bretylium

01/01/1987 - "This study was performed to assess the role of cardiac sympathetic nerves in the in vivo antifibrillatory action of bretylium using the technique of electrically induced ventricular fibrillation. "
06/01/1993 - "Since the use of bretylium was instituted, there have been no cases of ventricular fibrillation in a series of 20 animals. "
01/01/1989 - "In the unusual case reported here, the patient's temperature reached 42.3 degrees C (108.2 degrees F) during intravenous administration of bretylium for refractory ventricular fibrillation. "
07/01/1986 - "The conclusions of the present review strongly support those of the United States Food and Drug Administration, approving bretylium for prophylaxis and treatment of ventricular fibrillation."
07/01/1986 - "Deleterious effects of bretylium on hemodynamic recovery from ventricular fibrillation."

05/01/1981 - "In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy. "
05/01/2004 - "The quaternary amine, bretylium, is a class III antiarrhythmic drug used to treat ventricular tachycardia and fibrillation. "
08/01/1988 - "Clinical suppression of refractory ventricular tachycardia with oral bretylium not predicted by electrophysiologic drug testing."
02/01/1985 - "Pharmacologic responses to a placebo infusion and 3 separate bretylium infusions (2.5, 5.0, 10 mg/kg over 60 minutes) were assessed in 6 patients with recurrent, nonsustained ventricular tachycardia. "
06/01/1983 - "In one patient, ventricular tachycardia could not be induced after intravenous bretylium."

01/01/1988 - "The bretylium-treated animals also exhibited an improved renal pathology index but they did not differ from the controls with respect to proteinuria and hematuria. "
12/01/1988 - "In MRL/1 bretylium and both ACE inhibitors improved renal histopathology, but only captopril prolonged survival, and it decreased proteinuria and haematuria. "

11/01/2009 - "In contrast, studies suggest that immediate adequate intravenous bretylium administration therapy together with sustained effective chest compressions can induce chemical defibrillation or facilitate electrical defibrillation as well as reduce the intensity, or even need for potentially heart-damaging countershock, where early frequent excessive current shocks are likely to increase refractory arrhythmia as demonstrated in animals and in humans. "
07/01/1992 - "During cooling, the ventricular arrhythmia threshold (VAT) in control animals decreased from 10.1 +/- 1.9 to 4.4 +/- 1.3 impulses, while the VAT in bretylium-treated animals increased from 9.8 +/- 2.9 to 23.2 +/- 2.7 impulses. "
03/01/1989 - "In four dogs, bretylium (10 mg/kg) did not alter the time course of electrogram changes nor the time to onset of arrhythmia. "
01/01/1985 - "Bretylium is thus likely to continue to find increasing usage in the acute management of malignant ventricular arrhythmia."
09/01/1975 - "Bretylium pretreatment shortened the duration of the ventricular arrhythmia. "

02/01/2003 - "Bretylium in the treatment of complex regional pain syndrome: uncommon side-effect of a common drug."
06/01/1992 - "Patients with reflex sympathetic dystrophy, who received transient pain relief from stellate ganglion blocks or lumbar sympathetic blocks and had abnormal isolated cold stress tests, were enrolled in a study to determine the efficacy of intravenous regional bretylium. "
02/01/2002 - "Localized abdominal pain following sympathetic blockade with bretylium for the management of complex regional pain syndrome."
06/01/1992 - "Bretylium and lidocaine provided more than 30% pain relief for a mean of 20.0 (+/- 17.5) days, whereas lidocaine alone provided relief for only 2.7 (+/- 3.7) days (Mann-Whitney U-test, P less than 0.001). "
05/01/2007 - "Controlled trials have demonstrated that a short course of oral corticosteroids, intranasal or intramuscular calcitonin, intravenous bisphosphonates, free-radical scavengers, gabapentin, regional intravenous sympathetic blocks with bretylium and spinal cord stimulation or physical therapy and occupational therapy can be efficacious for complex regional pain syndrome. "