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A-995662

a selective TRPV1 receptor antagonist; structure in first source

Also Known As:

(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        A-995662: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - A-995662: 1

Experts

1.	Baker, Scott J: 1 article (08/2010)
2.	Bianchi, Bruce R: 1 article (08/2010)
3.	Faltynek, Connie R: 1 article (08/2010)
4.	Gauvin, Donna M: 1 article (08/2010)
5.	Han, Ping: 1 article (08/2010)
6.	Honore, Prisca: 1 article (08/2010)
7.	Joshi, Shailen K: 1 article (08/2010)
8.	Koenig, John R: 1 article (08/2010)
9.	Kort, Michael E: 1 article (08/2010)
10.	Kym, Philip R: 1 article (08/2010)

Related Diseases

1.

08/01/2010 - "The TRPV1 antagonist A-995662 demonstrates analgesic efficacy in monoiodoacetate-induced osteoarthritic (OA) pain in rat, and repeated dosing results in increased in vivo potency and a prolonged duration of action. "
08/01/2010 - "A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model."

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Analgesics (Analgesic Drugs)
3.	TRPV1 receptor