Reserpine (Serpasil)

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

Also Known As:

Networked: 2013 relevant articles (67 outcomes, 157 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Silva, Regina H: 8 articles (07/2015 - 05/2002)
2.	Abílio, Vanessa C: 7 articles (09/2013 - 05/2002)
3.	Singh, Amanpreet: 6 articles (02/2006 - 06/2003)
4.	Naidu, Pattipati S: 6 articles (02/2006 - 06/2003)
5.	Kulkarni, Shrinivas K: 6 articles (02/2006 - 06/2003)
6.	Frussa-Filho, Roberto: 6 articles (06/2005 - 05/2002)
7.	Fachinetto, Roselei: 5 articles (10/2013 - 12/2004)
8.	Rocha, João B T: 5 articles (04/2009 - 02/2003)
9.	Ribeiro, Alessandra M: 4 articles (07/2015 - 08/2008)
10.	Reckziegel, Patrícia: 4 articles (10/2013 - 04/2009)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2009 - "Blood pressure lowering efficacy of reserpine for primary hypertension." 09/01/1997 - "Low-dose reserpine/thiazide combination in first-line treatment of hypertension: efficacy and safety compared to an ACE inhibitor." 02/01/1997 - "Thus, the use of this low-dose reserpine-thiazide combination appears to be a rational alternative to conventional monotherapy in the first-line treatment of hypertension." 10/01/1967 - "[On the efficacy of reserpine in hypertension of the lesser circulation]." 01/01/2009 - "Included studies were truly randomised controlled trials comparing reserpine monotherapy to placebo or no treatment in patients with primary hypertension. "
2.	Movement Disorders (Movement Disorder) 01/01/2012 - "The present study concludes that the oxidative stress might play an important role in reserpine-induced abnormal oral movements, and Murraya koenigii may have great potential in the treatment of neuroleptic-induced orofacial dyskinesia. " 01/01/2012 - "In this study, the neuroprotective potential and in vivo antioxidant status of extract of roots and rhizomes of Rubia cordifolia L (MERC) in reserpine-induced orofacial dyskinesia was studied. " 04/01/2011 - "In the present study, reserpine (1 mg kg(-1), s.c.) was given to rats on days 1, 3 and 5 to induce orofacial dyskinesia, which is characterised by increased vacuous chewing and tongue protrusion. " 07/01/2009 - "The results of the present study suggested that Hibiscus rosa sinensis had a protective role against reserpine-induced orofacial dyskinesia and oxidative stress." 05/14/2002 - "The aim of the present study was to investigate the effects of reserpine administration on the development of orofacial dyskinesia and on plus-maze discriminative avoidance task (DAT-an animal model of associative learning) in male and female mice. "
3.	Parkinson Disease (Parkinson's Disease) 07/01/2007 - "Furthermore, we apply the method to study the changes of endogenous peptide levels in mouse brain striatum after administration of reserpine, a classical model drug for inducing Parkinson disease symptoms." 07/01/2015 - "The administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson's disease (PD). " 07/01/2015 - "Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson's Disease: New Perspectives to a Long-Standing Model." 08/21/2013 - "In contrast, reserpine (20 and 40 mg/L) did not evoke overt acute behavioral effects, but markedly reduced activity 7 days later, resembling motor retardation observed in depression and/or Parkinson's disease. " 05/16/2012 - "Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease."
4.	Pain (Aches) 06/01/2014 - "Our study provides strong evidence that Gent inhibits reserpine-induced pain/depression dyad by downregulating GluN2B receptors in the amygdala." 03/01/2015 - "Pain may be further amplified by reserpine-induced dysfunction of the descending pain inhibitory system and by the decrease in peripheral drive to this system resulting from a reduced proportion of mechanoresponsive C-nociceptors." 03/01/2015 - "Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model." 06/01/2014 - "Systemic Gent administration dose-dependently ameliorated the behavioral deficits associated with reserpine-induced pain/depression dyad. " 06/01/2014 - "However, the effects of Gent on the reserpine-induced pain/depression dyad and its underlying mechanisms are unclear. "
5.	Ulcer 06/01/1968 - "Studies on the experimental gastrointestinal ulcers produced by reserpine and stress. " 03/01/1968 - "Studies on the experimental gastrointestinal ulcers produced by reserpine and stress. " 12/01/1967 - "Studies on the experimental gastrointestinal ulcers produced by reserpine and stress. " 07/01/1997 - "Marked antiulcerative properties of a Populus tremula bark extract were demonstrated in experiments on mice and rats with stress-, reserpine-induced, and acetylsalicylic ulcers. " 09/01/1993 - "The authors' data provide evidence that reserpine is not associated with ulcer disease in elderly persons and suggest that a history of ulcer disease need not be a contraindication to the use of this drug."

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Chlorpromazine (Thorazine)
3.	Dopamine (Intropin)
4.	Levodopa (L Dopa)
5.	Haloperidol (Haldol)
6.	Reserpine (Serpasil)
7.	Hydralazine (Apresoline)
8.	Hydrochlorothiazide (Esidrix)
9.	Adrenocorticotropic Hormone (ACTH)
10.	Norepinephrine (Noradrenaline)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Adrenalectomy
3.	Intravenous Injections
4.	Intramuscular Injections
5.	Vagus Nerve Stimulation