cytochrome P-450 CYP1A3 (rainbow trout)

from rainbow trout (Oncorhynchus mykiss); has 7-ethoxyresorufin, methoxyresorufin and phenacetin O-dealkylase activity; N-terminal amino acid sequence has been determined

Also Known As:

CYP1A3; cytochrome P-450 CYP1A3

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Aryl Hydrocarbon Hydroxylases: 18
        cytochrome P-450 CYP1A3 (rainbow trout): 3
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Aryl Hydrocarbon Hydroxylases: 18
      - cytochrome P-450 CYP1A3 (rainbow trout): 3
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Aryl Hydrocarbon Hydroxylases: 18
        cytochrome P-450 CYP1A3 (rainbow trout): 3

Experts

1.	Elphick, James R: 1 article (04/2016)
2.	Kennedy, Chris J: 1 article (04/2016)
3.	Marlatt, Vicki L: 1 article (04/2016)
4.	Martyniuk, Christopher J: 1 article (04/2016)
5.	Sherrard, Ryan: 1 article (04/2016)
6.	Aiken,: 1 article (05/2000)
7.	Cao,: 1 article (05/2000)
8.	Hong,: 1 article (05/2000)
9.	Peterson,: 1 article (05/2000)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 05/01/2000 - "In rainbow trout gonad (RTG)-2 and rainbow trout hepatoma (RTH)-149 cell lines, CYP1A1 was constitutively expressed and induced by exposure to TCDD, but CYP1A3 message was not detected, even after TCDD treatment. " 03/01/1999 - "Five putative AHREs were found between -451 and -1820, with an overlap of AHRE3 and AHRE4 sharing 1 bp. The 5' flanking region of the trout CYP1A3 gene was fused to the firefly luciferase (luc) reporter gene and transiently transfected into mouse hepatoma Hepa-1c1c7 wild-type (wt) cell cultures and three benzo[a]pyrene-resistant mutant lines: c2, containing less than 10% levels of functional AHR; c4, defective in ARNT; and c37, deficient in CYP1A1 metabolism. "
2.	Congenital Abnormalities (Deformity) 04/01/2016 - "The endpoints measured in swim-up fry included survival, deformities, growth (weight and length), vitellogenin (vtg) and metallothionein (Mt) protein levels, and hepatic gene expression (e.g., metallothioneins [mta and mtb], endocrine biomarkers [vtg and estrogen receptors, esr] and xenobiotic-metabolizing enzymes [cytochrome P450 1A3, cyp1a3 and glutathione transferases, gstk]). "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A1 (CYP1A1)
2.	Firefly Luciferases
3.	Biomarkers (Surrogate Marker)
4.	Xenobiotics
5.	Vitellogenins (Vitellogenin)
6.	Estrogen Receptors
7.	Proteins (Proteins, Gene)
8.	Metallothionein
9.	Glutathione Transferase (Glutathione S-Transferase)
10.	Enzymes