Effect of captopril on murine systemic lupus erythematosus disease.

Abstract

The MRL/1 and New Zealand black-New Zealand white cross (NZB x W) mice spontaneously develop a disease similar to systemic lupus erythematosus in man. The effect of antihypertensive treatment on MRL/1 and NZB x W mice was studied with respect to survival, blood pressure, proteinuria, haematuria and renal histopathology. The treatment consisted of angiotensin converting enzyme (ACE) inhibitors (captopril and enalapril) and bretylium, a sympathetic blocker. Tail systolic blood pressure was measured with a strain gauge technique. All antihypertensive drugs caused a reduction in blood pressure in both strains. In MRL/1 bretylium and both ACE inhibitors improved renal histopathology, but only captopril prolonged survival, and it decreased proteinuria and haematuria. In NZB x W captopril decreased proteinuria but did not influence survival or renal histopathology. Bretylium was without any effect on these parameters. At the doses used captopril improves survival in MRL/1 mice and decreases proteinuria and haematuria in both MRL/1 and NZB x W mice. Since bretylium and enalapril lack this property despite a similar blood pressure reduction, it seems to be a drug-specific action.

• Authors: H Herlitz, C Svalander, A Tarkowski, G Westberg
• Journal: Journal of hypertension. Supplement : official journal of the International Society of Hypertension (J Hypertens Suppl) Vol. 6 Issue 4 Pg. S684-6 (Dec 1988) ISSN: 0952-1178 [Print] England
• PMID: 2853767 (Publication Type: Journal Article)

Chemical References

• Bretylium Compounds
• Enalapril
• Captopril
• bretylium

Topics

• Animals
• Blood Pressure
• Bretylium Compounds (pharmacology)
• Captopril (pharmacology)
• Enalapril (pharmacology)
• Hypertension (drug therapy)
• Lupus Erythematosus, Systemic (complications, drug therapy)
• Mice
• Mice, Mutant Strains