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ASP3662

a novel 11beta-hydroxysteroid dehydrogenase 1 inhibitor

Also Known As:

4-(5-(2-(4-chloro-2,6-difluorophenoxy)propan-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorobenzamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kakimoto, Shuichiro: 1 article (10/2018)
2.	Kiso, Tetsuo: 1 article (10/2018)
3.	Sekizawa, Toshihiro: 1 article (10/2018)
4.	Tsukamoto, Mina: 1 article (10/2018)
5.	Uchino, Hiroshi: 1 article (10/2018)

Related Diseases

1.	Myalgia 10/01/2018 - "ASP3662 also restored muscle pressure thresholds in reserpine-induced myalgia rats. "
2.	Pain (Aches) 10/01/2018 - "Here, we examined the effects of ASP3662, a novel 11β-HSD1 inhibitor, on neuropathic and dysfunctional pain. " 10/01/2018 - "The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia." 10/01/2018 - "Analgesic effects of ASP3662, a novel 11β-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain." 10/01/2018 - "The enzyme inhibitory activities and pharmacokinetics of ASP3662 were examined, and its antinociceptive effects were evaluated in models of neuropathic pain, fibromyalgia and inflammatory pain in Sprague-Dawley rats. "
3.	Neuralgia (Stump Neuralgia) 10/01/2018 - "The enzyme inhibitory activities and pharmacokinetics of ASP3662 were examined, and its antinociceptive effects were evaluated in models of neuropathic pain, fibromyalgia and inflammatory pain in Sprague-Dawley rats. "
4.	Hyperalgesia 10/01/2018 - "Single oral administration of ASP3662 ameliorated mechanical allodynia in spinal nerve ligation (SNL) and streptozotocin-induced diabetic rats and thermal hyperalgesia in chronic constriction nerve injury rats. "
5.	Fibromyalgia (Fibrositis) 10/01/2018 - "The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia." 10/01/2018 - "The enzyme inhibitory activities and pharmacokinetics of ASP3662 were examined, and its antinociceptive effects were evaluated in models of neuropathic pain, fibromyalgia and inflammatory pain in Sprague-Dawley rats. "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Reserpine (Serpasil)
3.	Oxidoreductases (Dehydrogenase)
4.	Enzymes
5.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Ligation
2.	Oral Administration