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MC2625

a histone deacetylase inhibitor with antineoplastic activity; structure in first source

Also Known As:

3-(5-(2,3-diphenylpropanamido)pyridin-2-yl)-N-hydroxyacrylamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - MC2625: 2
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - MC2625: 2
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - MC2625: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - MC2625: 2

Experts

1.	Mai, Antonello: 2 articles (01/2016 - 05/2015)
2.	Valente, Sergio: 2 articles (01/2016 - 05/2015)
3.	Zwergel, Clemens: 2 articles (01/2016 - 05/2015)
4.	Artico, Marco: 1 article (01/2016)
5.	Bertalot, Thomas: 1 article (01/2016)
6.	Conconi, Maria Teresa: 1 article (01/2016)
7.	Di Liddo, Rosa: 1 article (01/2016)
8.	Marrocco, Biagina: 1 article (01/2016)
9.	Scarpa, Carlotta: 1 article (01/2016)
10.	Schrenk, Sandra: 1 article (01/2016)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 05/14/2015 - "When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. "
2.	Ewing Sarcoma (Sarcoma, Ewing) 05/14/2015 - "When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. "
3.	Rhabdomyosarcoma 05/14/2015 - "When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. "
4.	Inflammation (Inflammations) 05/01/2016 - "These results underline the potential application of MC2625 and MC2780 in inflammation-related diseases." 05/01/2016 - "Herein, using KB31, C2C12, and 3T3-J2 cell lines, we demonstrated that, under lipopolysaccharide-induced in vitro inflammation, HDAC3/6/8 inhibitor MC2625 and HDAC6-selective inhibitor MC2780 were effective at a concentration of 30 ng/mL to downregulate mRNA expression of pro-inflammatory cytokines (IL-1β and IL-6) and to promote the transcription of IL-10 gene, without affecting the cell viability. "

Related Drugs and Biologics

1.	Interleukin-10 (Interleukin 10)
2.	Cytokines
3.	Tubulin
4.	Messenger RNA (mRNA)
5.	Lipopolysaccharides
6.	MC1742