Triazoles

08/01/2003 - "Triazoles are safe and effective for treating most invasive fungal infections. "
08/01/2009 - "Efficacy of triazoles in a murine disseminated infection by Candida krusei."
08/01/2009 - "The efficacy of prophylactic broad-spectrum triazoles against invasive mould infections in HSCT recipients has now been demonstrated in two large prospective studies. "
10/01/2013 - "Triazoles are currently the drugs of choice for the treatment of Trichosporon infections. "
04/02/2013 - "Overall, the PT-gp120 model provides a starting point for both the rational design of higher-affinity peptide triazoles and the development of structure-minimized entry inhibitors that can trap gp120 into an inactive conformation and prevent infection."

11/01/2010 - "For candidaemia and invasive candidiasis amphotericin B or an echinocandin are recommended as first-line treatment, with extended-spectrum triazoles acceptable alternatives. "
12/01/2008 - "Recent clinical trials have documented the clinical efficacy of the echinocandins and the newer triazoles for the management of invasive candidiasis. "
12/01/2012 - "Outcome of pediatric invasive candidiasis was similar in response to polyenes (73%), triazoles (67%) and echinocandins (73%). "
10/01/2011 - "Triazoles, polyenes, and echinocandins are the key drugs used to treat invasive candidiasis in ICU patients with similar efficacy, but very variable tolerability. "
01/01/2006 - "The current role of second-generation triazoles and echinocandins is for treatment of invasive candidiasis and invasive aspergillosis in patients who are critically ill and immunocompromised. "

05/01/1989 - "Current investigation is focused on the triazoles, which may offer improved therapy for cryptococcosis. "
08/01/1995 - "Prophylaxis with triazoles can prevent cryptococcosis and may be considered for adults and adolescents with CD4+ counts of < 50/microL. "
07/01/2009 - "In 1999, heteroresistance to triazoles was reported in Cryptococcus neoformans strains isolated from an azole therapy failure case of cryptococcosis in an AIDS patient and in a diagnostic strain from a non-AIDS patient. "
08/01/1995 - "Although most authorities favor an initial period of therapy with amphotericin B for acute cryptococcosis, the triazoles play a role in both the management of acute disease and subsequent maintenance therapy. "
07/01/1991 - "The efficacy of two triazoles, SCH 39304 and fluconazole, in the treatment of disseminated cryptococcosis in Wistar rats was determined. "

01/01/2015 - "The mainstay of therapy of Aspergillus diseases is triazoles but several studies globally highlighted variable prevalence of triazole resistance, which hampers the management of aspergillosis. "
01/01/2014 - "fumigatus, detection of resistance to antifugal triazoles, and epidemiological studies for establishing the necessary measures for prevention and control of aspergillosis. "
11/01/2013 - "Triazoles are first-line agents for treating aspergillosis. "
01/01/2013 - "Recent reports on emergence of resistance to triazoles among Aspergillus spp. is a cause of concern for treatment of patients with invasive aspergillosis. "
12/01/2010 - "Currently, newer triazoles are recommended as initial therapy for invasive aspergillosis in immunodeficiency states such as CGD."

02/01/1990 - "It remains to be determined what place these new triazoles have in managing immunosuppressed patients including those with acquired immune deficiency syndrome known as AIDS. "
07/01/2009 - "In 1999, heteroresistance to triazoles was reported in Cryptococcus neoformans strains isolated from an azole therapy failure case of cryptococcosis in an AIDS patient and in a diagnostic strain from a non-AIDS patient. "
08/01/1998 - "neoformans isolates from the UK have remained unchanged despite the recent widespread use of triazoles for long-term maintenance of patients with AIDS-associated cryptococcal meningitis. "
07/01/2009 - "neoformans isolated from clinical and environmental sources before 1979, prior to the advent of triazoles, and 16 fluconazole (FLC)-resistant strains isolated from AIDS patients undergoing FLC maintenance therapy during 1990 to 2000. "
06/01/2006 - "Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole."