidence of UVR-induced human skin cancer."
01/01/2003 - "Sunscreens are widely advocated to protect against skin cancer but if they offer insufficient protection against immunosuppression they may inadvertently increase skin cancer risk. "
11/01/2005 - "This article reviews the efficacy of sunscreens in the prevention of epithelial and nonepithelial skin cancer, the effect on immunosuppression and the value of the SPF as well as new developments on the sunscreen market."
12/01/2007 - "Targeting mutant p53 shows promise for sunscreens and skin cancer."

07/01/2008 - "Complete remission was observed after 6 to 10 weeks of imiquimod 5% (10 mg/cm of skin cancer) treatment. "
08/15/2011 - "Imiquimod is a TLR7/8 agonist that has anticancer therapeutic efficacy in the treatment of precancerous skin lesions and certain nonmelanoma skin cancers. "
05/01/2004 - "Imiquimod has been shown to stimulate the cutaneous immune response and be effective for the treatment of nonmelanoma skin cancers. "
01/01/2006 - "Imiquimod, a topical immunomodulator, approved its efficiency in several skin neoplasms and has been shown as a safe treatment for EMPD. "
01/01/2014 - "This observational study shall show that nonmelanoma skin cancer can be detected at its earliest subclinical stage by its reaction with imiquimod and can be cleared by finishing the course of treatment. "

10/01/2014 - "Further research is needed to investigate the effect of vitamin D on skin cancer risk in populations with different exposure to sunlight and dietary habits, and to evaluate whether vitamin D supplementation is effective in improving CM survival. "
06/01/2014 - "Vitamin D modulation of the cell cycle, DNA repair and apoptosis via its receptors (VDRs) may have a suppressive effect on skin cancer as some studies suggest. "
03/01/2013 - "Studies also suggest that, with decreased sun exposure due to concern for skin cancer risk, much of the world's population is becoming increasingly deficient in vitamin D. "
11/01/2012 - "The objective of this study was to evaluate the effect of reduced sun exposure of outdoor workers on vitamin D status using different modalities of sun protection, for primary prevention of skin cancer. "
11/01/2012 - "With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar risk reducing effect. "

12/01/2002 - "Review of the literature demonstrates that the administration of synthetic retinoids has not proved beneficial for otherwise healthy patients with nonmelanoma skin cancer. "
12/01/2005 - "A majority of the studies found a decrease in the number of malignant and pre-malignant cutaneous lesions in patients treated with systemic retinoids, with several studies noting increased benefit in those patients with multiple previous skin cancers. "
03/01/2002 - "This review focuses on the retinoids and details their results in clinical trials for treatment and prevention of skin cancer. "
03/19/1997 - "The effect of retinoids had no significant benefit on squamous or basal cell skin cancers in the high risk subjects on the SKICAP-S/B trial, although intervention duration was less than planned. "
01/01/1991 - "Evidence from clinical studies suggests that although topical retinoids have some effect in treating established skin cancers, alternative treatments are more effective. "

06/01/1985 - "Statistical analyses revealed significant dose-dependent selenium-mediated protection against UV-light-induced skin cancer. "
12/01/1990 - "An application is described to a large ongoing randomized controlled clinical trial for the efficacy of nutritional supplements of selenium for the prevention of two types of skin cancer."
02/18/2004 - "Re: Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial."
10/01/2003 - "Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial."
12/01/2002 - "Selenium supplementation has reduced the incidence of several internal malignancies but not of nonmelanoma skin cancer. "

09/01/2012 - "These results suggest that silibinin may be beneficial in the removal of UVA-damaged cells and the prevention of skin cancer."
09/01/2005 - "Overall, the protective efficacy of silibinin against skin cancer is supported by sound mechanistic rationale in animal and cell culture studies, and suggests its potential use for humans."
09/01/2005 - "Mechanisms and preclinical efficacy of silibinin in preventing skin cancer."
05/27/2005 - "Together, these findings suggest that silibinin preferentially activates the DNA-PK-p53 pathway for apoptosis in response to UVB-induced DNA damage, and that this could be a predominant mechanism of silibinin efficacy against UVB-induced skin cancer."
11/24/2015 - "Together, these findings suggest that silibinin's efficacy against UVB-induced photodamage is primarily by inhibiting NER and p53; and these findings further support silibinin's usage as a potential inexpensive, effective, and non-toxic agent for skin cancer chemoprevention. "

07/01/1981 - "Preliminary studies with oral 13-cis-retinoic acid have not demonstrated any effects to date on UV-induced skin cancer formation."
01/01/2011 - "Exclusion criteria for treatment were suspicion of skin cancer, isotretinoin treatment during the previous 6 months, and pregnancy. "
01/01/2005 - "A combination of systemic isotretinoin and interferon-alpha-2a may provide a more potent effect than isotretinoin alone in the prevention and treatment of skin cancers.Systemic"
09/01/2004 - "High-dose isotretinoin has mainly been utilized in those patients at high-risk for multiple new skin cancers where the risk of morbidity from side effects is overshadowed by the benefit to the patient."
03/04/1992 - "High-dose isotretinoin has been reported to have a prophylactic effect on nonmelanoma skin cancer, although it is associated with significant toxicity. "

01/01/2009 - "Melanin pigments provide efficient protection against ultraviolet B (UVB) radiation but DNA repair also plays a key role in eliminating UV-induced damage and preventing the development of skin cancers. "
10/01/2010 - "Conventional wisdom has it that the incidence of all varieties of skin cancers is lower among Indians due to the protective effects of melanin. "
04/01/1989 - "There appeared to be an overrepresentation of types I and II. Increased melanin pigmentation may therefore be either directly or indirectly protective against the development of skin cancers in patients who have received low-dose superficial ionizing radiation for benign disease. "
10/01/2002 - "Ultimately, the genetic and chemical assessment of melanin synthesis rather than skin colour will be the best indicator for skin cancer risk, and such genetic association studies combined with functional analysis of variant alleles should provide the link to understanding skin phototypes."
01/01/2015 - "Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. "

11/01/1997 - "We conducted a randomized, double-blind, controlled trial to examine the efficacy of retinol supplementation on the incidence of first new nonmelanoma skin cancer in moderate-risk subjects. "
06/01/2009 - "Efficacy of vitamin A as a chemopreventive agent for skin cancer could be demonstrated with a dose-response curve after a second-order discriminant analysis was employed. "
11/01/1997 - "Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. "
10/01/2003 - "A major risk factor for skin cancer is UV irradiation, which not only damages DNA and other photosensitive compounds like vitamin A, but may also perturb cellular signaling, e.g. "
11/20/1999 - "[Vitamin A as an antidote against skin cancer?]."

04/01/1993 - "Photodynamic therapy is a modality that potentially could be most helpful in treating multicentric skin cancers. "
12/01/2000 - "These observations may be important for improving the efficacy of photodynamic therapy for the treatment of skin cancer and possibly other skin disorders. "
05/01/2011 - "This approach can be effective for the treatment of skin cancer by topical photodynamic therapy."
03/01/2003 - "It remains to be seen whether this enhanced local bioavailability of the protoporphyrin prodrug can allow improved photodynamic therapy for the treatment of skin cancer."
07/09/2008 - "The potential of these photosensitive nitrosyl-dye conjugates as (i) biological tools to study the effects of NO in cellular environments and (ii) "trackable" NO donors in photodynamic therapy of malignancies (such as skin cancer) has been discussed."

01/01/2014 - "Till date several phytochemicals in the light of chemoprevention have been studied by using suitable skin carcinogenic in vitro and in vivo models and proven as beneficial for prevention of skin cancer. "
10/01/2003 - "The total histologic score, having demonstrated reliability on repeated readings and validity in its association with biopsy location and histologic score, is a reliable and valid end point for judging the efficacy of agents in skin cancer chemoprevention studies. "
05/01/2001 - "The efficacy of systemic retinoid skin cancer chemoprevention was first demonstrated in these disorders. "
01/01/2014 - "New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals: In Vitro and In Vivo Studies and the Underlying Mechanisms."
12/01/2012 - "A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity."

05/01/2013 - "Survival analysis showed significant reduction in the time to develop skin cancer in patients transplanted from 1995 onwards (P < 0.0001) and in patients who had been on triple immunosuppressant therapy at 1 year after transplant, compared with dual therapy (P < 0.0001). "
06/01/2006 - "Systemic retinoid therapy is thought to be beneficial for chemosuppression of skin cancers in solid organ transplant recipients. "
06/01/2006 - "To determine whether an intensive educational program focused on the risk of skin cancer in organ transplant recipients, a population at high risk for development of skin cancer because of immunosuppression, produced measurable improvement in patient knowledge and sun-protective behavior. "
03/01/2013 - "Thus, the adjuvant strategy of modifying immunosuppression may be effective when confronting severe transplant-associated skin cancer. "
12/01/2007 - "Although evidence supports the efficacy of reducing immunosuppression for transplant-associated skin cancer, clinical thresholds for and risks associated with reduction are not well defined. "

07/01/2012 - " Mohs surgery may be your best option for nonmelanoma skin cancers."
03/01/2014 - "Mohs Micrographic Surgery (MMS) is the current 'gold-standard' for excision of a number of cutaneous lesions and provides a valuable addition to a skin cancer service. "
07/01/2014 - "Mohs micrographic surgery (MMS) is an effective treatment for skin cancer. "
09/01/2012 - "  Mohs micrographic surgery (MMS) is regarded as the gold standard for treating nonmelanoma skin cancers of the head and neck. "
04/01/2011 - "Mohs micrographic surgery (MMS) has become the gold standard for treating many forms of primary and recurrent contiguous skin cancers and offers the highest cure rates and maximum tissue conservation compared with other modalities. "

05/01/2015 - "Conventionally fractionated radiotherapy is effective for local control and provides excellent cosmesis for elderly patients with skin cancer of the head."
06/01/2005 - "The results obtained confirm the possibility of treating epithelial skin neoplasms of the pinna with dermatologic radiotherapy, which can afford high-remission percentages without damaging cartilaginous tissue."
11/01/2001 - "Radiotherapy alone results in a relatively high probability of cure for selected patients with T4 skin cancers."
01/01/2002 - "After 100 years of treatment of skin cancers by radiotherapy, dermatologists should not forget that if appropriate principles are followed and precautions are taken, X-ray treatment is still a safe and effective method."
01/01/2015 - "Although surgery is usually the first-line treatment for nonmelanoma skin cancers, radiotherapy (RT) may be indicated in selected cases. "